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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1988 1
1990 1
1992 1
1993 1
1997 1
2000 2
2001 6
2002 8
2003 21
2004 22
2005 21
2006 32
2007 28
2008 45
2009 55
2010 65
2011 74
2012 75
2013 63
2014 73
2015 49
2016 63
2017 45
2018 56
2019 50
2020 42
2021 38
2022 24
2023 19
2024 11

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855 results

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Page 1
The histamine H4 receptor: from orphan to the clinic.
Thurmond RL. Thurmond RL. Front Pharmacol. 2015 Mar 31;6:65. doi: 10.3389/fphar.2015.00065. eCollection 2015. Front Pharmacol. 2015. PMID: 25873897 Free PMC article. Review.
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other hist …
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-pro …
Histamine H4 Receptor Antagonists: A New Approach for Tinnitus Treatment?
Hagenow J, Stark H. Hagenow J, et al. Recent Pat CNS Drug Discov. 2015;10(1):6-9. doi: 10.2174/1574889810666150424161907. Recent Pat CNS Drug Discov. 2015. PMID: 25909438 Review.
A patent from the small French start-up company Sensorion suggests the use of histamine H4 receptor (H4R) inhibitors as potential treatment. Since histamine and its receptor subtypes are strongly involved in neuronal and inflammatory processes i …
A patent from the small French start-up company Sensorion suggests the use of histamine H4 receptor (H4R) inhibitors as …
The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut.
Schirmer B, Neumann D. Schirmer B, et al. Int J Mol Sci. 2021 Jun 6;22(11):6116. doi: 10.3390/ijms22116116. Int J Mol Sci. 2021. PMID: 34204101 Free PMC article. Review.
Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H(1)R) antagonists, which are used to control allergic inflammation, antagonists at H(2)R, which …
Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds co …
Histamine H4 receptor: insights into a potential therapeutic target in breast cancer.
Martinel Lamas DJ, Rivera ES, Medina VA. Martinel Lamas DJ, et al. Front Biosci (Schol Ed). 2015 Jun 1;7(1):1-9. doi: 10.2741/S420. Front Biosci (Schol Ed). 2015. PMID: 25961682 Free article. Review.
Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involve …
Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the cri …
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
Tichenor MS, Thurmond RL, Venable JD, Savall BM. Tichenor MS, et al. J Med Chem. 2015 Sep 24;58(18):7119-27. doi: 10.1021/acs.jmedchem.5b00516. Epub 2015 Jun 3. J Med Chem. 2015. PMID: 25993395 Review.
The biological effects of histamine are mediated by four histamine receptors with distinct functions and distribution profiles (H1-H4). The most recently discovered histamine receptor (H4) has emerged as a promising drug target for …
The biological effects of histamine are mediated by four histamine receptors with distinct functions and distribution p …
The histamine H4 receptor: targeting inflammatory disorders.
Walter M, Kottke T, Stark H. Walter M, et al. Eur J Pharmacol. 2011 Oct 1;668(1-2):1-5. doi: 10.1016/j.ejphar.2011.06.029. Epub 2011 Jul 3. Eur J Pharmacol. 2011. PMID: 21741967 Review.
The discovery of the histamine H(4) receptor has added a new chapter to the century of extensive biogenic amine research. ...Selective H(4) receptor ligands and/or synergism of histamine H(1) and H(4) receptor modulation may be more effective in …
The discovery of the histamine H(4) receptor has added a new chapter to the century of extensive biogenic amine research. ...S …
Novel histamine H4 receptor ligands and their potential therapeutic applications: an update.
Kiss R, Keseru GM. Kiss R, et al. Expert Opin Ther Pat. 2014 Nov;24(11):1185-97. doi: 10.1517/13543776.2014.959494. Epub 2014 Sep 15. Expert Opin Ther Pat. 2014. PMID: 25219452 Review.
INTRODUCTION: Histamine H4 receptor (H4R) has been shown to be involved in various inflammatory conditions. ...For the first time, the positive proof-of-concept clinical trials of the H4 antagonist JNJ39758979 have demonstrated this potential in his …
INTRODUCTION: Histamine H4 receptor (H4R) has been shown to be involved in various inflammatory conditions. ...For the …
Histamine H4 receptor ligands: future applications and state of art.
Corrêa MF, dos Santos Fernandes JP. Corrêa MF, et al. Chem Biol Drug Des. 2015 Apr;85(4):461-80. doi: 10.1111/cbdd.12431. Epub 2014 Oct 27. Chem Biol Drug Des. 2015. PMID: 25228262 Review.
Histamine is a chemical transmitter found practically in whole organism and exerts its effects through the interaction with H1 to H4 histaminergic receptors. ...Therefore, H4 receptor ligands can have applications in the treatment of chronic inf …
Histamine is a chemical transmitter found practically in whole organism and exerts its effects through the interaction with H1 to …
Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.
Clauzure M, Táquez Delgado MA, Phillip JM, Revuelta MV, Cerchietti L, Medina VA. Clauzure M, et al. Int J Mol Sci. 2022 Jan 26;23(3):1378. doi: 10.3390/ijms23031378. Int J Mol Sci. 2022. PMID: 35163302 Free PMC article.
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. ...We conclude that the H4R is expr …
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine …
Histamine H4 receptor ligands and their potential therapeutic applications: an update.
Kiss R, Keserű GM. Kiss R, et al. Expert Opin Ther Pat. 2012 Mar;22(3):205-21. doi: 10.1517/13543776.2012.665447. Epub 2012 Mar 3. Expert Opin Ther Pat. 2012. PMID: 22385042 Review.
INTRODUCTION: Several studies underlined the critical role of histamine H4 receptor (H4R) in inflammation, thus H4 modulators have been suggested as promising drug candidates in inflammatory diseases. First H4 ligands typically have indole or am …
INTRODUCTION: Several studies underlined the critical role of histamine H4 receptor (H4R) in inflammation, thus H4 …
855 results