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Items: 1 to 20 of 93

1.

Chemical Modulation of Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.

Wong KS, Houry WA.

ACS Chem Biol. 2019 Jul 10. doi: 10.1021/acschembio.9b00347. [Epub ahead of print]

PMID:
31241890
2.

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M.

Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2.

PMID:
31056398
3.

Strategies for purification of the bacteriophage HK97 small and large terminase subunits that yield pure and homogeneous samples that are functional.

Weiditch SA, Seraphim TV, Houry WA, Kanelis V.

Protein Expr Purif. 2019 Aug;160:45-55. doi: 10.1016/j.pep.2019.03.017. Epub 2019 Apr 4.

PMID:
30954531
4.

The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex.

Lynham J, Houry WA.

Adv Exp Med Biol. 2018;1106:37-72. doi: 10.1007/978-3-030-00737-9_4. Review.

PMID:
30484152
5.

Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation.

Shorter J, Houry WA.

Front Mol Biosci. 2018 Oct 2;5:85. doi: 10.3389/fmolb.2018.00085. eCollection 2018. No abstract available.

6.

Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks.

Rizzolo K, Houry WA.

J Biol Chem. 2019 Feb 8;294(6):2142-2150. doi: 10.1074/jbc.TM118.002805. Epub 2018 Sep 7. Review.

7.

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.

Wong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao YQ, Rizzolo K, Leung E, Moutaoufik MT, Hoell L, Phanse S, Goodreid J, Barbosa LRS, Ramos CHI, Babu M, Mennella V, Batey RA, Schimmer AD, Houry WA.

Cell Chem Biol. 2018 Aug 16;25(8):1017-1030.e9. doi: 10.1016/j.chembiol.2018.05.014. Epub 2018 Jun 28.

PMID:
30126533
8.

Reversible inhibition of the ClpP protease via an N-terminal conformational switch.

Vahidi S, Ripstein ZA, Bonomi M, Yuwen T, Mabanglo MF, Juravsky JB, Rizzolo K, Velyvis A, Houry WA, Vendruscolo M, Rubinstein JL, Kay LE.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6447-E6456. doi: 10.1073/pnas.1805125115. Epub 2018 Jun 25.

9.

The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases.

Bhandari V, Wong KS, Zhou JL, Mabanglo MF, Batey RA, Houry WA.

ACS Chem Biol. 2018 Jun 15;13(6):1413-1425. doi: 10.1021/acschembio.8b00124. Epub 2018 Jun 1. Review.

PMID:
29775273
10.

Systems analysis of the genetic interaction network of yeast molecular chaperones.

Rizzolo K, Kumar A, Kakihara Y, Phanse S, Minic Z, Snider J, Stagljar I, Zilles S, Babu M, Houry WA.

Mol Omics. 2018 Apr 16;14(2):82-94. doi: 10.1039/C7MO00142H.

PMID:
29659649
11.

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Houry WA, Bertrand E, Coulombe B.

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5. Review.

PMID:
29203338
12.

Computational Analysis of the Chaperone Interaction Networks.

Kumar A, Rizzolo K, Zilles S, Babu M, Houry WA.

Methods Mol Biol. 2018;1709:275-291. doi: 10.1007/978-1-4939-7477-1_20.

PMID:
29177666
13.

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA.

Cell Rep. 2017 Sep 12;20(11):2735-2748. doi: 10.1016/j.celrep.2017.08.074.

14.

The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology.

Mao YQ, Houry WA.

Front Mol Biosci. 2017 Aug 24;4:58. doi: 10.3389/fmolb.2017.00058. eCollection 2017. Review.

15.

The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex.

Wong KS, Bhandari V, Janga SC, Houry WA.

J Mol Biol. 2017 Jan 20;429(2):324-344. doi: 10.1016/j.jmb.2016.12.008. Epub 2016 Dec 12.

16.

Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.

Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pom├Ęs R, Sharpe S, Houry WA.

Structure. 2016 Jul 6;24(7):1095-109. doi: 10.1016/j.str.2016.05.002. Epub 2016 Jun 2.

17.

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.

Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR.

Structure. 2016 May 3;24(5):657-666. doi: 10.1016/j.str.2016.03.018. Epub 2016 Apr 21.

18.

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.

Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I.

Sci Rep. 2016 Apr 15;6:24601. doi: 10.1038/srep24601.

19.

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.

Goodreid JD, Janetzko J, Santa Maria JP Jr, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA.

J Med Chem. 2016 Jan 28;59(2):624-46. doi: 10.1021/acs.jmedchem.5b01451. Epub 2016 Jan 12.

PMID:
26818454
20.

Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL.

Bhandari V, Houry WA.

Adv Exp Med Biol. 2015;883:271-94. doi: 10.1007/978-3-319-23603-2_15. Review.

PMID:
26621473

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