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Items: 1 to 20 of 39

1.

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity.

Uttam S, Wong C, Price TJ, Khoutorsky A.

Front Genet. 2018 Oct 24;9:470. doi: 10.3389/fgene.2018.00470. eCollection 2018. Review.

2.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ.

J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.

PMID:
30459229
3.

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.

Gantois I, Popic J, Khoutorsky A, Sonenberg N.

Annu Rev Med. 2018 Oct 26. doi: 10.1146/annurev-med-081117-041238. [Epub ahead of print]

PMID:
30365357
4.

Translation deregulation in human disease.

Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):791-807. doi: 10.1038/s41580-018-0034-x. Review.

PMID:
30038383
5.

eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons.

Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ.

Front Cell Neurosci. 2018 Feb 6;12:29. doi: 10.3389/fncel.2018.00029. eCollection 2018.

6.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

7.

Translational Control Mechanisms in Persistent Pain.

Khoutorsky A, Price TJ.

Trends Neurosci. 2018 Feb;41(2):100-114. doi: 10.1016/j.tins.2017.11.006. Review.

8.

Epiregulin and EGFR interactions are involved in pain processing.

Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L.

J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7.

9.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ.

J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3.

10.

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N.

Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15.

PMID:
28504725
11.

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, Chan CM, Pooters T, Groves I, Martin LJ, Sonenberg N, Gkogkas CG, Mogil JS.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5515-5520. doi: 10.1073/pnas.1703477114. Epub 2017 May 8.

12.

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. Epub 2016 Oct 24.

13.

eIF2α phosphorylation controls thermal nociception.

Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. Epub 2016 Oct 3.

14.

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.

Skalecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J.

Dev Neurobiol. 2016 Dec;76(12):1308-1327. doi: 10.1002/dneu.22392. Epub 2016 Apr 7.

15.

Translational control of nociception via 4E-binding protein 1.

Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N.

Elife. 2015 Dec 18;4. pii: e12002. doi: 10.7554/eLife.12002.

16.

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.

Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N.

J Neurosci. 2015 Aug 5;35(31):11125-32. doi: 10.1523/JNEUROSCI.4615-14.2015.

17.

mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.

Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE.

Mol Cancer Res. 2015 Oct;13(10):1377-88. doi: 10.1158/1541-7786.MCR-15-0184-T. Epub 2015 Jun 30.

18.

Translational control of chronic pain.

Melemedjian OK, Khoutorsky A.

Prog Mol Biol Transl Sci. 2015;131:185-213. doi: 10.1016/bs.pmbts.2014.11.006. Epub 2015 Jan 30. Review.

PMID:
25744674
19.

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.

Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N.

Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26.

20.

Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1.

Prager-Khoutorsky M, Khoutorsky A, Bourque CW.

Neuron. 2014 Aug 20;83(4):866-78. doi: 10.1016/j.neuron.2014.07.023. Epub 2014 Aug 7.

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