Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1966 1
1968 1
1975 2
1980 1
1981 1
1982 1
1986 1
1990 3
1991 6
1992 12
1993 14
1994 22
1995 21
1996 24
1997 27
1998 20
1999 21
2000 22
2001 25
2002 21
2003 20
2004 31
2005 26
2006 17
2007 17
2008 26
2009 22
2010 21
2011 20
2012 28
2013 14
2014 18
2015 23
2016 19
2017 19
2018 20
2019 24
2020 26
2021 28
2022 20
2023 19
2024 8

Text availability

Article attribute

Article type

Publication date

Search Results

659 results

Results by year

Filters applied: . Clear all
Page 1
Redox homeostasis maintained by GPX4 facilitates STING activation.
Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, Yu J, Zhao W. Jia M, et al. Nat Immunol. 2020 Jul;21(7):727-735. doi: 10.1038/s41590-020-0699-0. Epub 2020 Jun 15. Nat Immunol. 2020. PMID: 32541831
Here, we show that cellular redox homeostasis maintained by glutathione peroxidase 4 (GPX4) is required for STING activation. GPX4 deficiency enhanced cellular lipid peroxidation and thus specifically inhibited the cGAS-STING pathway. Concordantly, GPX4 deficiency inhibite …
Here, we show that cellular redox homeostasis maintained by glutathione peroxidase 4 (GPX4) is required for STING activation. GPX4 de …
Glutathione peroxidase and viral replication: implications for viral evolution and chemoprevention.
Diamond AM, Hu YJ, Mansur DB. Diamond AM, et al. Biofactors. 2001;14(1-4):205-10. doi: 10.1002/biof.5520140126. Biofactors. 2001. PMID: 11568458 Review.
It is likely that several of the biological effects of selenium are due to its effects on selenoprotein activity. While the effects of the anti-oxidant selenoprotein glutathione peroxidase (GPx) on inhibiting HIV activation have been well documented, it is clear that incre …
It is likely that several of the biological effects of selenium are due to its effects on selenoprotein activity. While the effects of the a …
"LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strategy.
Jarrott B, Head R, Pringle KG, Lumbers ER, Martin JH. Jarrott B, et al. Pharmacol Res Perspect. 2022 Feb;10(1):e00911. doi: 10.1002/prp2.911. Pharmacol Res Perspect. 2022. PMID: 35029046 Free PMC article. Review.
Infection of humans with SARS-CoV-2 virus causes a disease known colloquially as "COVID-19" with symptoms ranging from asymptomatic to severe pneumonia. ...Viral replication causes oxidative stress due to elevated levels of reactive oxygen species. ...
Infection of humans with SARS-CoV-2 virus causes a disease known colloquially as "COVID-19" with symptoms ranging from asymptomatic t …
TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation.
Deng T, Hu B, Wang X, Ding S, Lin L, Yan Y, Peng X, Zheng X, Liao M, Jin Y, Dong W, Gu J, Zhou J. Deng T, et al. Autophagy. 2022 Dec;18(12):2781-2798. doi: 10.1080/15548627.2022.2047384. Epub 2022 Mar 10. Autophagy. 2022. PMID: 35266845 Free PMC article.
Many viruses hijack the host ubiquitin system to enhance self-replication. In the present study, we found that Avibirnavirus VP3 protein was ubiquitinated during infection and supported virus replication by ubiquitination. Mass spectrometry and mutation analy …
Many viruses hijack the host ubiquitin system to enhance self-replication. In the present study, we found that Avibirnavirus VP3 prot …
Selenium, Selenoproteins and Viral Infection.
Guillin OM, Vindry C, Ohlmann T, Chavatte L. Guillin OM, et al. Nutrients. 2019 Sep 4;11(9):2101. doi: 10.3390/nu11092101. Nutrients. 2019. PMID: 31487871 Free PMC article. Review.
In many cases, ROS can, in turn, enhance viral replication leading to an amplification loop. Another important parameter for viral replication and pathogenicity is the nutritional status of the host. ...Selenium deficiency, which is the main regulator …
In many cases, ROS can, in turn, enhance viral replication leading to an amplification loop. Another important parameter for …
Glutathione and glutathione derivatives in immunotherapy.
Fraternale A, Brundu S, Magnani M. Fraternale A, et al. Biol Chem. 2017 Feb 1;398(2):261-275. doi: 10.1515/hsz-2016-0202. Biol Chem. 2017. PMID: 27514076 Review.
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. ...Altered intracellular GSH levels are observed in a wide range of pathologies, including several viral infections, as well as in aging, all of which are also characterized by an unb …
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. ...Altered intracellular GSH levels are observed i …
Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis.
Chen J, Fu J, Zhao S, Zhang X, Chao Y, Pan Q, Sun H, Zhang J, Li B, Xue T, Li J, Liu C. Chen J, et al. Vet Sci. 2023 Jul 11;10(7):456. doi: 10.3390/vetsci10070456. Vet Sci. 2023. PMID: 37505861 Free PMC article. Review.
Iron is a necessary element for many intracellular enzymes, involved in both cellular activities and viral replication. Ferroptosis, a programmed cell death mode distinct from apoptosis, necrosis, and pyroptosis, is characterized by lipid peroxide accumulation and d …
Iron is a necessary element for many intracellular enzymes, involved in both cellular activities and viral replication. Ferrop …
Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus.
Amatore D, Celestino I, Brundu S, Galluzzi L, Coluccio P, Checconi P, Magnani M, Palamara AT, Fraternale A, Nencioni L. Amatore D, et al. FASEB Bioadv. 2019 Mar 13;1(5):296-305. doi: 10.1096/fba.2018-00066. eCollection 2019 May. FASEB Bioadv. 2019. PMID: 32123833 Free PMC article.
Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. We first evaluated the concentration of GSH and cysteine in organs of old mice; then, the effect of the administration of the N-butanoyl GSH …
Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral infections. …
Redox-Modulating Agents in the Treatment of Viral Infections.
Checconi P, De Angelis M, Marcocci ME, Fraternale A, Magnani M, Palamara AT, Nencioni L. Checconi P, et al. Int J Mol Sci. 2020 Jun 8;21(11):4084. doi: 10.3390/ijms21114084. Int J Mol Sci. 2020. PMID: 32521619 Free PMC article. Review.
Different viruses break this equilibrium and induce an oxidative stress that in turn facilitates specific steps of the virus lifecycle and activates an inflammatory response. In this context, many studies highlighted the importance of redox-sensitive pathways as novel cell …
Different viruses break this equilibrium and induce an oxidative stress that in turn facilitates specific steps of the virus lifecycl …
Coxsackievirus B3 Exploits the Ubiquitin-Proteasome System to Facilitate Viral Replication.
Voss M, Braun V, Bredow C, Kloetzel PM, Beling A. Voss M, et al. Viruses. 2021 Jul 13;13(7):1360. doi: 10.3390/v13071360. Viruses. 2021. PMID: 34372566 Free PMC article.
Infection by RNA viruses causes extensive cellular reorganization, including hijacking of membranes to create membranous structures termed replication organelles, which support viral RNA synthesis and virion assembly. ...Furthermore, we show that the proteasome cont …
Infection by RNA viruses causes extensive cellular reorganization, including hijacking of membranes to create membranous structures termed …
659 results