Format

Send to

Choose Destination
J Exp Med. 2005 Mar 21;201(6):841-3.

Identifying genes that regulate bone remodeling as potential therapeutic targets.

Author information

1
Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129, USA. krane.stephen@mgh.harvard.edu

Abstract

Bone remodeling, a coupled process involving bone resorption and formation, is initiated by mechanical signals and is controlled by local and systemic factors that regulate osteoblast and osteoclast differentiation and function. An excess of resorption over formation leads to the bone loss and increased propensity to fracture that is characteristic of osteoporosis. A newly described inhibitor of osteoblast differentiation, Ciz, interferes with bone morphogenic protein signaling. As a consequence, Ciz-deficient mice develop increased bone mass.

PMID:
15781576
PMCID:
PMC2213103
DOI:
10.1084/jem.20050354
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center