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Med Hypotheses. 2013 Dec;81(6):1046-55. doi: 10.1016/j.mehy.2013.09.032. Epub 2013 Oct 5.

Brain "Globalopathies" cause mental disorders.

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Sha'ar Menashe Mental Health Center, Hadera, Israel; Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. Electronic address:


"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" that are divided into three major interdependent types (1) "Resting-State Networkpathies," in personality disorders, (2) "Entropiathies" in mood disorders, and (3) "Connectopathies" in psychosis and schizophrenia spectrum disorders. Novel approaches of processing signals from the brain are beginning to reveal brain organization in health and disease. For example a "small world network" has been described for optimal brain functions and breakdown of that organization might underlie relevant psychiatric manifestations. A novel diagnostic reformulation can be generated based on pathologies of whole brain organizations, such new brain related diagnostic nosology is testable and thus can be validated. Once validated Globalopathies can provide for "Global-therapies" i.e., interventions that can reorganize the brain and cure psychiatric disorders. The technology for such interventions is becoming available.

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