Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 219

1.

Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA.

Finlay DB, Manning JJ, Ibsen MS, Macdonald CE, Patel M, Javitch JA, Banister SD, Glass M.

ACS Chem Neurosci. 2019 Sep 12. doi: 10.1021/acschemneuro.9b00429. [Epub ahead of print]

PMID:
31513380
2.

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR.

ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5.

PMID:
31339684
3.

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.

LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15947-15956. doi: 10.1073/pnas.1903020116. Epub 2019 Jul 19.

4.

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.

Donthamsetti PC, Broichhagen J, Vyklicky V, Stanley C, Fu Z, Visel M, Levitz JL, Javitch JA, Trauner D, Isacoff EY.

J Am Chem Soc. 2019 Jul 24;141(29):11522-11530. doi: 10.1021/jacs.9b02895. Epub 2019 Jul 10.

PMID:
31291105
5.

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.

Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D.

ACS Cent Sci. 2019 Jun 26;5(6):992-1001. doi: 10.1021/acscentsci.9b00141. Epub 2019 May 29.

6.

Come Fly with Me: An overview of dopamine receptors in Drosophila melanogaster.

Karam CS, Jones SK, Javitch JA.

Basic Clin Pharmacol Toxicol. 2019 Jun 20. doi: 10.1111/bcpt.13277. [Epub ahead of print] Review.

PMID:
31219669
7.

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence.

Ibsen MS, Finlay DB, Patel M, Javitch JA, Glass M, Grimsey NL.

Front Pharmacol. 2019 Apr 10;10:350. doi: 10.3389/fphar.2019.00350. eCollection 2019.

8.

The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface.

Schrader JM, Irving CM, Octeau JC, Christian JA, Aballo TJ, Kareemo DJ, Conti J, Camberg JL, Lane JR, Javitch JA, Kovoor A.

J Biol Chem. 2019 Apr 5;294(14):5604-5615. doi: 10.1074/jbc.RA118.004682. Epub 2019 Jan 22.

PMID:
30670597
9.

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion.

Farino ZJ, Morgenstern TJ, Maffei A, Quick M, De Solis AJ, Wiriyasermkul P, Freyberg RJ, Aslanoglou D, Sorisio D, Inbar BP, Free RB, Donthamsetti P, Mosharov EV, Kellendonk C, Schwartz GJ, Sibley DR, Schmauss C, Zeltser LM, Moore H, Harris PE, Javitch JA, Freyberg Z.

Mol Psychiatry. 2019 Jan 9. doi: 10.1038/s41380-018-0344-6. [Epub ahead of print]

10.

Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'.

Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ.

Nat Commun. 2018 Sep 3;9(1):3568. doi: 10.1038/s41467-018-05678-4. No abstract available.

11.

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.

Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0212-4. [Epub ahead of print]

12.

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi: 10.1073/pnas.1717444115. Epub 2018 Aug 6.

13.

Luciferase complementation based-detection of G-protein-coupled receptor activity.

Yano H, Cai NS, Javitch JA, Ferré S.

Biotechniques. 2018 Jul;65(1):9-14. doi: 10.2144/btn-2018-0039.

14.

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

Abramyan AM, Quick M, Xue C, Javitch JA, Shi L.

J Chem Inf Model. 2018 Jun 25;58(6):1244-1252. doi: 10.1021/acs.jcim.8b00175. Epub 2018 Jun 11.

15.

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP.

Neuron. 2018 May 2;98(3):575-587.e4. doi: 10.1016/j.neuron.2018.03.038. Epub 2018 Apr 12.

16.

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum.

Gallo EF, Meszaros J, Sherman JD, Chohan MO, Teboul E, Choi CS, Moore H, Javitch JA, Kellendonk C.

Nat Commun. 2018 Mar 14;9(1):1086. doi: 10.1038/s41467-018-03272-2.

17.

Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action.

Karam CS, Javitch JA.

Adv Pharmacol. 2018;82:205-234. doi: 10.1016/bs.apha.2017.09.002. Epub 2017 Oct 25. Review.

18.

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S.

Nat Commun. 2018 Feb 5;9(1):486. doi: 10.1038/s41467-017-02606-w.

19.

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.

Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.

Sci Rep. 2018 Jan 19;8(1):1208. doi: 10.1038/s41598-018-19642-1.

20.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L.

PLoS Comput Biol. 2018 Jan 16;14(1):e1005948. doi: 10.1371/journal.pcbi.1005948. eCollection 2018 Jan.

Supplemental Content

Loading ...
Support Center