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HMGB1 promotes bone fracture healing through activation of ERK signaling pathway in a rat tibial fracture model.

Chen MQ, Luan JJ.

Kaohsiung J Med Sci. 2019 Sep;35(9):550-558. doi: 10.1002/kjm2.12095. Epub 2019 Jun 4.


Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma.

Mangum LH, Avila JJ, Hurtgen BJ, Lofgren AL, Wenke JC.

J Orthop Surg Res. 2019 Feb 19;14(1):58. doi: 10.1186/s13018-019-1082-4.


RAGE Signaling in Skeletal Biology.

Plotkin LI, Essex AL, Davis HM.

Curr Osteoporos Rep. 2019 Feb;17(1):16-25. doi: 10.1007/s11914-019-00499-w. Review.


Systemic lidocaine inhibits high-mobility group box 1 messenger ribonucleic acid expression and protein in BALB/c mice after closed fracture musculoskeletal injury.

Sirait RH, Hatta M, Ramli M, Islam AA, Arief SK.

Saudi J Anaesth. 2018 Jul-Sep;12(3):395-398. doi: 10.4103/sja.SJA_685_17.


Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert.

Lee G, Espirito Santo AI, Zwingenberger S, Cai L, Vogl T, Feldmann M, Horwood NJ, Chan JK, Nanchahal J.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4463-E4472. doi: 10.1073/pnas.1802893115. Epub 2018 Apr 19.


Differential expression of alarmins-S100A9, IL-33, HMGB1 and HIF-1α in supraspinatus tendinopathy before and after treatment.

Mosca MJ, Carr AJ, Snelling SJB, Wheway K, Watkins B, Dakin SG.

BMJ Open Sport Exerc Med. 2017 May 31;3(1):e000225. doi: 10.1136/bmjsem-2017-000225. eCollection 2017.


Role of Hemorrhagic Shock in Experimental Polytrauma.

Denk S, Weckbach S, Eisele P, Braun CK, Wiegner R, Ohmann JJ, Wrba L, Hoenes FM, Kellermann P, Radermacher P, Wachter U, Hafner S, McCook O, Schultze A, Palmer A, Braumüller S, Gebhard F, Huber-Lang M.

Shock. 2018 Feb;49(2):154-163. doi: 10.1097/SHK.0000000000000925.


Local delivery of HMGB1 in gelatin sponge scaffolds combined with mesenchymal stem cell sheets to accelerate fracture healing.

Xue D, Zhang W, Chen E, Gao X, Liu L, Ye C, Tan Y, Pan Z, Li H.

Oncotarget. 2017 Jun 27;8(26):42098-42115. doi: 10.18632/oncotarget.16887.


HMGB1 promotes the secretion of multiple cytokines and potentiates the osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway.

Feng L, Xue D, Chen E, Zhang W, Gao X, Yu J, Feng Y, Pan Z.

Exp Ther Med. 2016 Dec;12(6):3941-3947. doi: 10.3892/etm.2016.3857. Epub 2016 Nov 2.


HMGB1 promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via Rap1 activation.

Lin F, Xue D, Xie T, Pan Z.

Mol Med Rep. 2016 Aug;14(2):1283-9. doi: 10.3892/mmr.2016.5398. Epub 2016 Jun 13.


Long-Term Effects of Induced Hypothermia on Local and Systemic Inflammation - Results from a Porcine Long-Term Trauma Model.

Horst K, Eschbach D, Pfeifer R, Relja B, Sassen M, Steinfeldt T, Wulf H, Vogt N, Frink M, Ruchholtz S, Pape HC, Hildebrand F.

PLoS One. 2016 May 4;11(5):e0154788. doi: 10.1371/journal.pone.0154788. eCollection 2016.


Tissue damage negatively regulates LPS-induced macrophage necroptosis.

Li Z, Scott MJ, Fan EK, Li Y, Liu J, Xiao G, Li S, Billiar TR, Wilson MA, Jiang Y, Fan J.

Cell Death Differ. 2016 Sep 1;23(9):1428-47. doi: 10.1038/cdd.2016.21. Epub 2016 Mar 4.


Signaling pathways involved in the effects of HMGB1 on mesenchymal stem cell migration and osteoblastic differentiation.

Lin F, Zhang W, Xue D, Zhu T, Li J, Chen E, Yao X, Pan Z.

Int J Mol Med. 2016 Mar;37(3):789-97. doi: 10.3892/ijmm.2016.2479. Epub 2016 Feb 3.


Bone Fracture Enhances Trauma Brain Injury.

Yang L, Guo Y, Wen D, Yang L, Chen Y, Zhang G, Fan Z.

Scand J Immunol. 2016 Jan;83(1):26-32. doi: 10.1111/sji.12393.


Impact of haemorrhagic shock intensity on the dynamic of alarmins release in porcine poly-trauma animal model.

Horst K, Hildebrand F, Pfeifer R, Hübenthal S, Almahmoud K, Sassen M, Steinfeldt T, Wulf H, Ruchholtz S, Pape HC, Eschbach D.

Eur J Trauma Emerg Surg. 2016 Feb;42(1):67-75. doi: 10.1007/s00068-015-0504-1. Epub 2015 Feb 28.


Local inflammation in fracture hematoma: results from a combined trauma model in pigs.

Horst K, Eschbach D, Pfeifer R, Hübenthal S, Sassen M, Steinfeldt T, Wulf H, Ruchholtz S, Pape HC, Hildebrand F.

Mediators Inflamm. 2015;2015:126060. doi: 10.1155/2015/126060. Epub 2015 Jan 28.


Is it appropriate to use fear conditioning to assess behavior impairment in fracture rat models?

He Y, Li Z, Zuo YX.

Anesthesiology. 2014 Dec;121(6):1353. doi: 10.1097/ALN.0000000000000452. No abstract available.


Bone fracture exacerbates murine ischemic cerebral injury.

Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H.

Anesthesiology. 2013 Jun;118(6):1362-72. doi: 10.1097/ALN.0b013e31828c23f8.


Resolving postoperative neuroinflammation and cognitive decline.

Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M.

Ann Neurol. 2011 Dec;70(6):986-995. doi: 10.1002/ana.22664.

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