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NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome.

Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM.

Front Immunol. 2014 May 26;5:249. doi: 10.3389/fimmu.2014.00249. eCollection 2014.


A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death.

Shing JC, Choi JW, Chapman R, Schroeder MA, Sarkaria JN, Fauq A, Bram RJ.

Cancer Biol Ther. 2014 Jul;15(7):895-905. doi: 10.4161/cbt.28881. Epub 2014 Apr 22.


Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.

Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA.

Front Immunol. 2014 Feb 12;5:54. doi: 10.3389/fimmu.2014.00054. eCollection 2014.


γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE.

J Biol Chem. 2014 Feb 7;289(6):3276-87. doi: 10.1074/jbc.M113.512921. Epub 2013 Dec 18.


Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia.

Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, Andrzejewski C Jr, Fauq AH, Golde TE, Miele L, Minter LM.

J Exp Med. 2013 Jul 1;210(7):1311-29. doi: 10.1084/jem.20112615. Epub 2013 Jun 3.


Synthesis of a DOTA (Gd3+)-conjugate of proton-pump inhibitor pantoprazole for gastric wall imaging studies.

Maharvi GM, Bharucha AE, Fauq AH.

Bioorg Med Chem Lett. 2013 May 1;23(9):2808-11. doi: 10.1016/j.bmcl.2012.06.051. Epub 2012 Jun 23.


Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA.

J Med Chem. 2013 Mar 28;56(6):2246-55. doi: 10.1021/jm301280p. Epub 2013 Mar 15.


Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.

Patwardhan CA, Fauq A, Peterson LB, Miller C, Blagg BS, Chadli A.

J Biol Chem. 2013 Mar 8;288(10):7313-25. doi: 10.1074/jbc.M112.427328. Epub 2013 Jan 25.


Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site.

Beri V, Auletta JT, Maharvi GM, Wood JF, Fauq AH, Rosenberry TL.

Chem Biol Interact. 2013 Mar 25;203(1):38-43. doi: 10.1016/j.cbi.2012.09.017. Epub 2012 Oct 6.


Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.

Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.

J Neurosci. 2012 Sep 19;32(38):13125-36.


Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.

Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE.

Mol Neurodegener. 2012 Aug 14;7:39. doi: 10.1186/1750-1326-7-39.


Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin.

Bourassa P, Dubeau S, Maharvi GM, Fauq AH, Thomas TJ, Tajmir-Riahi HA.

Eur J Med Chem. 2011 Sep;46(9):4344-53. doi: 10.1016/j.ejmech.2011.07.005. Epub 2011 Jul 8.


The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.

Smith KE, Boules M, Williams K, Fauq AH, Richelson E.

Behav Brain Res. 2011 Oct 31;224(2):344-9. doi: 10.1016/j.bbr.2011.06.014. Epub 2011 Jun 21.


Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin.

Bourassa P, Dubeau S, Maharvi GM, Fauq AH, Thomas TJ, Tajmir-Riahi HA.

Biochimie. 2011 Jul;93(7):1089-101. doi: 10.1016/j.biochi.2011.03.006. Epub 2011 Mar 23.


Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids.

Maharvi GM, Edwards AO, Fauq AH.

Tetrahedron Lett. 2010 Dec 8;51(49):6426-6428.


Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ.

PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504.


Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.

Fitz NF, Cronican A, Pham T, Fogg A, Fauq AH, Chapman R, Lefterov I, Koldamova R.

J Neurosci. 2010 May 19;30(20):6862-72. doi: 10.1523/JNEUROSCI.1051-10.2010.


Differential accumulation of secreted AbetaPP metabolites in ocular fluids.

Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K.

J Alzheimers Dis. 2010;20(4):1243-53. doi: 10.3233/JAD-2010-100210.


A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen).

Fauq AH, Maharvi GM, Sinha D.

Bioorg Med Chem Lett. 2010 May 15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3.


Iothalamate quantification by tandem mass spectrometry to measure glomerular filtration rate.

Seegmiller JC, Burns BE, Fauq AH, Mukhtar N, Lieske JC, Larson TS.

Clin Chem. 2010 Apr;56(4):568-74. doi: 10.1373/clinchem.2009.133751. Epub 2010 Feb 18.

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