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Items: 12

1.

Liquid chromatography-mass spectrometry as a general approach for investigating covalent binding of drugs to DNA.

Raja M, Albertí J, Saurina J, Sentellas S.

Anal Bioanal Chem. 2016 May;408(14):3911-22. doi: 10.1007/s00216-016-9481-4. Epub 2016 Mar 23.

PMID:
27007736
2.

The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.

Gavaldà A, Ramos I, Carcasona C, Calama E, Otal R, Montero JL, Sentellas S, Aparici M, Vilella D, Alberti J, Beleta J, Miralpeix M.

Pulm Pharmacol Ther. 2014 Aug;28(2):114-21. doi: 10.1016/j.pupt.2014.05.005. Epub 2014 Jun 10.

3.

GSSG/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress.

Sentellas S, Morales-Ibanez O, Zanuy M, Albertí JJ.

Toxicol In Vitro. 2014 Aug;28(5):1006-15. doi: 10.1016/j.tiv.2014.04.017. Epub 2014 May 6.

PMID:
24809893
4.

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS.

Losada C, Albertí JJ, Saurina J, Sentellas S.

Anal Bioanal Chem. 2012 Aug;404(2):539-51. doi: 10.1007/s00216-012-6145-x. Epub 2012 Jun 23.

PMID:
22722741
5.

Characterization of in vitro metabolic profiles of cinitapride obtained with liver microsomes of humans and various mammal species using UHPLC and chemometric methods for data analysis.

Marquez H, Albertí J, Salvà M, Saurina J, Sentellas S.

Anal Bioanal Chem. 2012 May;403(4):909-16. doi: 10.1007/s00216-012-5795-z. Epub 2012 Feb 24.

PMID:
22362276
6.

Development of a UHPLC method for the assessment of the metabolic profile of cinitapride.

Marquez H, Albertí J, Salvà M, Saurina J, Sentellas S.

J Sep Sci. 2011 Dec;34(24):3502-8. doi: 10.1002/jssc.201100073. Epub 2011 Jun 22.

PMID:
21695682
7.

Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist.

Eastwood P, Esteve C, González J, Fonquerna S, Aiguadé J, Carranco I, Doménech T, Aparici M, Miralpeix M, Albertí J, Córdoba M, Fernández R, Pont M, Godessart N, Prats N, Loza MI, Cadavid MI, Nueda A, Vidal B.

ACS Med Chem Lett. 2010 Dec 20;2(3):213-8. doi: 10.1021/ml100249e. eCollection 2011 Mar 10.

8.

In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism.

Albertí JJ, Sentellas S, Salvà M.

Biochem Pharmacol. 2011 Mar 15;81(6):761-76. doi: 10.1016/j.bcp.2010.12.013. Epub 2010 Dec 22.

PMID:
21184745
9.

Identification of the human enzymes responsible for the enzymatic hydrolysis of aclidinium bromide.

Albertí J, Martinet A, Sentellas S, Salvà M.

Drug Metab Dispos. 2010 Jul;38(7):1202-10. doi: 10.1124/dmd.109.031724. Epub 2010 Mar 23.

10.

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.

Eastwood P, Gonzalez J, Paredes S, Nueda A, Domenech T, Alberti J, Vidal B.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. doi: 10.1016/j.bmcl.2010.01.045. Epub 2010 Jan 20.

PMID:
20137946
11.

Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.

Sentellas S, Ramos I, Albertí J, Salvà M, Antón F, Miralpeix M, Beleta J, Gavaldà A.

Eur J Pharm Sci. 2010 Mar 18;39(5):283-90. doi: 10.1016/j.ejps.2010.01.004. Epub 2010 Jan 20. Review.

PMID:
20093184
12.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).

Prat M, Fernández D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monleón JM, Gavaldà A, Miralpeix M, Ramos I, Doménech T, Vilella D, Antón F, Huerta JM, Espinosa S, López M, Sentellas S, González M, Albertí J, Segarra V, Cárdenas A, Beleta J, Ryder H.

J Med Chem. 2009 Aug 27;52(16):5076-92. doi: 10.1021/jm900132z.

PMID:
19653626

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