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Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.

Thompson AC, Bruss MD, Price JC, Khambatta CF, Holmes WE, Colangelo M, Dalidd M, Roberts LS, Astle CM, Harrison DE, Hellerstein MK.

Aging Cell. 2016 Feb;15(1):118-27. doi: 10.1111/acel.12414. Epub 2015 Nov 6.


The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics.

Price JC, Khambatta CF, Li KW, Bruss MD, Shankaran M, Dalidd M, Floreani NA, Roberts LS, Turner SM, Holmes WE, Hellerstein MK.

Mol Cell Proteomics. 2012 Dec;11(12):1801-14. doi: 10.1074/mcp.M112.021204. Epub 2012 Sep 13.


The effects of physiological adaptations to calorie restriction on global cell proliferation rates.

Bruss MD, Thompson AC, Aggarwal I, Khambatta CF, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E735-45. doi: 10.1152/ajpendo.00661.2010. Epub 2011 Feb 1.


Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates.

Bruss MD, Khambatta CF, Ruby MA, Aggarwal I, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E108-16. doi: 10.1152/ajpendo.00524.2009. Epub 2009 Nov 3.

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