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Items: 1 to 20 of 194

1.

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M.

Diabetes. 2018 Aug;67(8):1589-1603. doi: 10.2337/db17-1089. Epub 2018 Jun 5.

PMID:
29871859
2.

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.

Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5.

3.

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity.

Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS.

Elife. 2017 Dec 15;6. pii: e29968. doi: 10.7554/eLife.29968.

4.

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS.

Cell. 2017 Nov 16;171(5):1094-1109.e15. doi: 10.1016/j.cell.2017.10.003.

PMID:
29149604
5.

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384b.

PMID:
29117173
6.

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS.

Cell Rep. 2017 Oct 10;21(2):393-402. doi: 10.1016/j.celrep.2017.09.051.

7.

Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

Hotamisligil GS.

Immunity. 2017 Sep 19;47(3):406-420. doi: 10.1016/j.immuni.2017.08.009. Review.

8.

ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity.

Garfinkel BP, Hotamisligil GS.

Mol Cell. 2017 Jun 15;66(6):731-733. doi: 10.1016/j.molcel.2017.05.037.

9.

Type I Interferons Interfere with Liver Glucose Metabolism.

Parlakgul G, Hotamisligil GS.

Cell Metab. 2017 Jun 6;25(6):1211-1212. doi: 10.1016/j.cmet.2017.05.009.

10.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

11.

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS.

Nature. 2017 Mar 9;543(7644):252-256. doi: 10.1038/nature21379. Epub 2017 Feb 20.

12.

Inflammation, metaflammation and immunometabolic disorders.

Hotamisligil GS.

Nature. 2017 Feb 8;542(7640):177-185. doi: 10.1038/nature21363. Review.

PMID:
28179656
13.

Immune Cell Intolerance for Excess Cholesterol.

Widenmaier SB, Hotamışlıgil GS.

Immunity. 2016 Dec 20;45(6):1186-1188. doi: 10.1016/j.immuni.2016.12.006.

14.

Cell Signaling and Stress Responses.

Hotamisligil GS, Davis RJ.

Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10). pii: a006072. doi: 10.1101/cshperspect.a006072. Review.

15.

Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation.

Çimen I, Kocatürk B, Koyuncu S, Tufanlı Ö, Onat UI, Yıldırım AD, Apaydın O, Demirsoy Ş, Aykut ZG, Nguyen UT, Watkins SM, Hotamışlıgil GS, Erbay E.

Sci Transl Med. 2016 Sep 28;8(358):358ra126. doi: 10.1126/scitranslmed.aaf9087.

PMID:
27683551
16.

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.

Ertunc ME, Hotamisligil GS.

J Lipid Res. 2016 Dec;57(12):2099-2114. Epub 2016 Jun 21. Review.

17.

De Novo Lipogenesis Products and Endogenous Lipokines.

Yilmaz M, Claiborn KC, Hotamisligil GS.

Diabetes. 2016 Jul;65(7):1800-7. doi: 10.2337/db16-0251. Epub 2016 Jun 10. Review.

18.

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1122-31. doi: 10.1161/ATVBAHA.116.307580. Epub 2016 Apr 21.

19.

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L.

Cell Rep. 2016 Jan 26;14(3):422-428. doi: 10.1016/j.celrep.2015.12.042. Epub 2016 Jan 7.

20.

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS.

Sci Transl Med. 2015 Dec 23;7(319):319ra205. doi: 10.1126/scitranslmed.aac6336. Epub 2015 Dec 23.

PMID:
26702093

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