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Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.

Yan R, Zhang J, Park HJ, Park ES, Oh S, Zheng H, Junn E, Voronkov M, Stock JB, Mouradian MM.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12053-E12062. doi: 10.1073/pnas.1813365115. Epub 2018 Dec 3.


Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, PĂ©rez E, Stock M, Stock JB, Arancio O, Nicholls RE.

PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017.


Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.

Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K.

Neurobiol Aging. 2014 Dec;35(12):2701-2712. doi: 10.1016/j.neurobiolaging.2014.06.012. Epub 2014 Jun 17.


Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.

Lee KW, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM.

Neurotherapeutics. 2013 Jan;10(1):143-53. doi: 10.1007/s13311-012-0165-2.

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