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Items: 19


Polymerase delta interacting protein 2 activates the RhoGEF Epithelial cell transforming sequence 2 in vascular smooth muscle cells.

Huff LP, Kikuchi DS, Faidley E, Forrester SJ, Tsai MZ, Lassègue B, Griendling KK.

Am J Physiol Cell Physiol. 2019 Feb 6. doi: 10.1152/ajpcell.00208.2018. [Epub ahead of print]


Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.

Forrester SJ, Xu Q, Kikuchi DS, Okwan-Duodu D, Campos AC, Faidley EA, Zhang G, Lassègue B, Sadikot RT, Griendling KK, Hernandes MS.

Clin Sci (Lond). 2019 Jan 25;133(2):321-334. doi: 10.1042/CS20180944. Print 2019 Jan 31.


High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Li L, Lai EY, Luo Z, Solis G, Mendonca M, Griendling KK, Wellstein A, Welch WJ, Wilcox CS.

Hypertension. 2018 Nov;72(5):1208-1216. doi: 10.1161/HYPERTENSIONAHA.118.11354.


NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.

Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2423-2434. doi: 10.1161/ATVBAHA.118.311668.


Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21.

Datla SR, L Hilenski L, Seidel-Rogol B, Dikalova AE, Harousseau M, Punkova L, Joseph G, Taylor WR, Lassègue B, Griendling KK.

Lab Invest. 2018 Sep 20. doi: 10.1038/s41374-018-0103-y. [Epub ahead of print]


Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway.

Paredes F, Lassègue B, Williams HC, Faidley EA, Benavides GA, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7460-E7461. doi: 10.1073/pnas.1807968115. Epub 2018 Jul 24. No abstract available.


Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.

Hernandes MS, Lassègue B, Hilenski LL, Adams J, Gao N, Kuan CY, Sun YY, Cheng L, Kikuchi DS, Yepes M, Griendling KK.

J Neuroinflammation. 2018 Feb 17;15(1):45. doi: 10.1186/s12974-017-1032-1.


Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.

Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1789-1794. doi: 10.1073/pnas.1720693115. Epub 2018 Feb 6.


Polymerase δ-interacting Protein 2: A Multifunctional Protein.

Hernandes MS, Lassègue B, Griendling KK.

J Cardiovasc Pharmacol. 2017 Jun;69(6):335-342. doi: 10.1097/FJC.0000000000000465. Review.


Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.

Li L, Lai EY, Luo Z, Solis G, Griendling KK, Taylor WR, Jose PA, Wellstein A, Welch WJ, Wilcox CS.

Kidney Int. 2017 Sep;92(3):625-633. doi: 10.1016/j.kint.2017.02.009. Epub 2017 Apr 7. Erratum in: Kidney Int. 2017 Dec;92(6):1558.


FGF Suppresses Poldip2 Expression in Osteoblasts.

Katsumura S, Izu Y, Yamada T, Griendling K, Harada K, Noda M, Ezura Y.

J Cell Biochem. 2017 Jul;118(7):1670-1677. doi: 10.1002/jcb.25813. Epub 2017 Mar 15.


Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells.

Fujii M, Amanso A, Abrahão TB, Lassègue B, Griendling KK.

J Mol Cell Cardiol. 2016 Mar;92:21-9. doi: 10.1016/j.yjmcc.2016.01.016. Epub 2016 Jan 19.


Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.

Datla SR, McGrail DJ, Vukelic S, Huff LP, Lyle AN, Pounkova L, Lee M, Seidel-Rogol B, Khalil MK, Hilenski LL, Terada LS, Dawson MR, Lassègue B, Griendling KK.

Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H945-57. doi: 10.1152/ajpheart.00918.2013. Epub 2014 Jul 25.


RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013. Epub 2014 May 28.


Polymerase δ-interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.

Amanso AM, Lassègue B, Joseph G, Landázuri N, Long JS, Weiss D, Taylor WR, Griendling KK.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1548-55. doi: 10.1161/ATVBAHA.114.303873. Epub 2014 May 22.


Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK.

PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014.


Polymerase delta interacting protein 2 sustains vascular structure and function.

Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132.


NADPH oxidases: functions and pathologies in the vasculature.

Lassègue B, Griendling KK.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):653-61. doi: 10.1161/ATVBAHA.108.181610. Epub 2009 Nov 12. Review.


Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.

Lyle AN, Deshpande NN, Taniyama Y, Seidel-Rogol B, Pounkova L, Du P, Papaharalambus C, Lassègue B, Griendling KK.

Circ Res. 2009 Jul 31;105(3):249-59. doi: 10.1161/CIRCRESAHA.109.193722. Epub 2009 Jul 2.

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