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Items: 6


Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.

Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD.

ChemMedChem. 2019 Mar 5;14(5):545-560. doi: 10.1002/cmdc.201800725. Epub 2019 Feb 5.


Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors.

Ghosh AK, Cárdenas EL, Brindisi M.

Tetrahedron Lett. 2017 Oct 25;58(43):4062-4065. doi: 10.1016/j.tetlet.2017.09.025. Epub 2017 Sep 14.


Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.

Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2432-2438. doi: 10.1016/j.bmcl.2017.04.011. Epub 2017 Apr 8.


Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.

Ghosh AK, Reddy BS, Yen YC, Cardenas E, Rao KV, Downs D, Huang X, Tang J, Mesecar AD.

Chem Sci. 2016 May 1;7:3117-3122. Epub 2016 Feb 4.


Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene.

Ghosh AK, Lv K, Ma N, Cárdenas EL, Effenberger KA, Jurica MS.

Org Biomol Chem. 2016 Jun 21;14(23):5263-71. doi: 10.1039/c6ob00725b. Epub 2016 May 18.


Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma.

Schott JT, Mordaunt CE, Vargas AJ, Leon MA, Chen KH, Singh M, Satoh M, Cardenas EL, Maitra S, Patel NV, de Lijser HJ.

Chem Pharm Bull (Tokyo). 2013;61(2):229-36. Epub 2012 Nov 27.

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