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Items: 1 to 20 of 160

1.

A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition.

Mohr G, Silas S, Stamos JL, Makarova KS, Markham LM, Yao J, Lucas-Elío P, Sanchez-Amat A, Fire AZ, Koonin EV, Lambowitz AM.

Mol Cell. 2018 Nov 15;72(4):700-714.e8. doi: 10.1016/j.molcel.2018.09.013. Epub 2018 Oct 18.

PMID:
30344094
2.

Correction: Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems.

Silas S, Lucas-Elio P, Jackson SA, Aroca-Crevillén A, Hansen LL, Fineran PC, Fire AZ, Sánchez-Amat A.

Elife. 2018 Apr 4;7. pii: e36853. doi: 10.7554/eLife.36853. No abstract available.

3.

A Small RNA Isolation and Sequencing Protocol and Its Application to Assay CRISPR RNA Biogenesis in Bacteria.

Silas S, Jain N, Stadler M, Fu BXH, Sánchez-Amat A, Fire AZ, Arribere J.

Bio Protoc. 2018 Feb 20;8(4). pii: e2727. doi: 10.21769/BioProtoc.2727.

4.

Nonsense mRNA suppression via nonstop decay.

Arribere JA, Fire AZ.

Elife. 2018 Jan 8;7. pii: e33292. doi: 10.7554/eLife.33292.

5.

A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia.

Chung A, Hou Y, Ohgami RS, Von Gehr A, Fisk DG, Roskin KM, Li X, Gojenola L, Bangs CD, Arber DA, Fire AZ, Cherry AM, Zehnder JL, Gotlib J, Merker JD.

Cancer Genet. 2017 Oct;216-217:10-15. doi: 10.1016/j.cancergen.2017.05.001. Epub 2017 May 10.

PMID:
29025582
6.

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems.

Silas S, Lucas-Elio P, Jackson SA, Aroca-Crevillén A, Hansen LL, Fineran PC, Fire AZ, Sánchez-Amat A.

Elife. 2017 Aug 17;6. pii: e27601. doi: 10.7554/eLife.27601. Erratum in: Elife. 2018 Apr 04;7:.

7.

Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens.

Shoura MJ, Gabdank I, Hansen L, Merker J, Gotlib J, Levene SD, Fire AZ.

G3 (Bethesda). 2017 Oct 5;7(10):3295-3303. doi: 10.1534/g3.117.300141.

8.

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires.

Silas S, Makarova KS, Shmakov S, Páez-Espino D, Mohr G, Liu Y, Davison M, Roux S, Krishnamurthy SR, Fu BXH, Hansen LL, Wang D, Sullivan MB, Millard A, Clokie MR, Bhaya D, Lambowitz AM, Kyrpides NC, Koonin EV, Fire AZ.

MBio. 2017 Jul 11;8(4). pii: e00897-17. doi: 10.1128/mBio.00897-17.

9.

High-Throughput Characterization of Cascade type I-E CRISPR Guide Efficacy Reveals Unexpected PAM Diversity and Target Sequence Preferences.

Fu BX, Wainberg M, Kundaje A, Fire AZ.

Genetics. 2017 Aug;206(4):1727-1738. doi: 10.1534/genetics.117.202580. Epub 2017 Jun 20.

10.

Sequence-Modified Antibiotic Resistance Genes Provide Sustained Plasmid-Mediated Transgene Expression in Mammals.

Lu J, Zhang F, Fire AZ, Kay MA.

Mol Ther. 2017 May 3;25(5):1187-1198. doi: 10.1016/j.ymthe.2017.03.003. Epub 2017 Mar 30.

11.

An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline.

Frøkjær-Jensen C, Jain N, Hansen L, Davis MW, Li Y, Zhao D, Rebora K, Millet JRM, Liu X, Kim SK, Dupuy D, Jorgensen EM, Fire AZ.

Cell. 2016 Jul 14;166(2):343-357. doi: 10.1016/j.cell.2016.05.072. Epub 2016 Jun 30.

12.

Translation readthrough mitigation.

Arribere JA, Cenik ES, Jain N, Hess GT, Lee CH, Bassik MC, Fire AZ.

Nature. 2016 Jun 30;534(7609):719-23. Epub 2016 Jun 1.

13.

Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo.

Fu BX, St Onge RP, Fire AZ, Smith JD.

Nucleic Acids Res. 2016 Jun 20;44(11):5365-77. doi: 10.1093/nar/gkw417. Epub 2016 May 19.

14.

A streamlined tethered chromosome conformation capture protocol.

Gabdank I, Ramakrishnan S, Villeneuve AM, Fire AZ.

BMC Genomics. 2016 Apr 1;17:274. doi: 10.1186/s12864-016-2596-3.

15.

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.

Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C; NISC Comparative Sequencing Program, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF.

Cell. 2016 Apr 7;165(2):449-63. doi: 10.1016/j.cell.2016.02.022. Epub 2016 Mar 3.

16.

Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase-Cas1 fusion protein.

Silas S, Mohr G, Sidote DJ, Markham LM, Sanchez-Amat A, Bhaya D, Lambowitz AM, Fire AZ.

Science. 2016 Feb 26;351(6276):aad4234. doi: 10.1126/science.aad4234.

17.

Cas9 Variants Expand the Target Repertoire in Caenorhabditis elegans.

Bell RT, Fu BX, Fire AZ.

Genetics. 2016 Feb;202(2):381-8. doi: 10.1534/genetics.115.185041. Epub 2015 Dec 17. Erratum in: Genetics. 2016 Jun;203(2):999.

18.

Chikungunya Virus Sequences Across the First Epidemic in Nicaragua, 2014-2015.

Wang C, Saborio S, Gresh L, Eswarappa M, Wu D, Fire A, Parameswaran P, Balmaseda A, Harris E.

Am J Trop Med Hyg. 2016 Feb;94(2):400-3. doi: 10.4269/ajtmh.15-0497. Epub 2015 Dec 7.

19.

Associations between nucleosome phasing, sequence asymmetry, and tissue-specific expression in a set of inbred Medaka species.

Nakatani Y, Mello CC, Hashimoto S, Shimada A, Nakamura R, Tsukahara T, Qu W, Yoshimura J, Suzuki Y, Sugano S, Takeda H, Fire A, Morishita S.

BMC Genomics. 2015 Nov 19;16:978. doi: 10.1186/s12864-015-2198-5.

20.

Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy.

Levin M, King JJ, Glanville J, Jackson KJ, Looney TJ, Hoh RA, Mari A, Andersson M, Greiff L, Fire AZ, Boyd SD, Ohlin M.

J Allergy Clin Immunol. 2016 May;137(5):1535-44. doi: 10.1016/j.jaci.2015.09.027. Epub 2015 Nov 11.

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