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Co-production of farnesol and coenzyme Q(10) from metabolically engineered Rhodobacter sphaeroides.
Chen X, Jiang X, Xu M, Zhang M, Huang R, Huang J, Qi F. Chen X, et al. Microb Cell Fact. 2019 May 31;18(1):98. doi: 10.1186/s12934-019-1145-6. Microb Cell Fact. 2019. PMID: 31151455 Free PMC article.
BACKGROUND: Farnesol is an acyclic sesquiterpene alcohol present in the essential oils of various plants in nature. It has been reported to be valuable in medical applications, such as alleviation of allergic asthma, gliosis, and edema as well as anti-cancerous and anti-in …
BACKGROUND: Farnesol is an acyclic sesquiterpene alcohol present in the essential oils of various plants in nature. It has been repor …
Enhancement of NADPH availability for coproduction of coenzyme Q(10) and farnesol from Rhodobacter sphaeroides.
Xu M, Wu H, Shen P, Jiang X, Chen X, Lin J, Huang J, Qi F. Xu M, et al. J Ind Microbiol Biotechnol. 2020 Feb;47(2):263-274. doi: 10.1007/s10295-020-02261-z. Epub 2020 Jan 28. J Ind Microbiol Biotechnol. 2020. PMID: 31993848
Coenzyme Q(10) (CoQ(10))-an essential cofactor in the respiratory electron transport chain-has important pharmaceutical and healthcare applications. Farnesol (FOH)-an acyclic sesquiterpene alcohol-has garnered interest owing to its valuable clinical and medic …
Coenzyme Q(10) (CoQ(10))-an essential cofactor in the respiratory electron transport chain-has important pharmaceutical and he …
Effect of Farnesol in Trichoderma Physiology and in Fungal-Plant Interaction.
Cardoza RE, McCormick SP, Lindo L, Mayo-Prieto S, González-Cazón D, Martínez-Reyes N, Carro-Huerga G, Rodríguez-González Á, Proctor RH, Casquero PA, Gutiérrez S. Cardoza RE, et al. J Fungi (Basel). 2022 Nov 30;8(12):1266. doi: 10.3390/jof8121266. J Fungi (Basel). 2022. PMID: 36547599 Free PMC article.
Farnesol plays a central role in cell growth and differentiation, controls production of ubiquinone and ergosterol, and participates in the regulation of filamentation and biofilm formation. ...In the present article, we identified the Trichoderma harzianum gene dpp …
Farnesol plays a central role in cell growth and differentiation, controls production of ubiquinone and ergosterol, and partic …
The Biomedical Importance of the Missing Pathway for Farnesol and Geranylgeraniol Salvage.
Verdaguer IB, Crispim M, Hernández A, Katzin AM. Verdaguer IB, et al. Molecules. 2022 Dec 8;27(24):8691. doi: 10.3390/molecules27248691. Molecules. 2022. PMID: 36557825 Free PMC article. Review.
Polyprenyl transferases and synthases use polyprenyl pyrophosphates as their natural substrates; however, it is known that free polyprenols, such as farnesol (FOH), and geranylgeraniol (GGOH) can be incorporated into prenylated proteins, ubiquinone, cholesterol, and …
Polyprenyl transferases and synthases use polyprenyl pyrophosphates as their natural substrates; however, it is known that free polyprenols, …
Isoprenoid alcohols utilization by malaria parasites.
Bofill Verdaguer I, Sussmann RAC, Santiago VF, Palmisano G, Moura GC, Mesquita JT, Yamaguchi LF, Kato MJ, Katzin AM, Crispim M. Bofill Verdaguer I, et al. Front Chem. 2022 Dec 1;10:1035548. doi: 10.3389/fchem.2022.1035548. eCollection 2022. Front Chem. 2022. PMID: 36531309 Free PMC article.
