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Items: 16

1.

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L.

J Med Chem. 2018 Jun 14;61(11):4739-4756. doi: 10.1021/acs.jmedchem.7b01839. Epub 2018 May 30.

PMID:
29746130
2.

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

Sahu NU, Singh V, Ferraris DM, Rizzi M, Kharkar PS.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1714-1718. doi: 10.1016/j.bmcl.2018.04.045. Epub 2018 Apr 18.

PMID:
29699922
3.

Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.

Rossi F, Morrone C, Massarotti A, Ferraris DM, Valenti A, Perugino G, Miggiano R.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):698-703. doi: 10.1016/j.bbrc.2018.04.139. Epub 2018 Apr 30.

PMID:
29684348
4.

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

Mori M, Deodato D, Kasula M, Ferraris DM, Sanna A, De Logu A, Rizzi M, Botta M.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):637-641. doi: 10.1016/j.bmcl.2018.01.031. Epub 2018 Jan 31.

PMID:
29395975
5.

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets.

Ferraris DM, Miggiano R, Rossi F, Rizzi M.

Pathogens. 2018 Feb 1;7(1). pii: E17. doi: 10.3390/pathogens7010017. Review.

6.

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages.

Paolino M, Brindisi M, Vallone A, Butini S, Campiani G, Nannicini C, Giuliani G, Anzini M, Lamponi S, Giorgi G, Sbardella D, Ferraris DM, Marini S, Coletta M, Palucci I, Minerva M, Delogu G, Pepponi I, Goletti D, Cappelli A, Gemma S, Brogi S.

ChemMedChem. 2018 Mar 6;13(5):422-430. doi: 10.1002/cmdc.201700759. Epub 2018 Feb 14.

PMID:
29334428
7.

Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.

Donini S, Ferraris DM, Miggiano R, Massarotti A, Rizzi M.

Sci Rep. 2017 Apr 26;7(1):1180. doi: 10.1038/s41598-017-01057-z.

8.

Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.

Donini S, Garavaglia S, Ferraris DM, Miggiano R, Mori S, Shibayama K, Rizzi M.

PLoS One. 2017 Apr 18;12(4):e0175815. doi: 10.1371/journal.pone.0175815. eCollection 2017.

9.

Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.

Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M.

Proteins. 2015 Feb;83(2):389-94. doi: 10.1002/prot.24743. Epub 2015 Jan 7.

PMID:
25524525
10.

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

Mori M, Moraca F, Deodato D, Ferraris DM, Selchow P, Sander P, Rizzi M, Botta M.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2508-11. doi: 10.1016/j.bmcl.2014.04.004. Epub 2014 Apr 13.

PMID:
24767848
11.

Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.

Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M.

Proteins. 2014 Sep;82(9):2268-74. doi: 10.1002/prot.24548. Epub 2014 Mar 24.

PMID:
24615888
12.

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells.

Dietz MS, Haße D, Ferraris DM, Göhler A, Niemann HH, Heilemann M.

BMC Biophys. 2013 Jun 3;6(1):6. doi: 10.1186/2046-1682-6-6.

13.

Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates.

Petrera A, Amstutz B, Gioia M, Hähnlein J, Baici A, Selchow P, Ferraris DM, Rizzi M, Sbardella D, Marini S, Coletta M, Sander P.

Biol Chem. 2012 Jul;393(7):631-40. doi: 10.1515/hsz-2012-0106.

14.

Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity.

Ferraris DM, Sbardella D, Petrera A, Marini S, Amstutz B, Coletta M, Sander P, Rizzi M.

J Biol Chem. 2011 Sep 16;286(37):32475-82. doi: 10.1074/jbc.M111.271809. Epub 2011 Aug 3.

15.

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

Ferraris DM, Gherardi E, Di Y, Heinz DW, Niemann HH.

J Mol Biol. 2010 Jan 22;395(3):522-32. doi: 10.1016/j.jmb.2009.10.074. Epub 2009 Nov 6.

PMID:
19900460
16.

Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.

Niemann HH, Jäger V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW.

Cell. 2007 Jul 27;130(2):235-46.

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