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Items: 1 to 20 of 32


Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.


Networks of Dynamic Allostery Regulate Enzyme Function.

Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ.

Structure. 2017 Feb 7;25(2):276-286. doi: 10.1016/j.str.2016.12.003. Epub 2017 Jan 12.


CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming.

Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ.

Oncotarget. 2017 Jan 24;8(4):6742-6762. doi: 10.18632/oncotarget.14272.


Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro.

Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ.

Protein Sci. 2017 Mar;26(3):600-610. doi: 10.1002/pro.3110. Epub 2017 Feb 23.


Dynamical network of residue-residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation.

Doshi U, Holliday MJ, Eisenmesser EZ, Hamelberg D.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4735-40. doi: 10.1073/pnas.1523573113. Epub 2016 Apr 11.


Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems.

Holliday MJ, Armstrong GS, Eisenmesser EZ.

Biochemistry. 2015 Sep 29;54(38):5815-27. doi: 10.1021/acs.biochem.5b00746. Epub 2015 Sep 11.


Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures.

Holliday MJ, Camilloni C, Armstrong GS, Isern NG, Zhang F, Vendruscolo M, Eisenmesser EZ.

Biochemistry. 2015 May 26;54(20):3207-17. doi: 10.1021/acs.biochem.5b00263. Epub 2015 May 14.


Inherent dynamics within the Crimean-Congo Hemorrhagic fever virus protease are localized to the same region as substrate interactions.

Eisenmesser EZ, Capodagli GC, Armstrong GS, Holliday MJ, Isern NG, Zhang F, Pegan SD.

Protein Sci. 2015 May;24(5):651-60. doi: 10.1002/pro.2637. Epub 2015 Jan 28.


Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.

Camilloni C, Sahakyan AB, Holliday MJ, Isern NG, Zhang F, Eisenmesser EZ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10203-8. doi: 10.1073/pnas.1404220111. Epub 2014 Jun 30.


Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R.

J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22.


Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.

Chi YC, Armstrong GS, Jones DN, Eisenmesser EZ, Liu CW.

J Biol Chem. 2014 May 30;289(22):15474-81. doi: 10.1074/jbc.M113.544049. Epub 2014 Apr 17.


The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.

Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ.

Protein Sci. 2014 Apr;23(4):464-80. doi: 10.1002/pro.2430. Epub 2014 Feb 12.


Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-β1 and EMMPRIN.

Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ.

PLoS One. 2013 Aug 1;8(8):e71225. doi: 10.1371/journal.pone.0071225. Print 2013.


1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A.

Holliday MJ, Zhang F, Isern NG, Armstrong GS, Eisenmesser EZ.

Biomol NMR Assign. 2014 Apr;8(1):23-7. doi: 10.1007/s12104-012-9445-3. Epub 2012 Nov 9.


Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B.

Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E.

Cancer Cell Int. 2012 Jul 4;12(1):19. doi: 10.1186/1475-2867-12-19.


The retinal specific CD147 Ig0 domain: from molecular structure to biological activity.

Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ.

J Mol Biol. 2011 Aug 5;411(1):68-82. doi: 10.1016/j.jmb.2011.04.060. Epub 2011 May 19.


Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR.

Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D.

J Mol Biol. 2010 Nov 12;403(5):723-38. doi: 10.1016/j.jmb.2010.08.001. Epub 2010 Aug 12.


Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S.

PLoS Biol. 2010 Jul 27;8(7):e1000439. doi: 10.1371/journal.pbio.1000439.


Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair.

Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM.

J Biol Chem. 2010 Aug 27;285(35):27251-8. doi: 10.1074/jbc.M110.106617. Epub 2010 Jun 17.


Transient non-native hydrogen bonds promote activation of a signaling protein.

Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D.

Cell. 2009 Dec 11;139(6):1109-18. doi: 10.1016/j.cell.2009.11.022.

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