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To the editor in reply to Dr. Crow's letter.

Mustelin T, Ukadike K, LaCava J, Taylor MS.

Arthritis Rheumatol. 2019 Sep 12. doi: 10.1002/art.41104. [Epub ahead of print]


High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements (LINE-1) in systemic lupus erythematosus.

Carter V, LaCava J, Taylor MS, Liang SY, Mustelin C, Ukadike KC, Bengtsson A, Lood C, Mustelin T.

Arthritis Rheumatol. 2019 Jul 24. doi: 10.1002/art.41054. [Epub ahead of print]


Identification of RNase-sensitive LINE-1 Ribonucleoprotein Interactions by Differential Affinity Immobilization.

Jiang H, Taylor MS, Molloy KR, Altukhov I, LaCava J.

Bio Protoc. 2019 Apr 5;9(7). pii: e3200. doi: 10.21769/BioProtoc.3200.


RNA Binding Proteins as Regulators of Retrotransposon-Induced Exonization.

LaCava J.

Bioessays. 2019 Feb;41(2):e1800263. doi: 10.1002/bies.201800263. Epub 2019 Feb 8. No abstract available.


Targeting the CALR interactome in myeloproliferative neoplasms.

Pronier E, Cifani P, Merlinsky TR, Berman KB, Somasundara AVH, Rampal RK, LaCava J, Wei KE, Pastore F, Maag JL, Park J, Koche R, Kentsis A, Levine RL.

JCI Insight. 2018 Nov 15;3(22). pii: 122703. doi: 10.1172/jci.insight.122703.


Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms.

Chan HL, Beckedorff F, Zhang Y, Garcia-Huidobro J, Jiang H, Colaprico A, Bilbao D, Figueroa ME, LaCava J, Shiekhattar R, Morey L.

Nat Commun. 2018 Aug 23;9(1):3377. doi: 10.1038/s41467-018-05728-x.


Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2.

Zinoviev A, Goyal A, Jindal S, LaCava J, Komar AA, Rodnina MV, Hellen CUT, Pestova TV.

Genes Dev. 2018 Sep 1;32(17-18):1226-1241. doi: 10.1101/gad.314724.118. Epub 2018 Aug 14.


LINE-1 protein localization and functional dynamics during the cell cycle.

Mita P, Wudzinska A, Sun X, Andrade J, Nayak S, Kahler DJ, Badri S, LaCava J, Ueberheide B, Yun CY, Fenyö D, Boeke JD.

Elife. 2018 Jan 8;7. pii: e30058. doi: 10.7554/eLife.30058.


Dissection of affinity captured LINE-1 macromolecular complexes.

Taylor MS, Altukhov I, Molloy KR, Mita P, Jiang H, Adney EM, Wudzinska A, Badri S, Ischenko D, Eng G, Burns KH, Fenyö D, Chait BT, Alexeev D, Rout MP, Boeke JD, LaCava J.

Elife. 2018 Jan 8;7. pii: e30094. doi: 10.7554/eLife.30094.


Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

Winczura K, Schmid M, Iasillo C, Molloy KR, Harder LM, Andersen JS, LaCava J, Jensen TH.

Cell Rep. 2018 Jan 2;22(1):44-58. doi: 10.1016/j.celrep.2017.12.037.


Tumor suppressor NPRL2 induces ROS production and DNA damage response.

Ma Y, Silveri L, LaCava J, Dokudovskaya S.

Sci Rep. 2017 Nov 10;7(1):15311. doi: 10.1038/s41598-017-15497-0.


The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity.

Santanach A, Blanco E, Jiang H, Molloy KR, Sansó M, LaCava J, Morey L, Di Croce L.

Nat Commun. 2017 Nov 1;8(1):1235. doi: 10.1038/s41467-017-01464-w.


Affinity Purification of the RNA Degradation Complex, the Exosome, from HEK-293 Cells.

Domanski M, LaCava J.

Bio Protoc. 2017 Apr 20;7(8). pii: e2238. doi: 10.21769/BioProtoc.2238.


RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells.

Domanski M, LaCava J.

Bio Protoc. 2017 Apr 20;7(8). pii: e2239. doi: 10.21769/BioProtoc.2239.


Protein Complex Affinity Capture from Cryomilled Mammalian Cells.

LaCava J, Jiang H, Rout MP.

J Vis Exp. 2016 Dec 9;(118). doi: 10.3791/54518.


Purification and analysis of endogenous human RNA exosome complexes.

Domanski M, Upla P, Rice WJ, Molloy KR, Ketaren NE, Stokes DL, Jensen TH, Rout MP, LaCava J.

RNA. 2016 Sep;22(9):1467-75. doi: 10.1261/rna.057760.116. Epub 2016 Jul 11.


Protein Complex Purification by Affinity Capture.

LaCava J, Fernandez-Martinez J, Hakhverdyan Z, Rout MP.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.top077545.


Density Gradient Ultracentrifugation to Isolate Endogenous Protein Complexes after Affinity Capture.

Fernandez-Martinez J, LaCava J, Rout MP.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087957.


Native Elution of Yeast Protein Complexes Obtained by Affinity Capture.

LaCava J, Fernandez-Martinez J, Rout MP.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087940.


Optimized Affinity Capture of Yeast Protein Complexes.

LaCava J, Fernandez-Martinez J, Hakhverdyan Z, Rout MP.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087932.


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