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Design and testing of a cyclic stretch and flexure bioreactor for evaluating engineered heart valve tissues based on poly(glycerol sebacate) scaffolds.

Masoumi N, Howell MC, Johnson KL, Niesslein MJ, Gerber G, Engelmayr GC Jr.

Proc Inst Mech Eng H. 2014 Jun;228(6):576-586. Epub 2014 Jun 4.


Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo.

Juhas M, Engelmayr GC Jr, Fontanella AN, Palmer GM, Bursac N.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5508-13. doi: 10.1073/pnas.1402723111. Epub 2014 Mar 31.


Valvular interstitial cell seeded poly(glycerol sebacate) scaffolds: toward a biomimetic in vitro model for heart valve tissue engineering.

Masoumi N, Johnson KL, Howell MC, Engelmayr GC Jr.

Acta Biomater. 2013 Apr;9(4):5974-88. doi: 10.1016/j.actbio.2013.01.001. Epub 2013 Jan 5.


Three-dimensional elastomeric scaffolds designed with cardiac-mimetic structural and mechanical features.

Neal RA, Jean A, Park H, Wu PB, Hsiao J, Engelmayr GC Jr, Langer R, Freed LE.

Tissue Eng Part A. 2013 Mar;19(5-6):793-807. doi: 10.1089/ten.tea.2012.0330. Epub 2012 Nov 28.


Anisotropic collagen fibrillogenesis within microfabricated scaffolds: implications for biomimetic tissue engineering.

Jean A, Engelmayr GC Jr.

Adv Healthc Mater. 2012 Jan 11;1(1):112-6. doi: 10.1002/adhm.201100017. Epub 2011 Dec 15.


Laser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering.

Masoumi N, Jean A, Zugates JT, Johnson KL, Engelmayr GC Jr.

J Biomed Mater Res A. 2013 Jan;101(1):104-14. doi: 10.1002/jbm.a.34305. Epub 2012 Jul 24.


The significance of pore microarchitecture in a multi-layered elastomeric scaffold for contractile cardiac muscle constructs.

Park H, Larson BL, Guillemette MD, Jain SR, Hua C, Engelmayr GC Jr, Freed LE.

Biomaterials. 2011 Mar;32(7):1856-64. doi: 10.1016/j.biomaterials.2010.11.032. Epub 2010 Dec 8.


Advanced material strategies for tissue engineering scaffolds.

Freed LE, Engelmayr GC Jr, Borenstein JT, Moutos FT, Guilak F.

Adv Mater. 2009 Sep 4;21(32-33):3410-8. doi: 10.1002/adma.200900303. No abstract available.


Finite element analysis of an accordion-like honeycomb scaffold for cardiac tissue engineering.

Jean A, Engelmayr GC Jr.

J Biomech. 2010 Nov 16;43(15):3035-43. doi: 10.1016/j.jbiomech.2010.06.032. Epub 2010 Jul 31.


Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device.

Tobias IS, Lee H, Engelmayr GC Jr, Macaya D, Bettinger CJ, Cima MJ.

J Control Release. 2010 Sep 15;146(3):356-62. doi: 10.1016/j.jconrel.2010.05.036. Epub 2010 Jun 4.


In vivo monitoring of function of autologous engineered pulmonary valve.

Gottlieb D, Kunal T, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC Jr, Melero-Martin JM, Sacks MS, Mayer JE Jr.

J Thorac Cardiovasc Surg. 2010 Mar;139(3):723-31. doi: 10.1016/j.jtcvs.2009.11.006.


The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.

Ramaswamy S, Gottlieb D, Engelmayr GC Jr, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE Jr, Sacks MS.

Biomaterials. 2010 Feb;31(6):1114-25. doi: 10.1016/j.biomaterials.2009.10.019. Epub 2009 Nov 26.


Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.

Sales VL, Mettler BA, Engelmayr GC Jr, Aikawa E, Bischoff J, Martin DP, Exarhopoulos A, Moses MA, Schoen FJ, Sacks MS, Mayer JE Jr.

Tissue Eng Part A. 2010 Jan;16(1):257-67. doi: 10.1089/ten.TEA.2009.0424.


Encapsulated pheochromocytoma cells secrete potent noncatecholamine factors.

Mobine HR, Engelmayr GC Jr, Moussazadeh N, Anwar TR, Freed LE, Edelman ER.

Tissue Eng Part A. 2009 Jul;15(7):1719-28. doi: 10.1089/ten.tea.2008.0412.


Accordion-like honeycombs for tissue engineering of cardiac anisotropy.

Engelmayr GC Jr, Cheng M, Bettinger CJ, Borenstein JT, Langer R, Freed LE.

Nat Mater. 2008 Dec;7(12):1003-10. doi: 10.1038/nmat2316. Epub 2008 Nov 2.


Insulin-like growth factor-I and slow, bi-directional perfusion enhance the formation of tissue-engineered cardiac grafts.

Cheng M, Moretti M, Engelmayr GC, Freed LE.

Tissue Eng Part A. 2009 Mar;15(3):645-53. doi: 10.1089/ten.tea.2008.0077.


Co-culture induces alignment in engineered cardiac constructs via MMP-2 expression.

Nichol JW, Engelmayr GC Jr, Cheng M, Freed LE.

Biochem Biophys Res Commun. 2008 Aug 29;373(3):360-5. doi: 10.1016/j.bbrc.2008.06.019. Epub 2008 Jun 16.


A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology.

Engelmayr GC Jr, Soletti L, Vigmostad SC, Budilarto SG, Federspiel WJ, Chandran KB, Vorp DA, Sacks MS.

Ann Biomed Eng. 2008 May;36(5):700-12. doi: 10.1007/s10439-008-9447-6. Epub 2008 Feb 6.


Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast.

Merryman WD, Lukoff HD, Long RA, Engelmayr GC Jr, Hopkins RA, Sacks MS.

Cardiovasc Pathol. 2007 Sep-Oct;16(5):268-76. Epub 2007 May 17.


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