Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 10
1981 5
1982 18
1983 24
1984 25
1985 28
1986 28
1987 29
1988 28
1989 47
1990 32
1991 44
1992 38
1993 43
1994 62
1995 59
1996 48
1997 45
1998 46
1999 60
2000 58
2001 64
2002 69
2003 64
2004 120
2005 65
2006 69
2007 70
2008 86
2009 103
2010 92
2011 112
2012 124
2013 154
2014 150
2015 165
2016 175
2017 178
2018 186
2019 206
2020 247
2021 261
2022 221
2023 235
2024 68

Text availability

Article attribute

Article type

Publication date

Search Results

3,640 results

Results by year

Filters applied: . Clear all
Page 1
Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2.
Zhu W, Sahar NE, Javaid HMA, Pak ES, Liang G, Wang Y, Ha H, Huh JY. Zhu W, et al. Cells. 2021 Nov 25;10(12):3306. doi: 10.3390/cells10123306. Cells. 2021. PMID: 34943814 Free PMC article.
The MD2-TLR4 pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise is considered to improve NAFLD but the underlying mechanism is still unclear. ...Our study provides novel evidence that exercise-induced irisin inhibits inflammation via …
The MD2-TLR4 pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise is considered to improve NAFLD but t …
Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-kappaB signaling.
Li Q, Tan Y, Chen S, Xiao X, Zhang M, Wu Q, Dong M. Li Q, et al. J Recept Signal Transduct Res. 2021 Jun;41(3):294-303. doi: 10.1080/10799893.2020.1808675. Epub 2020 Aug 19. J Recept Signal Transduct Res. 2021. PMID: 32814473
Lipopolysaccharide (LPS) provokes severe inflammation and cell death in sepsis, with liver being the major affected organ. ...Increased activity of NLRP3 inflammasome was discovered in LPS-challenged Raw264.7 cells, along with elevated levels of inflammation and apo …
Lipopolysaccharide (LPS) provokes severe inflammation and cell death in sepsis, with liver being the major affected organ. ...Increas …
Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism.
Xiong X, Lu L, Wang Z, Ma J, Shao Y, Liu Y, Zhai M, Jin P, Yang J, Zheng Q, Liu J, Yang L. Xiong X, et al. Biomed Pharmacother. 2022 Aug;152:113199. doi: 10.1016/j.biopha.2022.113199. Epub 2022 May 30. Biomed Pharmacother. 2022. PMID: 35653888 Free article.
However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5) that protects the heart from ischemia/reperfusion injury through upregulation of mitochondrial ubiquit …
However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type II …
Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability.
Chi C, Fu H, Li YH, Zhang GY, Zeng FY, Ji QX, Shen QR, Wang XJ, Li ZC, Zhou CC, Sun DY, Fu JT, Wu WB, Zhang PP, Zhang JB, Liu J, Shen FM, Li DJ, Wang P. Chi C, et al. Eur Heart J. 2022 Nov 14;43(43):4579-4595. doi: 10.1093/eurheartj/ehac431. Eur Heart J. 2022. PMID: 35929617
AIMS: Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate the role of fibronectin type-III domain-containing protein 5 (FNDC5)/irisin, an exercise-associated hormone, in vascular ageing. ... …
AIMS: Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate …
Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice.
Han F, Ding ZF, Shi XL, Zhu QT, Shen QH, Xu XM, Zhang JX, Gong WJ, Xiao WM, Wang D, Chen WW, Hu LH, Lu GT. Han F, et al. Redox Biol. 2023 Aug;64:102787. doi: 10.1016/j.redox.2023.102787. Epub 2023 Jun 23. Redox Biol. 2023. PMID: 37392517 Free PMC article.
INTRODUCTION: Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases through macrophage regulation. However, the effect of irisin on the activity of inflammation related immune cells (such as neutrophils) h …
INTRODUCTION: Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases thro …
Irisin, Exercise, and COVID-19.
Alves HR, Lomba GSB, Gonçalves-de-Albuquerque CF, Burth P. Alves HR, et al. Front Endocrinol (Lausanne). 2022 Jun 17;13:879066. doi: 10.3389/fendo.2022.879066. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35784579 Free PMC article. Review.
Irisin is thermogenic adipomyokine, improves glucose and lipid metabolism, and ameliorates the effects of obesity-driven inflammation, metabolic syndrome, and diabetes. In addition, exercise-induced irisin activates anti-inflammatory pathways and may play an essential role …
Irisin is thermogenic adipomyokine, improves glucose and lipid metabolism, and ameliorates the effects of obesity-driven inflammation
Irisin/FNDC5--An updated review.
Panati K, Suneetha Y, Narala VR. Panati K, et al. Eur Rev Med Pharmacol Sci. 2016;20(4):689-97. Eur Rev Med Pharmacol Sci. 2016. PMID: 26957272 Free article. Review.
OBJECTIVE: The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing 5 (FNDC5) of skeletal muscle by an unknown protease. ...Apart from this, its expression and role in various other conditions such as infl
OBJECTIVE: The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing …
3,640 results