Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Fertil Steril. 2014 Nov;102(5):1404-9. doi: 10.1016/j.fertnstert.2014.07.1253. Epub 2014 Sep 17.

First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.

Author information

1
Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: mathieu.luyckx@uclouvain.be.
2
Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
3
Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
4
Société de Recherche pour l'Infertilité, Brussels, Belgium.

Abstract

OBJECTIVE:

To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.

DESIGN:

Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

SETTING:

Academic hospital.

PATIENT(S):

Among the 52 patients, 21 wished to conceive upon treatment completion.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Pregnancy rate and live birth rate.

RESULT(S):

Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.

CONCLUSION(S):

We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.

KEYWORDS:

Fibroids; pregnancy; selective progesterone receptor modulators (SPRMs); ulipristal acetate

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center