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Items: 1 to 20 of 28


Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN.

J Biol Chem. 2017 Oct 27;292(43):17598-17608. doi: 10.1074/jbc.M117.804328. Epub 2017 Aug 31.


Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation.

Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN.

Cell Rep. 2016 Apr 19;15(3):460-470. doi: 10.1016/j.celrep.2016.03.036. Epub 2016 Apr 7.


PI3-kinase mutation linked to insulin and growth factor resistance in vivo.

Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR.

J Clin Invest. 2016 Apr 1;126(4):1401-12. doi: 10.1172/JCI84005. Epub 2016 Mar 14.


Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.

Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK.

Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7.


Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.

Dhawan S, Dirice E, Kulkarni RN, Bhushan A.

Diabetes. 2016 May;65(5):1208-18. doi: 10.2337/db15-1331. Epub 2016 Mar 2.


Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.

Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN.

Stem Cell Reports. 2016 Mar 8;6(3):357-67. doi: 10.1016/j.stemcr.2016.01.007. Epub 2016 Feb 11.


Harnessing immune cells to enhance β-cell mass in type 1 diabetes.

Dirice E, Kulkarni RN.

J Investig Med. 2016 Jan;64(1):14-20. doi: 10.1136/jim-d-15-00196.


SerpinB1 Promotes Pancreatic β Cell Proliferation.

El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN.

Cell Metab. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015 Dec 15.


Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.

Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN.

Cell Metab. 2015 Aug 4;22(2):239-52. doi: 10.1016/j.cmet.2015.07.015.


Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.

El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG 2nd, Smith RD, Qian WJ, Kulkarni RN.

J Proteome Res. 2015 Aug 7;14(8):3111-3122. doi: 10.1021/acs.jproteome.5b00587. Epub 2015 Jul 30.


Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions.

Kahraman S, Aydin C, Elpek GO, Dirice E, Sanlioglu AD.

J Diabetes Res. 2015;2015:450128. doi: 10.1155/2015/450128. Epub 2015 Jan 28.


Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.

Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E906-18. doi: 10.1152/ajpendo.00210.2014. Epub 2014 Sep 23.


Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum.

Teo AK, Valdez IA, Dirice E, Kulkarni RN.

Stem Cell Reports. 2014 Jun 12;3(1):5-14. doi: 10.1016/j.stemcr.2014.05.007. eCollection 2014 Jul 8.


p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.

Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7. doi: 10.1073/pnas.1322564111. Epub 2014 Jan 6.


Soluble factors secreted by T cells promote β-cell proliferation.

Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN.

Diabetes. 2014 Jan;63(1):188-202. doi: 10.2337/db13-0204. Epub 2013 Oct 2.


Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.

El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN.

Cell Rep. 2013 Feb 21;3(2):401-10. doi: 10.1016/j.celrep.2013.01.007. Epub 2013 Jan 31. Erratum in: Cell Rep. 2013 Mar 28;3(3):969.


Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young.

Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN.

J Biol Chem. 2013 Feb 22;288(8):5353-6. doi: 10.1074/jbc.C112.428979. Epub 2013 Jan 10.


TRAIL and DcR1 expressions are differentially regulated in the pancreatic islets of STZ- versus CY-applied NOD mice.

Dirice E, Kahraman S, Elpek GO, Aydin C, Balci MK, Omer A, Sanlioglu S, Sanlioglu AD.

Exp Diabetes Res. 2011;2011:625813. doi: 10.1155/2011/625813. Epub 2011 Nov 28.


Tracing of islet graft survival by way of in vivo fluorescence imaging.

Kahraman S, Dirice E, Hapil FZ, Ertosun MG, Ozturk S, Griffith TS, Sanlioglu S, Sanlioglu AD.

Diabetes Metab Res Rev. 2011 Sep;27(6):575-83. doi: 10.1002/dmrr.1216.


In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms.

Kahraman S, Dirice E, Sanlioglu AD, Yoldas B, Bagci H, Erkilic M, Griffith TS, Sanlioglu S.

Mol Imaging Biol. 2010 Jun;12(3):278-85. doi: 10.1007/s11307-009-0260-x. Epub 2009 Sep 30.


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