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Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial.

Vernieri C, Signorelli D, Galli G, Ganzinelli M, Moro M, Fabbri A, Tamborini E, Marabese M, Caiola E, Broggini M, Hollander L, Gallucci R, Vandoni G, Gavazzi C, Triulzi T, Colombo MP, Rizzo AM, Corsetto PA, Pruneri G, de Braud F, Sozzi G, Torri V, Garassino MC.

Clin Lung Cancer. 2018 Dec 19. pii: S1525-7304(18)30335-8. doi: 10.1016/j.cllc.2018.12.011. [Epub ahead of print]


Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice.

Wei S, Han R, Zhao J, Wang S, Huang M, Wang Y, Chen Y.

Nutr Metab (Lond). 2018 Nov 20;15:80. doi: 10.1186/s12986-018-0318-3. eCollection 2018.


Healthy lifestyle-based approaches for successful vascular aging.

Rossman MJ, LaRocca TJ, Martens CR, Seals DR.

J Appl Physiol (1985). 2018 Dec 1;125(6):1888-1900. doi: 10.1152/japplphysiol.00521.2018. Epub 2018 Sep 13.


To fast, or not to fast before chemotherapy, that is the question.

Caccialanza R, Cereda E, De Lorenzo F, Farina G, Pedrazzoli P; AIOM-SINPE-FAVO Working Group.

BMC Cancer. 2018 Mar 27;18(1):337. doi: 10.1186/s12885-018-4245-5. Review.


Starvation, Stress Resistance, and Cancer.

Buono R, Longo VD.

Trends Endocrinol Metab. 2018 Apr;29(4):271-280. doi: 10.1016/j.tem.2018.01.008. Epub 2018 Feb 17. Review.


Intermittent fasting and cardiovascular disease: current evidence and unresolved questions.

Tinsley GM, Horne BD.

Future Cardiol. 2018 Jan;14(1):47-54. doi: 10.2217/fca-2017-0038. Epub 2017 Dec 4. Review.


Commentary: Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

Li Volti G, Avola R, Vinciguerra M.

Front Oncol. 2017 Jun 2;7:116. doi: 10.3389/fonc.2017.00116. eCollection 2017. No abstract available.


Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells.

Lo Re O, Panebianco C, Porto S, Cervi C, Rappa F, Di Biase S, Caraglia M, Pazienza V, Vinciguerra M.

J Cell Physiol. 2018 Feb;233(2):1202-1212. doi: 10.1002/jcp.25987. Epub 2017 Jul 11.


Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.

Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD.

Cell. 2017 Feb 23;168(5):775-788.e12. doi: 10.1016/j.cell.2017.01.040.


Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD.

Sci Transl Med. 2017 Feb 15;9(377). pii: eaai8700. doi: 10.1126/scitranslmed.aai8700.


Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.

Choi IY, Lee C, Longo VD.

Mol Cell Endocrinol. 2017 Nov 5;455:4-12. doi: 10.1016/j.mce.2017.01.042. Epub 2017 Jan 28. Review.


Impact of intermittent fasting on health and disease processes.

Mattson MP, Longo VD, Harvie M.

Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. Review.


Fasting and Caloric Restriction in Cancer Prevention and Treatment.

Brandhorst S, Longo VD.

Recent Results Cancer Res. 2016;207:241-66. doi: 10.1007/978-3-319-42118-6_12. Review.


Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD.

Cancer Cell. 2016 Jul 11;30(1):136-146. doi: 10.1016/j.ccell.2016.06.005.


Fasting-induced differential stress sensitization in cancer treatment.

Di Biase S, Longo VD.

Mol Cell Oncol. 2015 Dec 10;3(3):e1117701. doi: 10.1080/23723556.2015.1117701. eCollection 2016 May.


Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.

Longo VD, Panda S.

Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. Review.


A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD.

Cell Rep. 2016 Jun 7;15(10):2136-2146. doi: 10.1016/j.celrep.2016.05.009. Epub 2016 May 26.


Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models.

D'Aronzo M, Vinciguerra M, Mazza T, Panebianco C, Saracino C, Pereira SP, Graziano P, Pazienza V.

Oncotarget. 2015 Jul 30;6(21):18545-57.


Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.

Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A.

Oncotarget. 2015 May 20;6(14):11820-32.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

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