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Items: 1 to 20 of 86


Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.

Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS.

Neuron. 2018 Sep 19;99(6):1170-1187.e9. doi: 10.1016/j.neuron.2018.08.015. Epub 2018 Aug 30.


Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.

Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, Lauritzen M.

Brain. 2018 Jul 1;141(7):2032-2046. doi: 10.1093/brain/awy143.


Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain.

Octeau JC, Faas G, Mody I, Khakh BS.

J Vis Exp. 2018 May 7;(135). doi: 10.3791/57511.


An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

Octeau JC, Chai H, Jiang R, Bonanno SL, Martin KC, Khakh BS.

Neuron. 2018 Apr 4;98(1):49-66.e9. doi: 10.1016/j.neuron.2018.03.003.


Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.

Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG.

Cell Rep. 2017 Oct 10;21(2):517-532. doi: 10.1016/j.celrep.2017.09.047.


Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS.

Neuron. 2017 Aug 2;95(3):531-549.e9. doi: 10.1016/j.neuron.2017.06.029. Epub 2017 Jul 14.


Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.

Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R.

Trends Neurosci. 2017 Jul;40(7):422-437. doi: 10.1016/j.tins.2017.05.002. Epub 2017 May 31. Review.


New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.

Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS.

Neuron. 2016 Dec 21;92(6):1181-1195. doi: 10.1016/j.neuron.2016.11.030. Epub 2016 Dec 8.


P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.

Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS.

J Neurosci. 2016 Aug 24;36(34):8902-20. doi: 10.1523/JNEUROSCI.1496-16.2016.


Astrocyte scar formation aids central nervous system axon regeneration.

Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV.

Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30.


Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.

Jiang R, Diaz-Castro B, Looger LL, Khakh BS.

J Neurosci. 2016 Mar 23;36(12):3453-70. doi: 10.1523/JNEUROSCI.3693-15.2016.


Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.


Probing the Complexities of Astrocyte Calcium Signaling.

Shigetomi E, Patel S, Khakh BS.

Trends Cell Biol. 2016 Apr;26(4):300-312. doi: 10.1016/j.tcb.2016.01.003. Epub 2016 Feb 16. Review.


New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling.

Olsen ML, Khakh BS, Skatchkov SN, Zhou M, Lee CJ, Rouach N.

J Neurosci. 2015 Oct 14;35(41):13827-35. doi: 10.1523/JNEUROSCI.2603-15.2015. Review.


Diversity of astrocyte functions and phenotypes in neural circuits.

Khakh BS, Sofroniew MV.

Nat Neurosci. 2015 Jul;18(7):942-52. doi: 10.1038/nn.4043. Review.


Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.

Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS.

Nat Neurosci. 2015 May;18(5):708-17. doi: 10.1038/nn.4001. Epub 2015 Apr 20.


Astrocyte calcium signaling: from observations to functions and the challenges therein.

Khakh BS, McCarthy KD.

Cold Spring Harb Perspect Biol. 2015 Jan 20;7(4):a020404. doi: 10.1101/cshperspect.a020404. Review.


Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators.

Jiang R, Haustein MD, Sofroniew MV, Khakh BS.

J Vis Exp. 2014 Nov 19;(93):e51972. doi: 10.3791/51972.


ATP-gated P2X receptors in health and disease.

Burnstock G, Nistri A, Khakh BS, Giniatullin R.

Front Cell Neurosci. 2014 Jul 24;8:204. doi: 10.3389/fncel.2014.00204. eCollection 2014. No abstract available.


Slow neuromodulation mediated by ATP P2X receptors.

Xu J, Khakh BS.

Neuron. 2014 Jul 16;83(2):257-259. doi: 10.1016/j.neuron.2014.06.028.

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