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Items: 1 to 20 of 23


Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome.

Rajshekar S, Yao J, Arnold PK, Payne SG, Zhang Y, Bowman TV, Schmitz RJ, Edwards JR, Goll M.

Elife. 2018 Nov 28;7. pii: e39658. doi: 10.7554/eLife.39658.


A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis.

Powell E, Shao J, Picon HM, Bristow C, Ge Z, Peoples M, Robinson F, Jeter-Jones SL, Schlosberg C, Grzeskowiak CL, Yang F, Wu Y, Wistuba I, Moulder SL, Symmans WF, Scott KL, Edwards JR, Liang H, Heffernan TP, Piwnica-Worms H.

NPJ Breast Cancer. 2018 Apr 30;4:9. doi: 10.1038/s41523-018-0062-x. eCollection 2018.


DNA methylation and DNA methyltransferases.

Edwards JR, Yarychkivska O, Boulard M, Bestor TH.

Epigenetics Chromatin. 2017 May 8;10:23. doi: 10.1186/s13072-017-0130-8. eCollection 2017. Review.


Modeling complex patterns of differential DNA methylation that associate with gene expression changes.

Schlosberg CE, VanderKraats ND, Edwards JR.

Nucleic Acids Res. 2017 May 19;45(9):5100-5111. doi: 10.1093/nar/gkx078.


Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer.

Hiken JF, McDonald JI, Decker KF, Sanchez C, Hoog J, VanderKraats ND, Jung KL, Akinhanmi M, Rois LE, Ellis MJ, Edwards JR.

Oncogene. 2017 Apr 20;36(16):2319-2327. doi: 10.1038/onc.2016.397. Epub 2016 Nov 21.


Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K, Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SA.

Nat Commun. 2016 Jun 8;7:11762. doi: 10.1038/ncomms11762.


Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10.

Boulard M, Edwards JR, Bestor TH.

Epigenetics Chromatin. 2016 May 31;9:22. doi: 10.1186/s13072-016-0069-1. eCollection 2016.


Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.

McDonald JI, Celik H, Rois LE, Fishberger G, Fowler T, Rees R, Kramer A, Martens A, Edwards JR, Challen GA.

Biol Open. 2016 Jun 15;5(6):866-74. doi: 10.1242/bio.019067.


p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer.

Powell E, Shao J, Yuan Y, Chen HC, Cai S, Echeverria GV, Mistry N, Decker KF, Schlosberg C, Do KA, Edwards JR, Liang H, Piwnica-Worms D, Piwnica-Worms H.

Breast Cancer Res. 2016 Jan 27;18(1):13. doi: 10.1186/s13058-016-0673-9.


Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis.

O'Donnell AH, Edwards JR, Rollins RA, Vander Kraats ND, Su T, Hibshoosh HH, Bestor TH.

J Cancer Ther. 2014 Dec 1;5(14):1311-1324.


Impact of dialect use on a basic component of learning to read.

Brown MC, Sibley DE, Washington JA, Rogers TT, Edwards JR, MacDonald MC, Seidenberg MS.

Front Psychol. 2015 Mar 24;6:196. doi: 10.3389/fpsyg.2015.00196. eCollection 2015.


FBXL10 protects Polycomb-bound genes from hypermethylation.

Boulard M, Edwards JR, Bestor TH.

Nat Genet. 2015 May;47(5):479-85. doi: 10.1038/ng.3272. Epub 2015 Apr 6.


Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development.

Bestor TH, Edwards JR, Boulard M.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2117. doi: 10.1073/pnas.1504199112. Epub 2015 Apr 6. No abstract available.


Notes on the role of dynamic DNA methylation in mammalian development.

Bestor TH, Edwards JR, Boulard M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6796-9. doi: 10.1073/pnas.1415301111. Epub 2014 Nov 3. Review.


DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML.

Lund K, Cole JJ, VanderKraats ND, McBryan T, Pchelintsev NA, Clark W, Copland M, Edwards JR, Adams PD.

Genome Biol. 2014 Aug 30;15(8):406. doi: 10.1186/s13059-014-0406-2.


Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.

Matkovich SJ, Edwards JR, Grossenheider TC, de Guzman Strong C, Dorn GW 2nd.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12264-9. doi: 10.1073/pnas.1410622111. Epub 2014 Jul 28.


Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.

Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ.

Cell Rep. 2013 Sep 26;4(6):1116-30. doi: 10.1016/j.celrep.2013.08.022. Epub 2013 Sep 19.


Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes.

Vanderkraats ND, Hiken JF, Decker KF, Edwards JR.

Nucleic Acids Res. 2013 Aug;41(14):6816-27. doi: 10.1093/nar/gkt482. Epub 2013 Jun 7.


DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV.

Tian F, Zhan F, VanderKraats ND, Hiken JF, Edwards JR, Zhang H, Zhao K, Song J.

Epigenetics. 2013 Apr;8(4):431-44. doi: 10.4161/epi.24361. Epub 2013 Mar 28.

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