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Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.

Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS.

Oncogene. 2020 Mar 23. doi: 10.1038/s41388-020-1272-x. [Epub ahead of print]


B-cells improve overall survival in HPV-associated squamous cell carcinomas and are activated by radiation and PD-1 blockade.

Kim SS, Shen S, Miyauchi S, Sanders PD, Franiak-Pietryga I, Mell L, Gutkind JS, Cohen EEW, Califano JA, Sharabi AB.

Clin Cancer Res. 2020 Mar 19. pii: clincanres.3211.2019. doi: 10.1158/1078-0432.CCR-19-3211. [Epub ahead of print]


Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling.

Stratman AN, Farrelly OM, Mikelis CM, Miller MF, Wang Z, Pham VN, Davis AE, Burns MC, Pezoa SA, Castranova D, Yano JJ, Kilts TM, Davis GE, Gutkind JS, Weinstein BM.

Nat Commun. 2020 Mar 5;11(1):1204. doi: 10.1038/s41467-020-14956-z.


Cannabinoids promote progression of HPV positive head and neck squamous cell carcinoma via p38 MAPK activation.

Liu C, Sadat SH, Ebisumoto K, Sakai A, Panuganti BA, Ren S, Goto Y, Haft S, Fukusumi T, Ando M, Saito Y, Guo T, Tamayo P, Yeerna H, Kim W, Hubbard J, Sharabi AB, Gutkind JS, Califano JA.

Clin Cancer Res. 2020 Jan 13. pii: clincanres.3301.2018. doi: 10.1158/1078-0432.CCR-18-3301. [Epub ahead of print]


HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer.

Miyauchi S, Sanders PD, Guram K, Kim SS, Paolini F, Venuti A, Cohen EEW, Gutkind JS, Califano JA, Sharabi AB.

Cancer Res. 2020 Feb 15;80(4):732-746. doi: 10.1158/0008-5472.CAN-19-1771. Epub 2019 Dec 17.


Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS.

Nat Commun. 2019 Dec 5;10(1):5546. doi: 10.1038/s41467-019-13471-0.


Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes.

Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S.

Clin Transl Gastroenterol. 2019 Nov;10(11):e00092. doi: 10.14309/ctg.0000000000000092.


Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes.

Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S.

Clin Transl Gastroenterol. 2019 Nov 11. doi: 10.14309/ctg.0000000000000092. [Epub ahead of print]


Activation of G-Protein Coupled Receptor-Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia.

Pedro MP, Salinas Parra N, Gutkind JS, Iglesias-Bartolome R.

J Invest Dermatol. 2019 Nov 7. pii: S0022-202X(19)33386-X. doi: 10.1016/j.jid.2019.10.012. [Epub ahead of print]


Targeting mTOR in Head and Neck Cancer-Response.

Gutkind JS, Day TA, Lippman SM, Szabo E.

Clin Cancer Res. 2019 Nov 1;25(21):6555. doi: 10.1158/1078-0432.CCR-19-2002. No abstract available.


Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold.

Cash JN, Urata S, Li S, Ravala SK, Avramova LV, Shost MD, Gutkind JS, Tesmer JJG, Cianfrocco MA.

Sci Adv. 2019 Oct 16;5(10):eaax8855. doi: 10.1126/sciadv.aax8855. eCollection 2019 Oct.


Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential.

Dongre H, Rana N, Fromreide S, Rajthala S, Bøe Engelsen I, Paradis J, Gutkind JS, Vintermyr OK, Johannessen AC, Bjørge L, Costea DE.

Exp Cell Res. 2020 Jan 1;386(1):111684. doi: 10.1016/j.yexcr.2019.111684. Epub 2019 Oct 23.


Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision.

D'Silva NJ, Gutkind JS.

Adv Dent Res. 2019 Nov;30(2):45-49. doi: 10.1177/0022034519877388.


Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.

Gulati S, Desai J, Palackdharry SM, Morris JC, Zhu Z, Jandarov R, Riaz MK, Takiar V, Mierzwa M, Gutkind JS, Molinolo A, Desai PB, Sadraei NH, Wise-Draper TM.

Cancer. 2020 Jan 15;126(2):354-362. doi: 10.1002/cncr.32539. Epub 2019 Oct 18.


Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance.

Zainal NS, Lee BKB, Wong ZW, Chin IS, Yee PS, Gan CP, Mun KS, Rahman ZAA, Gutkind JS, Patel V, Cheong SC.

Cancer Biol Med. 2019 May;16(2):264-275. doi: 10.20892/j.issn.2095-3941.2018.0257.


Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Zahra FT, Sajib MS, Ichiyama Y, Akwii RG, Tullar PE, Cobos C, Minchew SA, Doçi CL, Zheng Y, Kubota Y, Gutkind JS, Mikelis CM.

Sci Rep. 2019 Aug 12;9(1):11666. doi: 10.1038/s41598-019-48053-z.


Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer.

Magen A, Das Sahu A, Lee JS, Sharmin M, Lugo A, Gutkind JS, Schäffer AA, Ruppin E, Hannenhalli S.

Cell Rep. 2019 Jul 23;28(4):938-948.e6. doi: 10.1016/j.celrep.2019.06.067.


Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

Raimondi F, Inoue A, Kadji FMN, Shuai N, Gonzalez JC, Singh G, de la Vega AA, Sotillo R, Fischer B, Aoki J, Gutkind JS, Russell RB.

Oncogene. 2019 Sep;38(38):6491-6506. doi: 10.1038/s41388-019-0895-2. Epub 2019 Jul 23.


Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells.

Wu X, Yeerna H, Goto Y, Ando T, Wu VH, Zhang X, Wang Z, Amornphimoltham P, Murphy AN, Tamayo P, Chen Q, Lippman SM, Gutkind JS.

Cancer Res. 2019 Sep 1;79(17):4360-4370. doi: 10.1158/0008-5472.CAN-18-3525. Epub 2019 Jul 10.


Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy.

Wu V, Yeerna H, Nohata N, Chiou J, Harismendy O, Raimondi F, Inoue A, Russell RB, Tamayo P, Gutkind JS.

J Biol Chem. 2019 Jul 19;294(29):11062-11086. doi: 10.1074/jbc.REV119.005601. Epub 2019 Jun 5. Review.

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