Send to

Choose Destination

See 1 citation found by title matching your search:

J Clin Endocrinol Metab. 2017 May 9. doi: 10.1210/jc.2017-00342. [Epub ahead of print]

Impact of Vitamin D deficiency on subclinical carotid atherosclerosis: a pooled analysis of cohort studies.

Author information

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
Centro Cardiologico Monzino, IRCCS, Milan, Italy
Department of Advanced Biomedical Sciences, Division of Cardiology, Federico II University, Naples, Italy



Vitamin D deficiency patients have an increased cardiovascular (CV) morbidity and mortality. Carotid intima-media thickness (IMT) and carotid plaques are markers of subclinical atherosclerosis and predictors of CV events.


To perform a meta-analysis of studies evaluating the impact of Vitamin D deficiency on common carotid artery IMT (CCA-IMT) and on the prevalence of carotid plaques.

Data Sources:

Studies were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases.


Twenty-one studies (3,777 Vitamin D deficiency patients and 4,792 controls) with data on CCA-IMT and 6 studies (1,889 Vitamin D deficiency patients and 2,883 controls) on the prevalence of carotid plaques were included. Compared to controls, Vitamin D deficiency patients showed a significantly higher CCA-IMT (mean difference [MD]: 0.043 mm; 95%CI: 0.030, 0.056; P<0.001), and an increased prevalence of carotid plaques (Odds Ratio [OR]: 2.29, 95%CI: 1.03-5.11; P=0.043) with an attributable risk of 35.9%. When selecting studies specifically including patients with diabetes, the prevalence of carotid plaques in Vitamin D deficiency patients than in controls resulted higher (OR: 3.27; 95%CI: 1,62-6.62; P=0.001). A significant difference in CCA-IMT was confirmed when comparing patients with Vitamin D insufficiency to controls (MD: 0.011; 95%CI: 0.010-0.012, P<0.001). Sensitivity analyses substantially confirmed results and regression models showed that with the exception of LDL-cholesterol, HDL-cholesterol, triglycerides and the prevalence of hypercholesterolemia, all the other clinical and demographic co-variates significantly impacted on the difference in CCA-IMT between Vitamin D deficiency patients and controls.


Both Vitamin D deficiency and Vitamin D insufficiency are associated with subclinical atherosclerosis, potentially suggesting an increased CV risk in these clinical settings.


atherosclerosis; ldl cholesterol lipoproteins; high density lipoprotein cholesterol; triglycerides; hypercholesterolemia; diabetes mellitus; vitamin d deficiency; cardiovascular disease risk factors; carotid atherosclerosis; diabetes mellitus, type 2; cardiovascular system; carotid artery, common; demography; morbidity; mortality; cardiovascular event; attributable; sensitivity analysis; carotid intima-media thickness; embase


Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center