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Items: 1 to 20 of 32

1.

C9orf72-dependent lysosomal functions regulate epigenetic control of autophagy and lipid metabolism.

Liu Y, Wang J.

Autophagy. 2019 Feb 15. doi: 10.1080/15548627.2019.1580106. [Epub ahead of print]

PMID:
30767689
2.

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

Alexander EJ, Ghanbari Niaki A, Zhang T, Sarkar J, Liu Y, Nirujogi RS, Pandey A, Myong S, Wang J.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11485-E11494. doi: 10.1073/pnas.1811997115. Epub 2018 Nov 15.

PMID:
30442662
3.

A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.

Liu Y, Wang T, Ji YJ, Johnson K, Liu H, Johnson K, Bailey S, Suk Y, Lu YN, Liu M, Wang J.

Genes Dev. 2018 Nov 1;32(21-22):1380-1397. doi: 10.1101/gad.315564.118. Epub 2018 Oct 26.

PMID:
30366907
4.

Autophagy as a common pathway in amyotrophic lateral sclerosis.

Nguyen DKH, Thombre R, Wang J.

Neurosci Lett. 2018 Apr 4. pii: S0304-3940(18)30261-1. doi: 10.1016/j.neulet.2018.04.006. [Epub ahead of print] Review.

PMID:
29626651
5.

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J.

Mol Cell. 2018 Mar 1;69(5):787-801.e8. doi: 10.1016/j.molcel.2018.02.001.

PMID:
29499134
6.

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.

Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, Van Den Bosch L, Robberecht W.

Acta Neuropathol. 2018 Mar;135(3):427-443. doi: 10.1007/s00401-017-1796-5. Epub 2018 Jan 4.

PMID:
29302778
7.

Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog.

Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP.

Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.

8.

Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus.

Zhong Y, Wang J, Henderson MJ, Yang P, Hagen BM, Siddique T, Vogel BE, Deng HX, Fang S.

Elife. 2017 May 2;6. pii: e23759. doi: 10.7554/eLife.23759.

9.

Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72.

Ji YJ, Ugolino J, Brady NR, Hamacher-Brady A, Wang J.

Autophagy. 2017 Jul 3;13(7):1254-1255. doi: 10.1080/15548627.2017.1299312.

10.

Effect of mutation mechanisms on variant composition and distribution in Caenorhabditis elegans.

Hwang HY, Wang J.

PLoS Comput Biol. 2017 Jan 30;13(1):e1005369. doi: 10.1371/journal.pcbi.1005369. eCollection 2017 Jan.

11.

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.

Ugolino J, Ji YJ, Conchina K, Chu J, Nirujogi RS, Pandey A, Brady NR, Hamacher-Brady A, Wang J.

PLoS Genet. 2016 Nov 22;12(11):e1006443. doi: 10.1371/journal.pgen.1006443. eCollection 2016 Nov.

12.

Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG.

J Neurosci. 2015 Oct 21;35(42):14286-306. doi: 10.1523/JNEUROSCI.0642-15.2015.

13.

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD.

Nature. 2015 Sep 3;525(7567):56-61. doi: 10.1038/nature14973. Epub 2015 Aug 26.

14.

Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.

Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J.

PLoS Biol. 2015 Apr 2;13(4):e1002114. doi: 10.1371/journal.pbio.1002114. eCollection 2015 Apr.

15.

Emerging role of RNA‚ÄĘDNA hybrids in C9orf72-linked neurodegeneration.

Wang J, Haeusler AR, Simko EA.

Cell Cycle. 2015;14(4):526-32. doi: 10.1080/15384101.2014.995490. Review.

16.

RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.

Zhang T, Baldie G, Periz G, Wang J.

PLoS Genet. 2014 Oct 16;10(10):e1004693. doi: 10.1371/journal.pgen.1004693. eCollection 2014 Oct.

17.

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J.

Nature. 2014 Mar 13;507(7491):195-200. doi: 10.1038/nature13124. Epub 2014 Mar 5.

18.

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD.

Neuron. 2013 Oct 16;80(2):415-28. doi: 10.1016/j.neuron.2013.10.015. Erratum in: Neuron. 2013 Nov 20;80(4):1102. Heusler, Aaron R [corrected to Haeusler, Aaron R].

19.

Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.

Zhang T, Hwang HY, Hao H, Talbot C Jr, Wang J.

J Biol Chem. 2012 Mar 9;287(11):8371-82. doi: 10.1074/jbc.M111.311977. Epub 2012 Jan 9.

20.

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling.

Zhang T, Mullane PC, Periz G, Wang J.

Hum Mol Genet. 2011 May 15;20(10):1952-65. doi: 10.1093/hmg/ddr076. Epub 2011 Feb 25.

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