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Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks.

Rizzolo K, Houry WA.

J Biol Chem. 2018 Sep 7. pii: jbc.TM118.002805. doi: 10.1074/jbc.TM118.002805. [Epub ahead of print]


Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.

Wong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao YQ, Rizzolo K, Leung E, Moutaoufik MT, Hoell L, Phanse S, Goodreid J, Barbosa LRS, Ramos CHI, Babu M, Mennella V, Batey RA, Schimmer AD, Houry WA.

Cell Chem Biol. 2018 Aug 16;25(8):1017-1030.e9. doi: 10.1016/j.chembiol.2018.05.014. Epub 2018 Jun 28.


Reversible inhibition of the ClpP protease via an N-terminal conformational switch.

Vahidi S, Ripstein ZA, Bonomi M, Yuwen T, Mabanglo MF, Juravsky JB, Rizzolo K, Velyvis A, Houry WA, Vendruscolo M, Rubinstein JL, Kay LE.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6447-E6456. doi: 10.1073/pnas.1805125115. Epub 2018 Jun 25.


The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases.

Bhandari V, Wong KS, Zhou JL, Mabanglo MF, Batey RA, Houry WA.

ACS Chem Biol. 2018 Jun 15;13(6):1413-1425. doi: 10.1021/acschembio.8b00124. Epub 2018 Jun 1.


Systems analysis of the genetic interaction network of yeast molecular chaperones.

Rizzolo K, Kumar A, Kakihara Y, Phanse S, Minic Z, Snider J, Stagljar I, Zilles S, Babu M, Houry WA.

Mol Omics. 2018 Apr 16;14(2):82-94. doi: 10.1039/C7MO00142H.


The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Houry WA, Bertrand E, Coulombe B.

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5.


Computational Analysis of the Chaperone Interaction Networks.

Kumar A, Rizzolo K, Zilles S, Babu M, Houry WA.

Methods Mol Biol. 2018;1709:275-291. doi: 10.1007/978-1-4939-7477-1_20.


Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA.

Cell Rep. 2017 Sep 12;20(11):2735-2748. doi: 10.1016/j.celrep.2017.08.074.


The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology.

Mao YQ, Houry WA.

Front Mol Biosci. 2017 Aug 24;4:58. doi: 10.3389/fmolb.2017.00058. eCollection 2017. Review.


The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex.

Wong KS, Bhandari V, Janga SC, Houry WA.

J Mol Biol. 2017 Jan 20;429(2):324-344. doi: 10.1016/j.jmb.2016.12.008. Epub 2016 Dec 12.


Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.

Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pom├Ęs R, Sharpe S, Houry WA.

Structure. 2016 Jul 6;24(7):1095-109. doi: 10.1016/j.str.2016.05.002. Epub 2016 Jun 2.


Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.

Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR.

Structure. 2016 May 3;24(5):657-666. doi: 10.1016/j.str.2016.03.018. Epub 2016 Apr 21.


Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.

Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I.

Sci Rep. 2016 Apr 15;6:24601. doi: 10.1038/srep24601.


Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.

Goodreid JD, Janetzko J, Santa Maria JP Jr, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA.

J Med Chem. 2016 Jan 28;59(2):624-46. doi: 10.1021/acs.jmedchem.5b01451. Epub 2016 Jan 12.


Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL.

Bhandari V, Houry WA.

Adv Exp Med Biol. 2015;883:271-94. doi: 10.1007/978-3-319-23603-2_15. Review.


Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD.

Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004.


The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.

Matias PM, Baek SH, Bandeiras TM, Dutta A, Houry WA, Llorca O, Rosenbaum J.

Front Mol Biosci. 2015 May 5;2:17. doi: 10.3389/fmolb.2015.00017. eCollection 2015.


Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency.

Jeganathan A, Leong V, Zhao L, Huen J, Nano N, Houry WA, Ortega J.

J Mol Biol. 2015 May 22;427(10):1875-86. doi: 10.1016/j.jmb.2015.01.010. Epub 2015 Jan 28.


Novel function discovery with GeneMANIA: a new integrated resource for gene function prediction in Escherichia coli.

Vlasblom J, Zuberi K, Rodriguez H, Arnold R, Gagarinova A, Deineko V, Kumar A, Leung E, Rizzolo K, Samanfar B, Chang L, Phanse S, Golshani A, Greenblatt JF, Houry WA, Emili A, Morris Q, Bader G, Babu M.

Bioinformatics. 2015 Feb 1;31(3):306-10. doi: 10.1093/bioinformatics/btu671. Epub 2014 Oct 13.


Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

Goodreid JD, Wong K, Leung E, McCaw SE, Gray-Owen SD, Lough A, Houry WA, Batey RA.

J Nat Prod. 2014 Oct 24;77(10):2170-81. doi: 10.1021/np500158q. Epub 2014 Sep 25.


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