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Brain Sci. 2018 Aug 9;8(8). pii: E149. doi: 10.3390/brainsci8080149.

Individualized Immunological Data for Precise Classification of OCD Patients.

Lamothe H1,2,3, Baleyte JM4,5, Smith P6, Pelissolo A7,8,9, Mallet L10,11,12,13.

Author information

1
Centre Hospitalier Intercommunal de Créteil, 94000 Créteil, France. lamothehugues@gmail.com.
2
Institut du Cerveau et de la Moelle Epinière, Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, 75013 Paris, France. lamothehugues@gmail.com.
3
Fondation FondaMental, 94000 Créteil, France. lamothehugues@gmail.com.
4
Centre Hospitalier Intercommunal de Créteil, 94000 Créteil, France. jean-marc.baleyte@chicreteil.fr.
5
Fondation FondaMental, 94000 Créteil, France. jean-marc.baleyte@chicreteil.fr.
6
Institut du Cerveau et de la Moelle Epinière, Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, 75013 Paris, France. pauline.hh.smith@gmail.com.
7
Fondation FondaMental, 94000 Créteil, France. a.pelissolo@gmail.com.
8
Assistance Publique-Hôpitaux de Paris, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Université Paris-Est Créteil, 94000 Créteil, France. a.pelissolo@gmail.com.
9
INSERM, U955, Team 15, 94000 Créteil, France. a.pelissolo@gmail.com.
10
Institut du Cerveau et de la Moelle Epinière, Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, 75013 Paris, France. luc.mallet@inserm.fr.
11
Fondation FondaMental, 94000 Créteil, France. luc.mallet@inserm.fr.
12
Assistance Publique-Hôpitaux de Paris, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Université Paris-Est Créteil, 94000 Créteil, France. luc.mallet@inserm.fr.
13
Department of Mental Health and Psychiatry, Global Health Institute, University of Geneva, 1202 Geneva, Switzerland. luc.mallet@inserm.fr.

Abstract

Obsessive⁻compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

KEYWORDS:

OCD; Streptococcus pyogenes; Tourette syndrome; Toxoplasma gondii; cytokines; immunology; obsessive–compulsive disorder; pediatric acute-onset neuropsychiatric syndrome (PANS); pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS); psychiatry

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