Once formed, isoprene units are condensed to form longer structures such as farnesyl and geranylgeranyl pyrophosphate, which are necessary for Heme O and A formation, ubiquinone, and dolichyl phosphate biosynthesis as well as for protein isoprenylation. Even though the nat …
Once formed, isoprene units are condensed to form longer structures such as farnesyl and geranylgeranyl pyrophosphate, which are necessary f …
Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers.
Turunen M, Sindelar P, Dallner G. Turunen M, et al. Biofactors. 1999;9(2-4):131-9. doi: 10.1002/biof.5520090207. Biofactors. 1999. PMID: 10416024
A large number of chemical compounds have been identified which cause peroxisomal proliferation and induce a number of enzymes, mainly those participating in lipid metabolism. Administration of these drugs/chemicals to rats increased coenzyme Q levels in the blood a …
A large number of chemical compounds have been identified which cause peroxisomal proliferation and induce a number of enzymes, mainly those …
Cardioprotection by farnesol: role of the mevalonate pathway.
Szűcs G, Murlasits Z, Török S, Kocsis GF, Pálóczi J, Görbe A, Csont T, Csonka C, Ferdinandy P. Szűcs G, et al. Cardiovasc Drugs Ther. 2013 Aug;27(4):269-77. doi: 10.1007/s10557-013-6460-2. Cardiovasc Drugs Ther. 2013. PMID: 23673412
We examined whether farnesol treatment protects the ischemic heart. METHODS: Male Wistar rats were treated orally with 0.2, 1, 5, and 50 mg/kg/day farnesol/vehicle for 12 days, respectively. ...CONCLUSIONS: This is the first demonstration that oral farnesol t …
We examined whether farnesol treatment protects the ischemic heart. METHODS: Male Wistar rats were treated orally with 0.2, 1, 5, and …
Farnesol as an antifungal agent: comparisons among MTLa and MTLalpha haploid and diploid Candida albicans and Saccharomyces cerevisiae.
Boone CHT, Parker KA, Gutzmann DJ, Atkin AL, Nickerson KW. Boone CHT, et al. Front Physiol. 2023 Nov 20;14:1207567. doi: 10.3389/fphys.2023.1207567. eCollection 2023. Front Physiol. 2023. PMID: 38054042 Free PMC article.
Conclusion: We propose that the observed MTL dependence of farnesol is based on differentially regulated mechanisms of entry and efflux which determine the actual cellular concentration of farnesol. The mechanisms by which pathogens such as C. albicans tolerate the …
Conclusion: We propose that the observed MTL dependence of farnesol is based on differentially regulated mechanisms of entry and effl …
Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis.
Bentinger M, Tekle M, Brismar K, Chojnacki T, Swiezewska E, Dallner G. Bentinger M, et al. J Biol Chem. 2008 May 23;283(21):14645-53. doi: 10.1074/jbc.M710202200. Epub 2008 Mar 18. J Biol Chem. 2008. PMID: 18353784 Free article.
In our search for compounds that up-regulate the biosynthesis of coenzyme Q (CoQ), we discovered that irradiation of CoQ with ultraviolet light results in the formation of a number of compounds that influence the synthesis of mevalonate pathway lipids by HepG2 cells …
In our search for compounds that up-regulate the biosynthesis of coenzyme Q (CoQ), we discovered that irradiation of CoQ with …
Longer Ubiquinone Side Chains Contribute to Enhanced Farnesol Resistance in Yeasts.
Pathirana RU, Boone C, Nickerson KW. Pathirana RU, et al. Microorganisms. 2020 Oct 23;8(11):1641. doi: 10.3390/microorganisms8111641. Microorganisms. 2020. PMID: 33114039 Free PMC article.
Thus, we were intrigued by the presence of UQ9 isoprenologue in farnesol-producing Candida species while other members of this genera harbor UQ7 as their major electron carrier. ...The resistance provided by UQ9 is specific for farnesol in that it does not increase …
Thus, we were intrigued by the presence of UQ9 isoprenologue in farnesol-producing Candida species while other members of this genera …
33 results