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Best matches for drug AND (discovery OR development):

Fluorination methods for drug discovery and development. Richardson P et al. Expert Opin Drug Discov. (2016)

Direct-to-Consumer Genetic Testing and Orphan Drug Development. Mason M et al. Genet Test Mol Biomarkers. (2017)

Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry. Blundell TL et al. IUCrJ. (2017)

Search results

Items: 1 to 20 of 718572

1.

Critical studies of harm reduction: Overdose response in uncertain political times.

Watson TM, Kolla G, van der Meulen E, Dodd Z.

Int J Drug Policy. 2019 Dec 11;76:102615. doi: 10.1016/j.drugpo.2019.102615. [Epub ahead of print]

PMID:
31837567
2.

Preclinical development of a novel BCR-ABL T315I inhibitor against chronic myeloid leukemia.

Gupta P, Zhang GN, Barbuti AM, Xin Z, Karadkhelkar N, Zhou J, Ding K, Pan J, Yoganathan S, Yang DH, Chen ZS.

Cancer Lett. 2019 Dec 11. pii: S0304-3835(19)30606-8. doi: 10.1016/j.canlet.2019.11.040. [Epub ahead of print]

PMID:
31837444
3.

Development and Analytical Validation of a DNA Dual-Strand Approach for the FDA-Approved Next-Generation Sequencing-Based Praxis Extended RAS Panel for Metastatic Colorectal Cancer Samples.

Udar N, Iyer A, Porter M, Haigis R, Smith S, Dhillon S, Meier K, Ward D, Lu J, Wenz P, Buchner L, Dunn T, Wise A, Mueller A, Gutekunst K.

J Mol Diagn. 2019 Dec 11. pii: S1525-1578(19)30439-8. doi: 10.1016/j.jmoldx.2019.09.009. [Epub ahead of print]

PMID:
31837434
4.

Preparation of a Ribosomally Synthesized Fungal Peptide Toxin Precursor and its in-vitro Cyclization.

Pathiraja D, Byun J, Lee S, Choi IG.

J Biotechnol. 2019 Dec 11. pii: S0168-1656(19)30932-0. doi: 10.1016/j.jbiotec.2019.12.004. [Epub ahead of print]

PMID:
31837370
5.

Non-transdermal microneedles for advanced drug delivery.

Lee K, Goudie MJ, Tebon P, Sun W, Luo Z, Lee J, Zhang S, Fetah K, Kim HJ, Xue Y, Darabi MA, Ahadian S, Sarikhani E, Ryu W, Gu Z, Weiss PS, Dokmeci MR, Ashammakhi N, Khademhosseini A.

Adv Drug Deliv Rev. 2019 Dec 11. pii: S0169-409X(19)30240-6. doi: 10.1016/j.addr.2019.11.010. [Epub ahead of print] Review.

PMID:
31837356
6.

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages.

Isaksson R, Casselbrant A, Elebring E, Hallberg M, Larhed M, Fändriks L.

Eur J Pharmacol. 2019 Dec 11:172855. doi: 10.1016/j.ejphar.2019.172855. [Epub ahead of print]

PMID:
31837306
7.

The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis.

Khotib J, Utami NW, Gani MA, Ardianto C.

J Basic Clin Physiol Pharmacol. 2019 Dec 14. pii: /j/jbcpp.ahead-of-print/jbcpp-2019-0331/jbcpp-2019-0331.xml. doi: 10.1515/jbcpp-2019-0331. [Epub ahead of print]

PMID:
31837258
8.

Gold nanoshell-mediated photothermal therapy for acne vulgaris.

Park KY, Han HS, Hong JY, Seo SJ, Lee SJ.

Dermatol Ther. 2019 Dec 14:e13189. doi: 10.1111/dth.13189. [Epub ahead of print]

PMID:
31837243
9.

Mouse T-complex protein 11 is important for progressive motility in sperm.

Castaneda JM, Miyata H, Archambeault DR, Satouh Y, Yu Z, Ikawa M, Matzuk MM.

Biol Reprod. 2019 Dec 14. pii: ioz226. doi: 10.1093/biolre/ioz226. [Epub ahead of print]

PMID:
31837139
10.

Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high fat diet.

Mochida T, Take K, Maki T, Nakakariya M, Adachi R, Sato K, Kitazaki T, Takekawa S.

FEBS Open Bio. 2019 Dec 13. doi: 10.1002/2211-5463.12778. [Epub ahead of print]

PMID:
31837122
11.

Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines.

Krammer F, Weir JP, Engelhardt O, Katz JM, Cox RJ.

Influenza Other Respir Viruses. 2019 Dec 13. doi: 10.1111/irv.12706. [Epub ahead of print]

PMID:
31837101
12.

Efficacy of SM-1 in a transient insomnia model.

Dahl T, Chen LB, Zammit G, Ahmad M, Roth T.

Hum Psychopharmacol. 2019 Nov;34(6):e2713. doi: 10.1002/hup.2713.

PMID:
31837050
13.

Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1).

Bugda Gwilt K, González DP, Olliffe N, Oller H, Hoffing R, Puzan M, El Aidy S, Miller GM.

Cell Mol Neurobiol. 2019 Dec 13. doi: 10.1007/s10571-019-00772-7. [Epub ahead of print] Review.

PMID:
31836967
14.

β-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.

Crocker CL, Baumgarner BL, Kinsey ST.

J Muscle Res Cell Motil. 2019 Dec 13. doi: 10.1007/s10974-019-09568-0. [Epub ahead of print]

PMID:
31836952
15.

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead.

Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M.

Nat Rev Drug Discov. 2019 Dec 13. doi: 10.1038/s41573-019-0049-9. [Epub ahead of print] Review.

PMID:
31836861
16.

The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration.

Bechynska K, Daskova N, Vrzackova N, Harant K, Heczková M, Podzimkova K, Bratova M, Dankova H, Berkova Z, Kosek V, Zelenka J, Hajslova J, Sedlacek R, Suttnar J, Hlavackova A, Bartonova L, Cahova M.

Sci Rep. 2019 Dec 13;9(1):19097. doi: 10.1038/s41598-019-54225-8.

PMID:
31836843
17.

Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease.

Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Panwar A, Lucas SJ, Pandey A, Kang SG.

Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5.

PMID:
31836806
18.

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.

Lima BHF, Marques PE, Gomides LF, Mattos MS, Kraemer L, Queiroz-Junior CM, Lennon M, Hirsch E, Russo RC, Menezes GB, Hessel EM, Amour A, Teixeira MM.

Sci Rep. 2019 Dec 13;9(1):19085. doi: 10.1038/s41598-019-55504-0.

PMID:
31836766
19.

Evidence for an effect of receptor density on ligand occupancy and agonist EC50.

Jarvis GE, Thompson AJ.

Sci Rep. 2019 Dec 13;9(1):19111. doi: 10.1038/s41598-019-55361-x.

PMID:
31836743
20.

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S.

Sci Rep. 2019 Dec 13;9(1):19130. doi: 10.1038/s41598-019-55240-5.

PMID:
31836723

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