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Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine.

Matthes E, Goepp J, Martini C, Shan J, Liao J, Thomas DY, Hanrahan JW.

Front Pharmacol. 2018 Dec 19;9:1490. doi: 10.3389/fphar.2018.01490. eCollection 2018.


A novel triple combination of pharmacological chaperones improves F508del-CFTR correction.

Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW, Thomas DY.

Sci Rep. 2018 Jul 30;8(1):11404. doi: 10.1038/s41598-018-29276-y.


F508del-CFTR is not corrected by thymosin α1.

Matthes E, Hanrahan JW, Cantin AM.

Nat Med. 2018 Jul;24(7):890-891. doi: 10.1038/s41591-018-0079-6. No abstract available.


Most bicarbonate secretion by Calu-3 cells is mediated by CFTR and independent of pendrin.

Huang J, Kim D, Shan J, Abu-Arish A, Luo Y, Hanrahan JW.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13641.


Velocity landscape correlation resolves multiple flowing protein populations from fluorescence image time series.

Pandžić E, Abu-Arish A, Whan RM, Hanrahan JW, Wiseman PW.

Methods. 2018 May 1;140-141:126-139. doi: 10.1016/j.ymeth.2018.02.011. Epub 2018 Feb 16.


Corrector combination therapies for F508del-CFTR.

Hanrahan JW, Matthes E, Carlile G, Thomas DY.

Curr Opin Pharmacol. 2017 Jun;34:105-111. doi: 10.1016/j.coph.2017.09.016. Epub 2017 Nov 5. Review.


Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells.

Wong FH, AbuArish A, Matthes E, Turner MJ, Greene LE, Cloutier A, Robert R, Thomas DY, Cosa G, Cantin AM, Hanrahan JW.

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C118-C134. doi: 10.1152/ajpcell.00099.2017. Epub 2017 Oct 4.


Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside.

Garić D, De Sanctis JB, Wojewodka G, Houle D, Cupri S, Abu-Arish A, Hanrahan JW, Hajduch M, Matouk E, Radzioch D.

J Mol Med (Berl). 2017 Oct;95(10):1053-1064. doi: 10.1007/s00109-017-1564-y. Epub 2017 Jul 10.


Thymosin α1: a single drug with multiple targets in cystic fibrosis.

Cantin AM, Hanrahan JW.

Nat Med. 2017 May 5;23(5):536-538. doi: 10.1038/nm.4339. No abstract available.


Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

Billet A, Froux L, Hanrahan JW, Becq F.

Front Pharmacol. 2017 Apr 7;8:195. doi: 10.3389/fphar.2017.00195. eCollection 2017.


PEGylated composite nanoparticles of PLGA and polyethylenimine for safe and efficient delivery of pDNA to lungs.

Kolte A, Patil S, Lesimple P, Hanrahan JW, Misra A.

Int J Pharm. 2017 May 30;524(1-2):382-396. doi: 10.1016/j.ijpharm.2017.03.094. Epub 2017 Apr 6.


β2-Adrenergic receptor agonists activate CFTR in intestinal organoids and subjects with cystic fibrosis.

Vijftigschild LA, Berkers G, Dekkers JF, Zomer-van Ommen DD, Matthes E, Kruisselbrink E, Vonk A, Hensen CE, Heida-Michel S, Geerdink M, Janssens HM, van de Graaf EA, Bronsveld I, de Winter-de Groot KM, Majoor CJ, Heijerman HG, de Jonge HR, Hanrahan JW, van der Ent CK, Beekman JM.

Eur Respir J. 2016 Sep;48(3):768-79. doi: 10.1183/13993003.01661-2015. Epub 2016 Jul 28.


Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V.

Mol Pharmacol. 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418. Epub 2016 May 18.


Investigating CFTR and KCa3.1 Protein/Protein Interactions.

Klein H, Abu-Arish A, Trinh NT, Luo Y, Wiseman PW, Hanrahan JW, Brochiero E, Sauvé R.

PLoS One. 2016 Apr 19;11(4):e0153665. doi: 10.1371/journal.pone.0153665. eCollection 2016.


Potential sites of CFTR activation by tyrosine kinases.

Billet A, Jia Y, Jensen TJ, Hou YX, Chang XB, Riordan JR, Hanrahan JW.

Channels (Austin). 2016;10(3):247-51. doi: 10.1080/19336950.2015.1126010. Epub 2015 Dec 8.


The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

Turner MJ, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70. doi: 10.1152/ajplung.00324.2015. Epub 2015 Nov 6.


Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

Matthes E, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW.

Br J Pharmacol. 2016 Feb;173(3):459-70. doi: 10.1111/bph.13365. Epub 2016 Jan 13.


Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells.

Abu-Arish A, Pandzic E, Goepp J, Matthes E, Hanrahan JW, Wiseman PW.

Biophys J. 2015 Jul 7;109(1):85-94. doi: 10.1016/j.bpj.2015.04.042.


Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.

Billet A, Jia Y, Jensen T, Riordan JR, Hanrahan JW.

FASEB J. 2015 Sep;29(9):3945-53. doi: 10.1096/fj.15-273151. Epub 2015 Jun 10.


Polymer assisted entrapment of netilmicin in PLGA nanoparticles for sustained antibacterial activity.

Kolate A, Kore G, Lesimple P, Baradia D, Patil S, Hanrahan JW, Misra A.

J Microencapsul. 2015;32(1):61-74. doi: 10.3109/02652048.2014.944951. Epub 2014 Sep 19.


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