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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1912 2
1913 1
1914 1
1919 8
1920 5
1921 5
1922 1
1923 5
1924 1
1926 3
1927 9
1928 7
1929 7
1930 2
1931 5
1932 10
1933 11
1934 5
1935 10
1936 5
1937 9
1938 5
1939 7
1940 3
1941 6
1942 7
1943 6
1944 10
1945 18
1946 65
1947 71
1948 78
1949 40
1950 53
1951 59
1952 47
1953 55
1954 50
1955 61
1956 77
1957 64
1958 90
1959 96
1960 88
1961 121
1962 113
1963 164
1964 292
1965 329
1966 487
1967 744
1968 1131
1969 1410
1970 1592
1971 1961
1972 2180
1973 2486
1974 3012
1975 3577
1976 3872
1977 4041
1978 4570
1979 5028
1980 5684
1981 6313
1982 7204
1983 8630
1984 9732
1985 11443
1986 13100
1987 15926
1988 18723
1989 22798
1990 26825
1991 30064
1992 33666
1993 37400
1994 42087
1995 46402
1996 48580
1997 51557
1998 55395
1999 59309
2000 65395
2001 68053
2002 72140
2003 77447
2004 84865
2005 92605
2006 99433
2007 104713
2008 109377
2009 113504
2010 121666
2011 131771
2012 140898
2013 147194
2014 152780
2015 157511
2016 157557
2017 158064
2018 160652
2019 170019
2020 182172
2021 192694
2022 180008
2023 168234
2024 59811

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3,419,307 results

Results by year

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Page 1
New genes from old: asymmetric divergence of gene duplicates and the evolution of development.
Holland PW, Marlétaz F, Maeso I, Dunwell TL, Paps J. Holland PW, et al. Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713):20150480. doi: 10.1098/rstb.2015.0480. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 27994121 Free PMC article. Review.
Gene duplications and gene losses have been frequent events in the evolution of animal genomes, with the balance between these two dynamic processes contributing to major differences in gene number between species. After gene duplication, it is common …
Gene duplications and gene losses have been frequent events in the evolution of animal genomes, with the balance between these …
Resurrection from lethal knockouts: Bypass of gene essentiality.
Du LL. Du LL. Biochem Biophys Res Commun. 2020 Jul 30;528(3):405-412. doi: 10.1016/j.bbrc.2020.05.207. Epub 2020 Jun 4. Biochem Biophys Res Commun. 2020. PMID: 32507598 Review.
The most severe phenotypic consequence of gene knockout is lethality. Genes with a lethal knockout phenotype are called essential genes. Based on genome-wide knockout analyses in yeasts, up to approximately a quarter of genes in a genome can be essenti …
The most severe phenotypic consequence of gene knockout is lethality. Genes with a lethal knockout phenotype are called essent …
Engineered gene circuits.
Hasty J, McMillen D, Collins JJ. Hasty J, et al. Nature. 2002 Nov 14;420(6912):224-30. doi: 10.1038/nature01257. Nature. 2002. PMID: 12432407 Review.
These developments have signalled the emergence of a gene circuit discipline, which provides a framework for predicting and evaluating the dynamics of cellular processes. Synthetic gene networks will also lead to new logical forms of cellular control, which could ha …
These developments have signalled the emergence of a gene circuit discipline, which provides a framework for predicting and evaluatin …
Resistance gene-dependent plant defense responses.
Hammond-Kosack KE, Jones JD. Hammond-Kosack KE, et al. Plant Cell. 1996 Oct;8(10):1773-91. doi: 10.1105/tpc.8.10.1773. Plant Cell. 1996. PMID: 8914325 Free PMC article. Review. No abstract available.
Breast cancer genes: beyond BRCA1 and BRCA2.
Filippini SE, Vega A. Filippini SE, et al. Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1358-72. doi: 10.2741/4185. Front Biosci (Landmark Ed). 2013. PMID: 23747889 Free article. Review.
Familial breast cancer (about 30 percent of patients), often seen in families with a high incidence of BC, has been associated with a number of high-, moderate-, and low-penetrance susceptibility genes. Family linkage studies have identified high-penetrance genes, B …
Familial breast cancer (about 30 percent of patients), often seen in families with a high incidence of BC, has been associated with a number …
Gene therapy progress and prospects: transcription regulatory systems.
Toniatti C, Bujard H, Cortese R, Ciliberto G. Toniatti C, et al. Gene Ther. 2004 Apr;11(8):649-57. doi: 10.1038/sj.gt.3302251. Gene Ther. 2004. PMID: 14985790 Review.
The clinical efficacy and safety as well as the application range of gene therapy will be broadened by developing systems capable of finely modulating the expression of therapeutic genes. Transgene regulation will be crucial for maintaining appropriate levels of a …
The clinical efficacy and safety as well as the application range of gene therapy will be broadened by developing systems capable of …
Gene regulatory networks.
Davidson E, Levin M. Davidson E, et al. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4935. doi: 10.1073/pnas.0502024102. Epub 2005 Apr 4. Proc Natl Acad Sci U S A. 2005. PMID: 15809445 Free PMC article. No abstract available.
Gene delivery by lentivirus vectors an overview.
Kafri T. Kafri T. Methods Mol Biol. 2004;246:367-90. doi: 10.1385/1-59259-650-9:367. Methods Mol Biol. 2004. PMID: 14970605 Review.
The ability of a replication competent retrovirus to incorporate a herpes simplex virus thymidine kinase (tk) gene into the genome of a mouse cell and to convert NIH-3T3 TK- cells into TK+ transformants was first described in 1981 (1,2). These studies established the basis …
The ability of a replication competent retrovirus to incorporate a herpes simplex virus thymidine kinase (tk) gene into the genome of …
Approaches to gene transfer in keratinocytes.
Fenjves ES. Fenjves ES. J Invest Dermatol. 1994 Nov;103(5 Suppl):70S-75S. doi: 10.1111/1523-1747.ep12399089. J Invest Dermatol. 1994. PMID: 7963688 Free article. Review.
The introduction and expression of exogenous genetic material in cultured cells has provided a powerful tool for studying gene function and regulation. Immortalized cell lines have been useful for establishing gene transfer methodologies that are generally inefficie …
The introduction and expression of exogenous genetic material in cultured cells has provided a powerful tool for studying gene functi …
Regulation of MHC gene expression.
Ting JP, Baldwin AS. Ting JP, et al. Curr Opin Immunol. 1993 Feb;5(1):8-16. doi: 10.1016/0952-7915(93)90074-3. Curr Opin Immunol. 1993. PMID: 8452678 Review.
The better characterization of proteins that interact with MHC class I and II promoters and the isolation of genes encoding several of these transcription factors, such as H-2RIIBP/RXR beta, NK kappa B, I-kappa B, hXBP-1 and NF-Y, allow the functional analysis of these mol …
The better characterization of proteins that interact with MHC class I and II promoters and the isolation of genes encoding several o …
3,419,307 results
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