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The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.

Jones CG, Martynowycz MW, Hattne J, Fulton TJ, Stoltz BM, Rodriguez JA, Nelson HM, Gonen T.

ACS Cent Sci. 2018 Nov 28;4(11):1587-1592. doi: 10.1021/acscentsci.8b00760. Epub 2018 Nov 2.


MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.

Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M.

Proc Natl Acad Sci U S A. 2018 Dec 10. pii: 201806806. doi: 10.1073/pnas.1806806115. [Epub ahead of print]


MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter.

Liu S, Gonen T.

Commun Biol. 2018;1:38. doi: 10.1038/s42003-018-0040-8. Epub 2018 May 3.


MicroED: a versatile cryoEM method for structure determination.

Nannenga BL, Gonen T.

Emerg Top Life Sci. 2018 Apr 20;2(1):1-8. doi: 10.1042/ETLS20170082. Epub 2018 Feb 6.


From electron crystallography of 2D crystals to MicroED of 3D crystals.

Martynowycz MW, Gonen T.

Curr Opin Colloid Interface Sci. 2018 Mar;34:9-16. doi: 10.1016/j.cocis.2018.01.010. Epub 2018 Jan 31.


Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.

Lei HT, Ma J, Sanchez Martinez S, Gonen T.

Nat Struct Mol Biol. 2018 Jun;25(6):522-527. doi: 10.1038/s41594-018-0072-2. Epub 2018 Jun 5.


Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.

Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T.

Structure. 2018 May 1;26(5):759-766.e4. doi: 10.1016/j.str.2018.03.021. Epub 2018 Apr 26.


Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS.

Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12.


Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.

Liu Y, Gonen S, Gonen T, Yeates TO.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3362-3367. doi: 10.1073/pnas.1718825115. Epub 2018 Mar 5.


Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.


Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS.

Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20.


Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA.

Nat Struct Mol Biol. 2018 Feb;25(2):131-134. doi: 10.1038/s41594-017-0018-0. Epub 2018 Jan 15.


Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS.

J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27.


MicroED Structure of Au146(p-MBA)57 at Subatomic Resolution Reveals a Twinned FCC Cluster.

Vergara S, Lukes DA, Martynowycz MW, Santiago U, Plascencia-Villa G, Weiss SC, de la Cruz MJ, Black DM, Alvarez MM, López-Lozano X, Barnes CO, Lin G, Weissker HC, Whetten RL, Gonen T, Yacaman MJ, Calero G.

J Phys Chem Lett. 2017 Nov 16;8(22):5523-5530. doi: 10.1021/acs.jpclett.7b02621. Epub 2017 Oct 31.


The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.

Wright ZVF, McCarthy S, Dickman R, Reyes FE, Sanchez-Martinez S, Cryar A, Kilford I, Hall A, Takle AK, Topf M, Gonen T, Thalassinos K, Tabor AB.

J Am Chem Soc. 2017 Sep 20;139(37):13063-13075. doi: 10.1021/jacs.7b06506. Epub 2017 Sep 7.


Taking the measure of MicroED.

Rodriguez JA, Eisenberg DS, Gonen T.

Curr Opin Struct Biol. 2017 Oct;46:79-86. doi: 10.1016/ Epub 2017 Jun 22. Review.


Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T.

Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178.


Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.


Corrigendum: Design of a hyperstable 60-subunit protein icosahedron.

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature20108. Epub 2016 Oct 19. No abstract available.


MicroED opens a new era for biological structure determination.

Nannenga BL, Gonen T.

Curr Opin Struct Biol. 2016 Oct;40:128-135. doi: 10.1016/ Epub 2016 Oct 1. Review.

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