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Items: 1 to 20 of 31


Cis autocatalytic cleavage of glycine-linked Zika virus NS2B-NS3 protease constructs.

von Hammerstein F, Lauth LM, Hammerschmidt S, Wagner A, Schirmeister T, Hellmich UA.

FEBS Lett. 2019 Jun 26. doi: 10.1002/1873-3468.13507. [Epub ahead of print]


Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.

Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA.

Structure. 2019 Aug 6;27(8):1246-1257.e5. doi: 10.1016/j.str.2019.04.016. Epub 2019 Jun 6.


19F NMR as a versatile tool to study membrane protein structure and dynamics.

Rose-Sperling D, Tran MA, Lauth LM, Goretzki B, Hellmich UA.

Biol Chem. 2019 May 23. pii: /j/bchm.ahead-of-print/hsz-2018-0473/hsz-2018-0473.xml. doi: 10.1515/hsz-2018-0473. [Epub ahead of print] Review.


Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA.

Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644. doi: 10.1002/anie.201810470. Epub 2019 Jan 30.


Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2.

Goretzki B, Glogowski NA, Diehl E, Duchardt-Ferner E, Hacker C, Gaudet R, Hellmich UA.

Structure. 2018 Dec 4;26(12):1583-1593.e5. doi: 10.1016/j.str.2018.08.002. Epub 2018 Sep 20.


Where do we go from here? Membrane protein research beyond the structure-function horizon.

Hellmich UA, McIlwain B, Doshi R.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):801-803. doi: 10.1016/j.bbamem.2017.12.016. Epub 2017 Dec 24. No abstract available.


Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):927-942. doi: 10.1016/j.bbamem.2017.12.013. Epub 2017 Dec 16. Review.


Comparison of mechanistic transport cycle models of ABC exporters.

Szöllősi D, Rose-Sperling D, Hellmich UA, Stockner T.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):818-832. doi: 10.1016/j.bbamem.2017.10.028. Epub 2017 Oct 31. Review.


Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M.

J Med Chem. 2017 Aug 24;60(16):6911-6923. doi: 10.1021/acs.jmedchem.7b00405. Epub 2017 Aug 11.


Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form.

Wagner A, Diehl E, Krauth-Siegel RL, Hellmich UA.

Biomol NMR Assign. 2017 Oct;11(2):193-196. doi: 10.1007/s12104-017-9746-7. Epub 2017 Jun 1.


Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.

Latorre A, Schirmeister T, Kesselring J, Jung S, Johé P, Hellmich UA, Heilos A, Engels B, Krauth-Siegel RL, Dirdjaja N, Bou-Iserte L, Rodríguez S, González FV.

ACS Med Chem Lett. 2016 Sep 21;7(12):1073-1076. eCollection 2016 Dec 8.


Diverse relations between ABC transporters and lipids: An overview.

Neumann J, Rose-Sperling D, Hellmich UA.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):605-618. doi: 10.1016/j.bbamem.2016.09.023. Epub 2016 Sep 29. Review.


Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors.

Schirmeister T, Kesselring J, Jung S, Schneider TH, Weickert A, Becker J, Lee W, Bamberger D, Wich PR, Distler U, Tenzer S, Johé P, Hellmich UA, Engels B.

J Am Chem Soc. 2016 Jul 13;138(27):8332-5. doi: 10.1021/jacs.6b03052. Epub 2016 Jul 1.


The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.

Hacker C, Christ NA, Duchardt-Ferner E, Korn S, Göbl C, Berninger L, Düsterhus S, Hellmich UA, Madl T, Kötter P, Entian KD, Wöhnert J.

J Biol Chem. 2015 Nov 27;290(48):28869-86. doi: 10.1074/jbc.M115.679969. Epub 2015 Oct 12.


Effects of nucleotide binding to LmrA: A combined MAS-NMR and solution NMR study.

Hellmich UA, Mönkemeyer L, Velamakanni S, van Veen HW, Glaubitz C.

Biochim Biophys Acta. 2015 Dec;1848(12):3158-65. doi: 10.1016/j.bbamem.2015.10.003. Epub 2015 Oct 9.


High-resolution views of TRPV1 and their implications for the TRP channel superfamily.

Hellmich UA, Gaudet R.

Handb Exp Pharmacol. 2014;223:991-1004. doi: 10.1007/978-3-319-05161-1_11. Review.


Structural biology of TRP channels.

Hellmich UA, Gaudet R.

Handb Exp Pharmacol. 2014;223:963-90. doi: 10.1007/978-3-319-05161-1_10. Review.


Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis.

Hellmich UA, Weis BL, Lioutikov A, Wurm JP, Kaiser M, Christ NA, Hantke K, Kötter P, Entian KD, Schleiff E, Wöhnert J.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15253-8. doi: 10.1073/pnas.1306389110. Epub 2013 Sep 3.


Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9553-8. doi: 10.1073/pnas.1220231110. Epub 2013 May 20.


A lipid-dependent link between activity and oligomerization state of the M. tuberculosis SMR protein TBsmr.

Mörs K, Hellmich UA, Basting D, Marchand P, Wurm JP, Haase W, Glaubitz C.

Biochim Biophys Acta. 2013 Feb;1828(2):561-7. doi: 10.1016/j.bbamem.2012.10.020. Epub 2012 Oct 24.

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