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Items: 1 to 20 of 46


Ouabain increases neuronal branching in hippocampus and improves spatial memory.

Orellana AM, Leite JA, Kinoshita PF, Vasconcelos AR, Andreotti DZ, de Sá Lima L, Xavier GF, Kawamoto EM, Scavone C.

Neuropharmacology. 2018 Sep 15;140:260-274. doi: 10.1016/j.neuropharm.2018.08.008. Epub 2018 Aug 9.


Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.

Cabral-Costa JV, Andreotti DZ, Mello NP, Scavone C, Camandola S, Kawamoto EM.

Sci Rep. 2018 Jun 5;8(1):8595. doi: 10.1038/s41598-018-26814-6.


Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.

Mazucanti CH, Kawamoto EM, Mattson MP, Scavone C, Camandola S.

J Cereb Blood Flow Metab. 2018 Mar 1:271678X18762700. doi: 10.1177/0271678X18762700. [Epub ahead of print]


Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

Kinoshita PF, Yshii LM, Orellana AMM, Paixão AG, Vasconcelos AR, Lima LS, Kawamoto EM, Scavone C.

Sci Rep. 2017 Jul 7;7(1):4894. doi: 10.1038/s41598-017-05075-9.


The relevance of α-KLOTHO to the central nervous system: Some key questions.

Cararo-Lopes MM, Mazucanti CHY, Scavone C, Kawamoto EM, Berwick DC.

Ageing Res Rev. 2017 Jul;36:137-148. doi: 10.1016/j.arr.2017.03.003. Epub 2017 Mar 18. Review.


The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence.

Kinoshita PF, Leite JA, Orellana AM, Vasconcelos AR, Quintas LE, Kawamoto EM, Scavone C.

Front Physiol. 2016 Jun 2;7:195. doi: 10.3389/fphys.2016.00195. eCollection 2016. Review.


Cardiotonic Steroids as Modulators of Neuroinflammation.

Orellana AM, Kinoshita PF, Leite JA, Kawamoto EM, Scavone C.

Front Endocrinol (Lausanne). 2016 Feb 16;7:10. doi: 10.3389/fendo.2016.00010. eCollection 2016. Review.


The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions.

Vasconcelos AR, Cabral-Costa JV, Mazucanti CH, Scavone C, Kawamoto EM.

Front Endocrinol (Lausanne). 2016 Feb 4;7:9. doi: 10.3389/fendo.2016.00009. eCollection 2016. Review.


Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus.

Orellana AM, Vasconcelos AR, Leite JA, de Sá Lima L, Andreotti DZ, Munhoz CD, Kawamoto EM, Scavone C.

Aging (Albany NY). 2015 Dec;7(12):1094-111.


Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration.

Mazucanti CH, Cabral-Costa JV, Vasconcelos AR, Andreotti DZ, Scavone C, Kawamoto EM.

Curr Top Med Chem. 2015;15(21):2116-38. Review.


Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats.

Degaspari S, Tzanno-Martins CB, Fujihara CK, Zatz R, Branco-Martins JP, Viel TA, Buck Hde S, Orellana AM, Böhmer AE, Lima Lde S, Andreotti DZ, Munhoz CD, Scavone C, Kawamoto EM.

PLoS One. 2015 May 11;10(5):e0125271. doi: 10.1371/journal.pone.0125271. eCollection 2015.


Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus.

Vasconcelos AR, Kinoshita PF, Yshii LM, Marques Orellana AM, Böhmer AE, de Sá Lima L, Alves R, Andreotti DZ, Marcourakis T, Scavone C, Kawamoto EM.

Neurobiol Aging. 2015 May;36(5):1914-23. doi: 10.1016/j.neurobiolaging.2015.02.020. Epub 2015 Feb 28.


Signaling function of Na,K-ATPase induced by ouabain against LPS as an inflammation model in hippocampus.

Kinoshita PF, Yshii LM, Vasconcelos AR, Orellana AM, Lima Lde S, Davel AP, Rossoni LV, Kawamoto EM, Scavone C.

J Neuroinflammation. 2014 Dec 31;11:218. doi: 10.1186/s12974-014-0218-z.


Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.

Vasconcelos AR, Yshii LM, Viel TA, Buck HS, Mattson MP, Scavone C, Kawamoto EM.

J Neuroinflammation. 2014 May 6;11:85. doi: 10.1186/1742-2094-11-85.


TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes.

Kawamoto EM, Cutler RG, Rothman SM, Mattson MP, Camandola S.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):731-7. doi: 10.1016/j.bbrc.2013.12.039. Epub 2013 Dec 14.


Sonic hedgehog promotes autophagy in hippocampal neurons.

Petralia RS, Schwartz CM, Wang YX, Kawamoto EM, Mattson MP, Yao PJ.

Biol Open. 2013 Apr 8;2(5):499-504. doi: 10.1242/bio.20134275. Print 2013 May 15.


Ouabain activates NFκB through an NMDA signaling pathway in cultured cerebellar cells.

de Sá Lima L, Kawamoto EM, Munhoz CD, Kinoshita PF, Orellana AM, Curi R, Rossoni LV, Avellar MC, Scavone C.

Neuropharmacology. 2013 Oct;73:327-36. doi: 10.1016/j.neuropharm.2013.06.006. Epub 2013 Jun 15.


Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes.

Hutchison ER, Kawamoto EM, Taub DD, Lal A, Abdelmohsen K, Zhang Y, Wood WH 3rd, Lehrmann E, Camandola S, Becker KG, Gorospe M, Mattson MP.

Glia. 2013 Jul;61(7):1018-28. doi: 10.1002/glia.22483. Epub 2013 May 7.


Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway.

Son TG, Kawamoto EM, Yu QS, Greig NH, Mattson MP, Camandola S.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):602-6. doi: 10.1016/j.bbrc.2013.03.041. Epub 2013 Mar 26.


Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.

Liu D, Pitta M, Jiang H, Lee JH, Zhang G, Chen X, Kawamoto EM, Mattson MP.

Neurobiol Aging. 2013 Jun;34(6):1564-80. doi: 10.1016/j.neurobiolaging.2012.11.020. Epub 2012 Dec 25. Erratum in: Neurobiol Aging. 2013 Sep;34(9):e3.

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