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A Combination Treatment Strategy for Hemorrhagic Shock in a Rat Model Modulates Autophagy.

Chu X, Schwartz R, Diamond MP, Raju RP.

Front Med (Lausanne). 2019 Dec 17;6:281. doi: 10.3389/fmed.2019.00281. eCollection 2019.


Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.

Tataranni T, Piccoli C.

Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Review.


Correlation of molecular and morphologic effects of thermoembolization in a swine model using mass spectrometry imaging.

Guo C, Baluya DL, Thompson EA, Whitley EM, Cressman ENK.

J Mass Spectrom. 2019 Dec 5. doi: 10.1002/jms.4477. [Epub ahead of print]


Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.

Abdel-Wahab AF, Mahmoud W, Al-Harizy RM.

Pharmacol Res. 2019 Dec;150:104511. doi: 10.1016/j.phrs.2019.104511. Epub 2019 Oct 31. Review.


GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.

Tian DD, Bennett SK, Coupland LA, Forwood K, Lwin Y, Pooryousef N, Tea I, Truong TT, Neeman T, Crispin P, D'Rozario J, Blackburn AC.

Pharmacol Res Perspect. 2019 Oct 8;7(6):e00526. doi: 10.1002/prp2.526. eCollection 2019 Dec.


An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis.

Novohradsky V, Markova L, Kostrhunova H, Trávníček Z, Brabec V, Kasparkova J.

Sci Rep. 2019 Sep 16;9(1):13327. doi: 10.1038/s41598-019-49774-x.


Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy.

Wei G, Sun J, Luan W, Hou Z, Wang S, Cui S, Cheng M, Liu Y.

J Med Chem. 2019 Oct 10;62(19):8760-8772. doi: 10.1021/acs.jmedchem.9b00644. Epub 2019 Sep 27.


The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo.

Stakišaitis D, Juknevičienė M, Damanskienė E, Valančiūtė A, Balnytė I, Alonso MM.

Cancers (Basel). 2019 Aug 20;11(8). pii: E1210. doi: 10.3390/cancers11081210. Review.


Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms.

Albatany M, Ostapchenko VG, Meakin S, Bartha R.

J Neurooncol. 2019 Sep;144(3):453-462. doi: 10.1007/s11060-019-03251-7. Epub 2019 Aug 7.


Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo.

Twarock S, Reichert C, Bach K, Reiners O, Kretschmer I, Gorski DJ, Gorges K, Grandoch M, Fischer JW.

Br J Pharmacol. 2019 Dec;176(23):4474-4490. doi: 10.1111/bph.14808. Epub 2019 Dec 9.


Metformin enhances antitumor action of sodium dichloroacetate against glioma C6.

Kolesnik DL, Pyaskovskaya ON, Yurchenko OV, Solyanik GI.

Exp Oncol. 2019 Jun;41(2):123-129. doi: 10.32471/exp-oncology.2312-8852.vol-41-no-2.13064.


Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.

Ohba T, Domoto S, Tanaka M, Nakamura S, Shimazawa M, Hara H.

Biol Pharm Bull. 2019;42(7):1140-1145. doi: 10.1248/bpb.b19-00009.


Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines.

Tataranni T, Agriesti F, Pacelli C, Ruggieri V, Laurenzana I, Mazzoccoli C, Sala GD, Panebianco C, Pazienza V, Capitanio N, Piccoli C.

Cells. 2019 May 18;8(5). pii: E478. doi: 10.3390/cells8050478.


MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy.

Cardoso AMS, Sousa M, Morais CM, Oancea-Castillo LR, Régnier-Vigouroux A, Rebelo O, Tão H, Barbosa M, Pedroso MCL, Jurado AS.

Hum Mol Genet. 2019 Aug 15;28(16):2738-2751. doi: 10.1093/hmg/ddz099.


Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression.

Jin S, Guo Y, Song D, Zhu Z, Zhang Z, Sun Y, Yang T, Guo Z, Wang X.

Inorg Chem. 2019 May 6;58(9):6507-6516. doi: 10.1021/acs.inorgchem.9b00708. Epub 2019 Apr 23.


Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment.

Korga A, Ostrowska M, Iwan M, Herbet M, Dudka J.

FEBS Open Bio. 2019 May;9(5):959-972. doi: 10.1002/2211-5463.12628. Epub 2019 Apr 11.


Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure.

Sheeran FL, Angerosa J, Liaw NY, Cheung MM, Pepe S.

Oxid Med Cell Longev. 2019 Feb 7;2019:4532592. doi: 10.1155/2019/4532592. eCollection 2019.


Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.

Fekir K, Dubois-Pot-Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, Morel F, Fromenty B, Musso O, Cabillic F, Corlu A.

Cancer Res. 2019 Apr 15;79(8):1869-1883. doi: 10.1158/0008-5472.CAN-18-2110. Epub 2019 Mar 5.


Effect of sodium dichloroacetate on apoptotic gene expression in human leukemia cell lines.

Abramek J, Bogucki J, Ziaja-Sołtys M, Stępniewski A, Bogucka-Kocka A.

Pharmacol Rep. 2019 Apr;71(2):248-256. doi: 10.1016/j.pharep.2018.12.003. Epub 2018 Dec 12.


Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.

El Sayed SM, Baghdadi H, Ahmed NS, Almaramhy HH, Mahmoud AA, El-Sawy SA, Ayat M, Elshazley M, Abdel-Aziz W, Abdel-Latif HM, Ibrahim W, Aboonq MS.

Med Hypotheses. 2019 Jan;122:206-209. doi: 10.1016/j.mehy.2018.11.012. Epub 2018 Nov 22.


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