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Items: 6

1.

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL.

Inflamm Res. 2019 Apr;68(4):261-274. doi: 10.1007/s00011-019-01218-y. Epub 2019 Feb 9.

PMID:
30739130
3.

A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma.

Kollmeier AP, Barnathan ES, O'Brien C, Chen B, Xia YK, Zhou B, Loza MJ, Silkoff PE, Ge M, Thurmond RL.

Ann Allergy Asthma Immunol. 2018 Nov;121(5):568-574. doi: 10.1016/j.anai.2018.08.001. Epub 2018 Aug 11.

PMID:
30102965
4.

An Immunohistochemical Investigation of Renal Phospholipidosis and Toxicity in Rats.

Ma JY, Snook S, Garrovillo S, Johnson C, La D.

Int J Toxicol. 2017 Sep/Oct;36(5):386-394. doi: 10.1177/1091581817726040. Epub 2017 Aug 18.

PMID:
28820006
5.

Clinical Development of Histamine H4 Receptor Antagonists.

Thurmond RL, Venable J, Savall B, La D, Snook S, Dunford PJ, Edwards JP.

Handb Exp Pharmacol. 2017;241:301-320. doi: 10.1007/164_2016_130. Review.

PMID:
28233185
6.

Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies.

Thurmond RL, Greenspan A, Radziszewski W, Xu XL, Miao Y, Chen B, Ge T, Zhou B, Baker DG, Pavlova D, Ritchlin CT, Tanaka Y, Takeuchi T, Smolen JS.

J Rheumatol. 2016 Sep;43(9):1637-42. doi: 10.3899/jrheum.160164. Epub 2016 Jul 15.

PMID:
27422891

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