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Items: 1 to 20 of 69


Netrin Synergizes Signaling and Adhesion through DCC.

Meijers R, Smock RG, Zhang Y, Wang JH.

Trends Biochem Sci. 2019 Nov 5. pii: S0968-0004(19)30206-3. doi: 10.1016/j.tibs.2019.10.005. [Epub ahead of print] Review.


Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state.

Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22556-22566. doi: 10.1073/pnas.1912427116. Epub 2019 Oct 17.


NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology.

Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL.

J Biomol NMR. 2019 Jul;73(6-7):319-332. doi: 10.1007/s10858-019-00234-8. Epub 2019 Feb 27.


Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.

Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R.

Neuron. 2018 Mar 21;97(6):1261-1267.e4. doi: 10.1016/j.neuron.2018.02.010. Epub 2018 Mar 1.


The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.

Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH.

Cell Discov. 2018 Feb 20;4:8. doi: 10.1038/s41421-017-0008-8. eCollection 2018.


Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC.

Finci LI, Zhang J, Sun X, Smock RG, Meijers R, Zhang Y, Xiao J, Wang JH.

Protein Cell. 2017 Sep;8(9):701-705. doi: 10.1007/s13238-017-0439-x. No abstract available.


Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.

Li X, Lamothe PA, Walker BD, Wang JH.

Cell Mol Immunol. 2017 Jul;14(7):631-634. doi: 10.1038/cmi.2017.24. Epub 2017 May 29. No abstract available.


Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2.

Xu S, Wang J, Wang JH, Springer TA.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3403-3408. doi: 10.1073/pnas.1620881114. Epub 2017 Mar 14.


Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.

Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH.

Protein Cell. 2016 Oct;7(10):761-765. No abstract available.


Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition.

Li SA, Cheng L, Yu Y, Wang JH, Chen Q.

Sci Adv. 2016 May 27;2(5):e1501118. doi: 10.1126/sciadv.1501118. eCollection 2016 May.


Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination.

Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL.

Front Immunol. 2015 Sep 3;6:441. doi: 10.3389/fimmu.2015.00441. eCollection 2015. Review.


Transmembrane signaling: A multiplex problem with converging solutions.

Chou JJ, Wang JH.

Prog Biophys Mol Biol. 2015 Sep;118(3):87-8. doi: 10.1016/j.pbiomolbio.2015.06.006. Epub 2015 Jul 2. No abstract available.


Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1.

Cheng L, Li SA, Wang JH, Yu Y, Chen Q.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):775-8. doi: 10.1107/S2053230X15008201. Epub 2015 May 22. Erratum in: Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72 (Pt 12):911.


Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.

Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8373-8. doi: 10.1073/pnas.1504971112. Epub 2015 Jun 8.


Codification of bidentate pMHC interaction with TCR and its co-receptor.

Reinherz EL, Wang JH.

Trends Immunol. 2015 May;36(5):300-6. doi: 10.1016/ Epub 2015 Mar 26. Review.


Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. doi: 10.1073/pnas.1424829112. Epub 2015 Jan 20.


Terazosin activates Pgk1 and Hsp90 to promote stress resistance.

Chen X, Zhao C, Li X, Wang T, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L.

Nat Chem Biol. 2015 Jan;11(1):19-25. doi: 10.1038/nchembio.1657. Epub 2014 Nov 10.


Crystal structure of human Ankyrin G death domain.

Liu Y, Zhang Y, Wang JH.

Proteins. 2014 Dec;82(12):3476-82. doi: 10.1002/prot.24702. Epub 2014 Oct 21.


Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.

Gelfand MV, Hagan N, Tata A, Oh WJ, Lacoste B, Kang KT, Kopycinska J, Bischoff J, Wang JH, Gu C.

Elife. 2014 Sep 22;3:e03720. doi: 10.7554/eLife.03720.

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