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Items: 1 to 20 of 306

1.

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS.

Mol Cell. 2017 Jun 22. pii: S1097-2765(17)30394-5. doi: 10.1016/j.molcel.2017.05.030. [Epub ahead of print]

PMID:
28648777
2.

DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation.

Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T.

Proc Natl Acad Sci U S A. 2017 Jun 23. pii: 201612980. doi: 10.1073/pnas.1612980114. [Epub ahead of print]

PMID:
28645898
3.

A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells.

Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B.

Nat Methods. 2017 Jun;14(6):629-635. doi: 10.1038/nmeth.4264. Epub 2017 Apr 17.

PMID:
28417999
4.

eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.

Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL.

Cancer Res. 2017 Apr 15;77(8):1997-2007. doi: 10.1158/0008-5472.CAN-16-2594. Epub 2017 Apr 5.

PMID:
28381547
5.

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade.

Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P.

Nat Cell Biol. 2017 Apr;19(4):362-374. doi: 10.1038/ncb3496. Epub 2017 Mar 27.

PMID:
28346439
6.

Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ.

Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL.

Cancer Res. 2017 May 1;77(9):2413-2423. doi: 10.1158/0008-5472.CAN-16-3229. Epub 2017 Mar 1.

PMID:
28249901
7.

L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.

Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00492-16. doi: 10.1128/MCB.00492-16. Print 2017 Apr 15.

PMID:
28137912
8.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27.

PMID:
28130546
9.

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.

Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q.

Autophagy. 2017 Mar 4;13(3):592-607. doi: 10.1080/15548627.2016.1269988. Epub 2017 Jan 6.

PMID:
28059666
10.

Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP.

Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL.

EMBO Rep. 2017 Jan;18(1):72-86. doi: 10.15252/embr.201642681. Epub 2016 Dec 15.

PMID:
27979971
11.

Characterization of Hippo Pathway Components by Gene Inactivation.

Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan KL.

Mol Cell. 2016 Dec 1;64(5):993-1008. doi: 10.1016/j.molcel.2016.10.034.

12.

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL.

Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.

PMID:
27912060
13.

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.

Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou LS, Groh BS, Liu WR, Ji MB, Ding C, Shi YH, Guan KL, Ye D, Xiong Y.

Cancer Res. 2016 Dec 1;76(23):6924-6936. Epub 2016 Oct 10.

PMID:
27758890
14.

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.

Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11525-11530. Epub 2016 Sep 26.

15.

Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination.

Zha Z, Han XR, Smith MD, Lei QY, Guan KL, Xiong Y.

Cell Discov. 2016 Apr 26;2:16005. doi: 10.1038/celldisc.2016.5. eCollection 2016.

16.

Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration.

Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL.

J Biol Chem. 2016 Sep 2;291(36):18947-58. doi: 10.1074/jbc.M116.739722. Epub 2016 Jul 5.

PMID:
27382053
17.

The Hippo pathway in intestinal regeneration and disease.

Hong AW, Meng Z, Guan KL.

Nat Rev Gastroenterol Hepatol. 2016 Jun;13(6):324-37. doi: 10.1038/nrgastro.2016.59. Epub 2016 May 5. Review.

PMID:
27147489
18.

Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation.

Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan KL, Zou J, Xu P.

Genes Dev. 2016 May 1;30(9):1086-100. doi: 10.1101/gad.277533.116. Epub 2016 Apr 28.

19.

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.

Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D.

EMBO Rep. 2016 Jun;17(6):811-22. doi: 10.15252/embr.201541643. Epub 2016 Apr 9.

20.

Glycoholics Anonymous: Cancer Sobers Up with mTORC1.

Fu V, Moroishi T, Guan KL.

Cancer Cell. 2016 Apr 11;29(4):432-4. doi: 10.1016/j.ccell.2016.03.016.

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