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Items: 1 to 20 of 49


Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors.

Baid K, Nellimarla S, Huynh A, Boulton S, Guarné A, Melacini G, Collins SE, Mossman KL.

Immunol Cell Biol. 2018 Apr 4. doi: 10.1111/imcb.12052. [Epub ahead of print]


Molecular basis of human CD22 function and therapeutic targeting.

Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP.

Nat Commun. 2017 Oct 2;8(1):764. doi: 10.1038/s41467-017-00836-6.


Complementary uses of small angle X-ray scattering and X-ray crystallography.

Pillon MC, Guarné A.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1623-1630. doi: 10.1016/j.bbapap.2017.07.013. Epub 2017 Jul 22. Review.


The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly.

Razi A, Guarné A, Ortega J.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3396-E3403. doi: 10.1073/pnas.1618016114. Epub 2017 Apr 10.


Large-scale production of recombinant Saw1 in Escherichia coli.

Rashev M, Surtees JA, Guarné A.

Protein Expr Purif. 2017 May;133:75-80. doi: 10.1016/j.pep.2017.02.014. Epub 2017 Mar 2.


FHA domains: Phosphopeptide binding and beyond.

Almawi AW, Matthews LA, Guarné A.

Prog Biophys Mol Biol. 2017 Aug;127:105-110. doi: 10.1016/j.pbiomolbio.2016.12.003. Epub 2016 Dec 8. Review.


'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.

Almawi AW, Matthews LA, Larasati, Myrox P, Boulton S, Lai C, Moraes T, Melacini G, Ghirlando R, Duncker BP, Guarné A.

Sci Rep. 2016 Sep 29;6:34237. doi: 10.1038/srep34237.


Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.

Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.

Nucleic Acids Res. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542. Epub 2016 Jun 14.


Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD.

Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.


A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function.

Novakowski KE, Huynh A, Han S, Dorrington MG, Yin C, Tu Z, Pelka P, Whyte P, Guarné A, Sakamoto K, Bowdish DM.

Immunol Cell Biol. 2016 Aug;94(7):646-55. doi: 10.1038/icb.2016.20. Epub 2016 Feb 18.


Conformational toggling controls target site choice for the heteromeric transposase element Tn7.

Shi Q, Straus MR, Caron JJ, Wang H, Chung YS, Guarné A, Peters JE.

Nucleic Acids Res. 2015 Dec 15;43(22):10734-45. doi: 10.1093/nar/gkv913. Epub 2015 Sep 17.


The sliding clamp tethers the endonuclease domain of MutL to DNA.

Pillon MC, Babu VM, Randall JR, Cai J, Simmons LA, Sutton MD, Guarné A.

Nucleic Acids Res. 2015 Dec 15;43(22):10746-59. doi: 10.1093/nar/gkv918. Epub 2015 Sep 17.


Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F.

Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3.


Mismatch repair in Gram-positive bacteria.

Lenhart JS, Pillon MC, Guarné A, Biteen JS, Simmons LA.

Res Microbiol. 2016 Jan;167(1):4-12. doi: 10.1016/j.resmic.2015.08.006. Epub 2015 Sep 3. Review.


Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal.

Guarné A, Charbonnier JB.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):149-156. doi: 10.1016/j.pbiomolbio.2015.02.002. Epub 2015 Feb 18. Review.


Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.

Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F.

Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025.


Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease.

Rogacheva MV, Manhart CM, Chen C, Guarne A, Surtees J, Alani E.

J Biol Chem. 2014 Feb 28;289(9):5664-73. doi: 10.1074/jbc.M113.534644. Epub 2014 Jan 8.


A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins.

Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A.

J Biol Chem. 2014 Jan 31;289(5):2589-99. doi: 10.1074/jbc.M113.517060. Epub 2013 Nov 27.


Trapping and visualizing intermediate steps in the mismatch repair pathway in vivo.

Lenhart JS, Pillon MC, Guarné A, Simmons LA.

Mol Microbiol. 2013 Nov;90(4):680-98. doi: 10.1111/mmi.12389. Epub 2013 Sep 16.


Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.

Pillon MC, Dubinsky M, Johnston RN, Liu SL, Guarné A.

DNA Repair (Amst). 2013 Oct;12(10):864-9. doi: 10.1016/j.dnarep.2013.07.003. Epub 2013 Aug 2.


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