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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 5
1952 5
1953 18
1954 27
1955 42
1956 71
1957 90
1958 94
1959 92
1960 78
1961 161
1962 237
1963 235
1964 461
1965 426
1966 382
1967 513
1968 559
1969 667
1970 654
1971 818
1972 775
1973 772
1974 884
1975 746
1976 559
1977 497
1978 401
1979 448
1980 469
1981 438
1982 438
1983 432
1984 482
1985 536
1986 430
1987 353
1988 342
1989 437
1990 468
1991 465
1992 444
1993 423
1994 445
1995 401
1996 399
1997 393
1998 361
1999 365
2000 390
2001 405
2002 401
2003 420
2004 419
2005 450
2006 424
2007 459
2008 466
2009 438
2010 394
2011 430
2012 465
2013 469
2014 435
2015 371
2016 411
2017 457
2018 423
2019 449
2020 429
2021 333
2022 454
2023 379
2024 117

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28,200 results

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Page 1
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning.
Bradberry S, Vale A. Bradberry S, et al. Clin Toxicol (Phila). 2009 Nov;47(9):841-58. doi: 10.3109/15563650903321064. Clin Toxicol (Phila). 2009. PMID: 19852620 Review.
INTRODUCTION: This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, blood and tissue lead concentrations, resolution of features and survival) of sodium calcium edetate (edetate calcium …
INTRODUCTION: This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, bl …
Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients.
Lamas GA, Issa OM. Lamas GA, et al. Curr Cardiol Rep. 2016 Feb;18(2):20. doi: 10.1007/s11886-015-0690-9. Curr Cardiol Rep. 2016. PMID: 26797807 Review.
This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was …
This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular …
Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation.
Kumar N, Soni S, Jaimini A, Ahmad FJ, Bhatnagar A, Mittal G. Kumar N, et al. Int J Pharm. 2011 Sep 15;416(1):376-83. doi: 10.1016/j.ijpharm.2011.06.038. Epub 2011 Jun 28. Int J Pharm. 2011. PMID: 21740960 Clinical Trial.
Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and assess its in vitro and in vivo deposition using pharmacoscintigraphy techniques. ...
Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and as …
A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults.
Sakthithasan K, Lévy P, Poupon J, Garnier R. Sakthithasan K, et al. Clin Toxicol (Phila). 2018 Nov;56(11):1143-1149. doi: 10.1080/15563650.2018.1478424. Epub 2018 Jun 11. Clin Toxicol (Phila). 2018. PMID: 29889577 Free article.
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa(2)EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. ...
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa(2)EDTA) and dimercaptosuccinic …
Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer.
Yarbrough M, Hodge T, Menard D, Jerome R, Ryczek J, Moore D, Baldus P, Warne N, Ohtake S. Yarbrough M, et al. J Pharm Sci. 2019 Apr;108(4):1631-1635. doi: 10.1016/j.xphs.2018.11.031. Epub 2018 Nov 29. J Pharm Sci. 2019. PMID: 30502482
The results indicated that a different source material exhibited different rates of mAb oxidation and PS80 loss and that in all evaluated materials, the addition of edetate disodium to the formulation mitigated both observed issues. The mAb was assessed for the pres …
The results indicated that a different source material exhibited different rates of mAb oxidation and PS80 loss and that in all evaluated ma …
Calcium disodium edetate enhances type A monoamine oxidase activity in monkey brain.
Egashira T, Sakai K, Sakurai M, Takayama F. Egashira T, et al. Biol Trace Elem Res. 2003 Sep;94(3):203-11. doi: 10.1385/BTER:94:3:203. Biol Trace Elem Res. 2003. PMID: 12972688
The effects of metal chelators on monoamine oxidase (MAO) isozymes, MAO-A and MAO-B, in monkey brain mitochondria were investigated in vitro. MAO-A activity increased to about 40% with 0.1 microM calcium disodium edetate (CaNa2EDTA) using serotonin as a subst …
The effects of metal chelators on monoamine oxidase (MAO) isozymes, MAO-A and MAO-B, in monkey brain mitochondria were investigated in vitro …
Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT).
Escolar E, Ujueta F, Kim H, Mark DB, Boineau R, Nahin RL, Goertz C, Lee KL, Anstrom KJ, Lamas GA. Escolar E, et al. J Diabetes Complications. 2020 Aug;34(8):107616. doi: 10.1016/j.jdiacomp.2020.107616. Epub 2020 May 7. J Diabetes Complications. 2020. PMID: 32446881 Free PMC article. Clinical Trial.
BACKGROUND: The NIH-funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stable patients age 50 who were 6 months post myocardial infarction to 40 infusions of an edetate disodium-based regimen or placebo. In 633 patients with diabetes, edetate …
BACKGROUND: The NIH-funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stable patients age 50 who were 6 months post myocardial …
Metal chelators and neurotoxicity: lead, mercury, and arsenic.
Bjørklund G, Mutter J, Aaseth J. Bjørklund G, et al. Arch Toxicol. 2017 Dec;91(12):3787-3797. doi: 10.1007/s00204-017-2100-0. Epub 2017 Oct 24. Arch Toxicol. 2017. PMID: 29063135 Review.
This article reviews the clinical use of the metal chelators sodium 2,3-dimercapto-1-propanesulfonate (DMPS), meso-2,3-dimercaptosuccinic acid (DMSA), and calcium disodium edetate (CaEDTA, calcium EDTA) in overexposure and poisonings with salts …
This article reviews the clinical use of the metal chelators sodium 2,3-dimercapto-1-propanesulfonate (DMPS), meso-2,3-dimercaptosuccinic …
P1 Buffer.
[No authors listed] [No authors listed] Cold Spring Harb Protoc. 2017 Jul 5;2017(7). doi: 10.1101/pdb.rec096636. Cold Spring Harb Protoc. 2017. PMID: 28679715 No abstract available.
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