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Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in Salmonella enterica.

Borchert AJ, Walejko JM, Guennec AL, Ernst DC, Edison AS, Downs DM.

Metabolites. 2019 Dec 24;10(1). pii: E12. doi: 10.3390/metabo10010012.


Balancing cost and benefit: How E. coli cleverly averts disulfide stress caused by cystine.

Downs DM.

Mol Microbiol. 2020 Jan;113(1):1-3. doi: 10.1111/mmi.14422. Epub 2019 Nov 28.


Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli.

Ito T, Hori R, Hemmi H, Downs DM, Yoshimura T.

Mol Microbiol. 2020 Jan;113(1):270-284. doi: 10.1111/mmi.14415. Epub 2019 Nov 24.


Cj1388 Is a RidA Homolog and Is Required for Flagella Biosynthesis and/or Function in Campylobacter jejuni.

Irons J, Sacher JC, Szymanski CM, Downs DM.

Front Microbiol. 2019 Sep 6;10:2058. doi: 10.3389/fmicb.2019.02058. eCollection 2019.


Reactive Enamines and Imines In Vivo: Lessons from the RidA Paradigm.

Borchert AJ, Ernst DC, Downs DM.

Trends Biochem Sci. 2019 Oct;44(10):849-860. doi: 10.1016/j.tibs.2019.04.011. Epub 2019 May 15. Review.


Conserved Pyridoxal 5'-Phosphate-Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5'-Phosphate in Escherichia coli.

Ito T, Yamamoto K, Hori R, Yamauchi A, Downs DM, Hemmi H, Yoshimura T.

Appl Environ Microbiol. 2019 May 16;85(11). pii: e00430-19. doi: 10.1128/AEM.00430-19. Print 2019 Jun 1.


SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae.

Paxhia MD, Downs DM.

G3 (Bethesda). 2019 Feb 7;9(2):335-344. doi: 10.1534/g3.118.200831.


Analyses of variants of the Ser/Thr dehydratase IlvA provide insight into 2-aminoacrylate metabolism in Salmonella enterica.

Borchert AJ, Downs DM.

J Biol Chem. 2018 Dec 14;293(50):19240-19249. doi: 10.1074/jbc.RA118.005626. Epub 2018 Oct 16.


PA5339, a RidA Homolog, Is Required for Full Growth in Pseudomonas aeruginosa.

Irons J, Hodge-Hanson KM, Downs DM.

J Bacteriol. 2018 Oct 23;200(22). pii: e00434-18. doi: 10.1128/JB.00434-18. Print 2018 Nov 15.


Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways.

Ernst DC, Borchert AJ, Downs DM.

PLoS One. 2018 May 23;13(5):e0197703. doi: 10.1371/journal.pone.0197703. eCollection 2018.


The three-legged stool of understanding metabolism: integrating metabolomics with biochemical genetics and computational modeling.

Downs DM, Bazurto JV, Gupta A, Fonseca LL, Voit EO.

AIMS Microbiol. 2018 Apr 8;4(2):289-303. doi: 10.3934/microbiol.2018.2.289. eCollection 2018.


Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae.

Ernst DC, Downs DM.

mBio. 2018 Feb 27;9(1). pii: e00084-18. doi: 10.1128/mBio.00084-18.


Increased Activity of Cystathionine β-Lyase Suppresses 2-Aminoacrylate Stress in Salmonella enterica.

Ernst DC, Christopherson MR, Downs DM.

J Bacteriol. 2018 Apr 9;200(9). pii: e00040-18. doi: 10.1128/JB.00040-18. Print 2018 May 1.


Expression of Pyridoxal 5'-Phosphate-Independent Racemases Can Reduce 2-Aminoacrylate Stress in Salmonella enterica.

Hodge-Hanson KM, Zoino A, Downs DM.

J Bacteriol. 2018 Apr 9;200(9). pii: e00751-17. doi: 10.1128/JB.00751-17. Print 2018 May 1.


Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica.

Bazurto JV, Dearth SP, Tague ED, Campagna SR, Downs DM.

Microb Cell. 2017 Nov 22;5(2):74-87. doi: 10.15698/mic2018.02.613.


Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica.

Borchert AJ, Downs DM.

Sci Rep. 2017 Oct 11;7(1):12971. doi: 10.1038/s41598-017-13030-x.


Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro.

Hodge-Hanson KM, Downs DM.

PLoS One. 2017 Sep 28;12(9):e0185544. doi: 10.1371/journal.pone.0185544. eCollection 2017.


The Response to 2-Aminoacrylate Differs in Escherichia coli and Salmonella enterica, despite Shared Metabolic Components.

Borchert AJ, Downs DM.

J Bacteriol. 2017 Jun 27;199(14). pii: e00140-17. doi: 10.1128/JB.00140-17. Print 2017 Jul 15.


Metabolic network structure and function in bacteria goes beyond conserved enzyme components.

Bazurto JV, Downs DM.

Microb Cell. 2016 Apr 14;3(6):260-262. doi: 10.15698/mic2016.06.509.


Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.

ElRamlawy KG, Fujimura T, Baba K, Kim JW, Kawamoto C, Isobe T, Abe T, Hodge-Hanson K, Downs DM, Refaat IH, Beshr Al-Azhary D, Aki T, Asaoku Y, Hayashi T, Katsutani T, Tsuboi S, Ono K, Kawamoto S.

J Biol Chem. 2016 Oct 7;291(41):21607-21615. Epub 2016 Aug 18.

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