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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 5
2005 4
2006 3
2007 3
2008 5
2009 8
2010 3
2011 8
2012 7
2013 10
2014 15
2015 12
2016 8
2017 15
2018 11
2019 9
2020 12
2021 12
2022 7
2023 7
2024 3

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142 results

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Page 1
FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.
Habel N, El-Hachem N, Soysouvanh F, Hadhiri-Bzioueche H, Giuliano S, Nguyen S, Horák P, Gay AS, Debayle D, Nottet N, Béranger G, Paillerets BB, Bertolotto C, Ballotti R. Habel N, et al. Cell Death Differ. 2021 Jun;28(6):1837-1848. doi: 10.1038/s41418-020-00710-x. Epub 2021 Jan 18. Cell Death Differ. 2021. PMID: 33462405 Free PMC article.
FBXO32 favors melanoma cell migration, proliferation, and tumor development in vivo. ...FBXO32 and SMARCA4 co-localize at loci regulated by FBXO32, such as CDK6 suggesting that FBXO32 controls transcription through the regulation of chromatin re …
FBXO32 favors melanoma cell migration, proliferation, and tumor development in vivo. ...FBXO32 and SMARCA4 co-localize …
The atypical ubiquitin ligase RNF31 stabilizes c-Myc via epigenetic inactivation of FBXO32 and promotes cancer development.
Chen Z, Ren D, Lv J, Xu Y, Xie M, He X, Shi W, Qian Q, Jing A, Ma X, Qin J, Ding Y, Geng T, Ma J, Liu W, Liu S, Ji J. Chen Z, et al. Cell Signal. 2023 Jul;107:110677. doi: 10.1016/j.cellsig.2023.110677. Epub 2023 Apr 5. Cell Signal. 2023. PMID: 37028779
We found that RNF31 inhibited the transcription of FBXO32 through EZH2-mediated trimethylation of histone H3K27 in the FBXO32 promoter region, leading to the stabilization and activation of c-Myc protein. ...Consistent with these results, the reduced malignancy phen …
We found that RNF31 inhibited the transcription of FBXO32 through EZH2-mediated trimethylation of histone H3K27 in the FBXO32 …
DNMT1-mediated regulating on FBXO32 promotes the progression of glioma cells through the regulation of SKP1 activity.
Quan J, Ma C. Quan J, et al. Environ Toxicol. 2024 Feb;39(2):783-793. doi: 10.1002/tox.23976. Epub 2023 Oct 2. Environ Toxicol. 2024. PMID: 37782699
Furthermore, a xenograft model established by injecting glioma cells stably transfected with FBXO32 was used to evaluate tumor growth, volume, and weight. The ChIP assay was employed to study the interaction between DNMT1 and the FBXO32 promoter, revealing that DNMT …
Furthermore, a xenograft model established by injecting glioma cells stably transfected with FBXO32 was used to evaluate tumor growth …
FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation.
Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, Liu Z. Zhou H, et al. Oncogene. 2017 Jun 8;36(23):3312-3321. doi: 10.1038/onc.2016.479. Epub 2017 Jan 9. Oncogene. 2017. PMID: 28068319 Free PMC article.
The F-box domain is critical for FBXO32-dependent KLF4 ubiquitination and degradation. Furthermore, we demonstrated that FBXO32 physically interacts with the N-terminus (1-60 aa) of KLF4 via its C-terminus (228-355 aa) and directly targets KLF4 for ubiquitination an …
The F-box domain is critical for FBXO32-dependent KLF4 ubiquitination and degradation. Furthermore, we demonstrated that FBXO32 …
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Sandri M, et al. Cell. 2004 Apr 30;117(3):399-412. doi: 10.1016/s0092-8674(04)00400-3. Cell. 2004. PMID: 15109499 Free PMC article.
Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. ...Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to comb …
Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. ...Thus, forkhead factor( …
Glyoxylic Acid, an alpha-Keto Acid Metabolite Derived from Glycine, Promotes Myogenesis in C2C12 Cells.
Norikura T, Sasaki Y, Kojima-Yuasa A, Kon A. Norikura T, et al. Nutrients. 2023 Apr 4;15(7):1763. doi: 10.3390/nu15071763. Nutrients. 2023. PMID: 37049603 Free PMC article.
In this study, we examined the effect of glyoxylic acid (GA), an alpha-keto acid metabolite derived from glycine, on myogenesis in C2C12 cells. Differentiation and mitochondrial biogenesis were used as myogenesis indicators. ...In addition, GA treatment suppressed t …
In this study, we examined the effect of glyoxylic acid (GA), an alpha-keto acid metabolite derived from glycine, on myogenesis in C2 …
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ. Stitt TN, et al. Mol Cell. 2004 May 7;14(3):395-403. doi: 10.1016/s1097-2765(04)00211-4. Mol Cell. 2004. PMID: 15125842 Free article.
Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes. ...Our study thus defines a previously uncharacterized function for Akt, which has important therapeutic relevance: Akt is not only capable of acti …
Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes. ...Our …
RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.
Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L. Xu J, et al. Int J Mol Sci. 2022 Oct 10;23(19):12036. doi: 10.3390/ijms231912036. Int J Mol Sci. 2022. PMID: 36233342 Free PMC article.
Previous studies have found that Retinoic Acid Induced 14(RAI14) is critical in tumorigenesis. However, the biological function of RAI14 for the development of melanoma is unclear. In this study, RAI14 is highly expressed in melanoma and correlated with prognosis. The expr …
Previous studies have found that Retinoic Acid Induced 14(RAI14) is critical in tumorigenesis. However, the biological function of RAI14 for …
A TGF-beta/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
Dasgupta A, Gibbard DF, Schmitt RE, Arneson-Wissink PC, Ducharme AM, Bruinsma ES, Hawse JR, Jatoi A, Doles JD. Dasgupta A, et al. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2215095120. doi: 10.1073/pnas.2215095120. Epub 2023 Aug 16. Proc Natl Acad Sci U S A. 2023. PMID: 37585460 Free PMC article.
Members of the Kruppel-like factor (KLF) family play wide-ranging and important roles in the development, maintenance, and metabolism of skeletal muscle. Within the KLF family, we identified KLF10 upregulation in a multitude of wasting contexts-including in pancreat …
Members of the Kruppel-like factor (KLF) family play wide-ranging and important roles in the development, maintenance, and metabolism …
SNP identification in FBXO32 gene and their associations with growth traits in cattle.
Wang A, Zhang Y, Li M, Lan X, Wang J, Chen H. Wang A, et al. Gene. 2013 Feb 15;515(1):181-6. doi: 10.1016/j.gene.2012.11.054. Epub 2012 Dec 8. Gene. 2013. PMID: 23232357
The F-box protein 32 (FBXO32), also known as Atrogin-1, is one of the four subunits of the ubiquitin protein ligase complex. FBXO32 has been previously shown to be involved in regulation of initiation and development of muscle mass. ...
The F-box protein 32 (FBXO32), also known as Atrogin-1, is one of the four subunits of the ubiquitin protein ligase complex. FBXO3 …
142 results