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Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention.

Norris BA, Ernst JD.

PLoS Pathog. 2018 Oct 26;14(10):e1007154. doi: 10.1371/journal.ppat.1007154. eCollection 2018 Oct.


Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design.

Ernst JD.

Cell Host Microbe. 2018 Jul 11;24(1):34-42. doi: 10.1016/j.chom.2018.06.004. Review.


Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation.

Ernst JD, Cornelius A, Desvignes L, Tavs J, Norris BA.

J Infect Dis. 2018 Oct 5;218(10):1653-1662. doi: 10.1093/infdis/jiy142.


A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.

Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL; TBRU-ASTRa Study Group.

J Immunol. 2018 Apr 15;200(8):3008-3019. doi: 10.4049/jimmunol.1701737. Epub 2018 Mar 14.


Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis.

Ernst JD.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):706-707. doi: 10.1164/rccm.201712-2368ED. No abstract available.


Antigenic Variation and Immune Escape in the MTBC.

Ernst JD.

Adv Exp Med Biol. 2017;1019:171-190. doi: 10.1007/978-3-319-64371-7_9. Review.


Fishing for Answers in Human Mycobacterial Infections.

Bolz M, Ernst JD.

Immunity. 2017 Sep 19;47(3):395-397. doi: 10.1016/j.immuni.2017.09.005.


"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.

Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H.

Vaccine. 2017 Jun 14;35(27):3433-3440. doi: 10.1016/j.vaccine.2017.04.007. Epub 2017 May 2.


Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.

Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst JD; TBRU-ASTRa Study Team.

Hum Immunol. 2017 Apr;78(4):325-326. doi: 10.1016/j.humimm.2017.03.007. Epub 2017 Mar 16.


Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity.

Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst JD.

PLoS Pathog. 2016 Dec 14;12(12):e1006111. doi: 10.1371/journal.ppat.1006111. eCollection 2016 Dec.


Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.

Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR Jr, Philips JA.

Nat Microbiol. 2016 Dec 5;2:16232. doi: 10.1038/nmicrobiol.2016.232.


Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection.

Wiens KE, Ernst JD.

J Infect Dis. 2016 Dec 15;214(12):1893-1896. Epub 2016 Oct 31.


The Challenge of Latent TB Infection.

Blumberg HM, Ernst JD.

JAMA. 2016 Sep 6;316(9):931-3. doi: 10.1001/jama.2016.11021. No abstract available.


The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.

Wiens KE, Ernst JD.

PLoS Pathog. 2016 Aug 8;12(8):e1005809. doi: 10.1371/journal.ppat.1005809. eCollection 2016 Aug.


A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A.

PLoS Pathog. 2016 Jul 13;12(7):e1005760. doi: 10.1371/journal.ppat.1005760. eCollection 2016 Jul.


Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.

Srivastava S, Grace PS, Ernst JD.

Cell Host Microbe. 2016 Jan 13;19(1):44-54. doi: 10.1016/j.chom.2015.12.003.


Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N.

PLoS Pathog. 2015 Dec 9;11(12):e1005336. doi: 10.1371/journal.ppat.1005336. eCollection 2015 Dec.


M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.

Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S.

Cell Host Microbe. 2015 Nov 11;18(5):538-48.


Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.

Grace PS, Ernst JD.

J Immunol. 2016 Jan 1;196(1):357-64. doi: 10.4049/jimmunol.1501494. Epub 2015 Nov 16.


Impaired M. tuberculosis Antigen-Specific IFN-╬│ Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis.

Fan L, Xiao H, Mai G, Su B, Ernst J, Hu Z.

PLoS One. 2015 May 27;10(5):e0127087. doi: 10.1371/journal.pone.0127087. eCollection 2015.

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