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Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases.

Saghafi T, Taheri RA, Parkkila S, Emameh RZ.

Int J Mol Sci. 2019 Jun 15;20(12). pii: E2939. doi: 10.3390/ijms20122939. Review.


Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.

Yu J, Feng Y, Wang Y, An R.

Arch Biochem Biophys. 2018 Sep 15;654:47-54. doi: 10.1016/ Epub 2018 Jul 18.


Dual role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells.

Katoch A, Suklabaidya S, Chakraborty S, Nayak D, Rasool RU, Sharma D, Mukherjee D, Faheem MM, Kumar A, Sharma PR, Senapati S, Kumar LD, Goswami A.

Mol Carcinog. 2018 Sep;57(9):1102-1115. doi: 10.1002/mc.22828. Epub 2018 May 15.


Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model.

Draz H, Goldberg AA, Tomlinson Guns ES, Fazli L, Safe S, Sanderson JT.

Invest New Drugs. 2018 Aug;36(4):718-725. doi: 10.1007/s10637-018-0595-8. Epub 2018 Apr 2.


Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT.

Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18.


Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor.

Popolo A, Pinto A, Daglia M, Nabavi SF, Farooqi AA, Rastrelli L.

Semin Cancer Biol. 2017 Oct;46:132-137. doi: 10.1016/j.semcancer.2017.06.002. Epub 2017 Jun 13. Review.


The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.

Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E.

J Nutr Biochem. 2017 Sep;47:113-119. doi: 10.1016/j.jnutbio.2017.05.005. Epub 2017 May 25.


Regulation of PCGEM1 by p54/nrb in prostate cancer.

Ho TT, Huang J, Zhou N, Zhang Z, Koirala P, Zhou X, Wu F, Ding X, Mo YY.

Sci Rep. 2016 Sep 29;6:34529. doi: 10.1038/srep34529.


2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice.

Moore RW, Fritz WA, Schneider AJ, Lin TM, Branam AM, Safe S, Peterson RE.

Toxicol Appl Pharmacol. 2016 Aug 15;305:242-249. doi: 10.1016/j.taap.2016.04.018. Epub 2016 May 3.


Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients.

Hwang C, Sethi S, Heilbrun LK, Gupta NS, Chitale DA, Sakr WA, Menon M, Peabody JO, Smith DW, Sarkar FH, Heath EI.

Am J Transl Res. 2016 Jan 15;8(1):166-76. eCollection 2016.


First results of the double-blind randomized placebo-controlled multicenter clinical trial of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN).

Paltsev M, Kiselev V, Drukh V, Muyzhnek E, Kuznetsov I, Andrianova E, Baranovskiy P.

EPMA J. 2016 Apr 2;7:5. doi: 10.1186/s13167-016-0057-3. eCollection 2016.


Role of BioResponse 3,3'-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience.

Li Y, Sarkar FH.

Med Princ Pract. 2016;25 Suppl 2:11-7. doi: 10.1159/000439307. Epub 2015 Oct 27. Review.


Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.

Gee JR, Saltzstein DR, Messing E, Kim K, Kolesar J, Huang W, Havighurst TC, Harris L, Wollmer BW, Jarrard D, House M, Parnes H, Bailey HH.

Eur J Cancer Prev. 2016 Jul;25(4):312-20. doi: 10.1097/CEJ.0000000000000189.


A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78).

Nayak D, Amin H, Rah B, Ur Rasool R, Sharma D, Gupta AP, Kushwaha M, Mukherjee D, Goswami A.

Chem Biol Interact. 2015 May 5;232:58-67. doi: 10.1016/j.cbi.2015.03.008. Epub 2015 Mar 17.


Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia.

Zhang WW, Feng Z, Narod SA.

J Biomed Res. 2014 Sep;28(5):339-48. doi: 10.7555/JBR.28.20140008. Epub 2014 Apr 20.

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