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Items: 1 to 20 of 1254

1.

Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer.

Deng X, Wang Q, Cheng M, Chen Y, Yan X, Guo R, Sun L, Li Y, Liu Y.

J Cancer. 2020 Jan 1;11(4):962-973. doi: 10.7150/jca.34330. eCollection 2020.

2.

Biocompatible, crystalline and amorphous bismuth-based metal-organic frameworks for drug delivery.

Orellana-Tavra C, Köppen M, Li A, Stock N, Fairen-Jimenez D.

ACS Appl Mater Interfaces. 2020 Jan 15. doi: 10.1021/acsami.9b21692. [Epub ahead of print]

PMID:
31940165
3.

LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.

Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Päivinen P, Domènech-Moreno E, Andersson S, Wong IPL, Clevers H, Katajisto P, Mäkelä TP.

Gastroenterology. 2020 Jan 10. pii: S0016-5085(20)30072-X. doi: 10.1053/j.gastro.2019.12.033. [Epub ahead of print]

PMID:
31930988
4.

A Combination Treatment Strategy for Hemorrhagic Shock in a Rat Model Modulates Autophagy.

Chu X, Schwartz R, Diamond MP, Raju RP.

Front Med (Lausanne). 2019 Dec 17;6:281. doi: 10.3389/fmed.2019.00281. eCollection 2019.

5.

MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.

Liang Y, Zhu D, Hou L, Wang Y, Huang X, Zhou C, Zhu L, Wang Y, Li L, Gu Y, Luo M, Wang J, Meng X.

Br J Cancer. 2020 Jan 10. doi: 10.1038/s41416-019-0703-3. [Epub ahead of print]

PMID:
31919406
6.

Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.

Zhu X, Long D, Zabalawi M, Ingram B, Yoza BK, Stacpoole PW, McCall CE.

J Leukoc Biol. 2020 Jan 2. doi: 10.1002/JLB.3A1119-236R. [Epub ahead of print]

PMID:
31894617
7.

Gene Copy Number and Post-Transductional Mechanisms Regulate TRAP1 Expression in Human Colorectal Carcinomas.

Pietrafesa M, Maddalena F, Possidente L, Condelli V, Zoppoli P, Li Bergolis V, Rodriquenz MG, Aieta M, Vita G, Esposito F, Landriscina M.

Int J Mol Sci. 2019 Dec 24;21(1). pii: E145. doi: 10.3390/ijms21010145.

8.

Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.

Tataranni T, Piccoli C.

Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Review.

9.

Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma.

Meng G, Li B, Chen A, Zheng M, Xu T, Zhang H, Dong J, Wu J, Yu D, Wei J.

Br J Cancer. 2020 Jan;122(1):111-120. doi: 10.1038/s41416-019-0639-7. Epub 2019 Dec 10.

PMID:
31819179
10.

Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate.

Schoonjans CA, Joudiou N, Brusa D, Corbet C, Feron O, Gallez B.

Cancer Lett. 2020 Feb 1;470:18-28. doi: 10.1016/j.canlet.2019.12.003. Epub 2019 Dec 5.

PMID:
31812695
11.

Correlation of molecular and morphologic effects of thermoembolization in a swine model using mass spectrometry imaging.

Guo C, Baluya DL, Thompson EA, Whitley EM, Cressman ENK.

J Mass Spectrom. 2019 Dec 5. doi: 10.1002/jms.4477. [Epub ahead of print]

PMID:
31804009
12.

Repurposing dichloroacetate for the treatment of women with endometriosis.

Horne AW, Ahmad SF, Carter R, Simitsidellis I, Greaves E, Hogg C, Morton NM, Saunders PTK.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25389-25391. doi: 10.1073/pnas.1916144116. Epub 2019 Dec 2.

13.

Metabolic requirements of Besnoitia besnoiti tachyzoite-triggered NETosis.

Zhou E, Conejeros I, Gärtner U, Mazurek S, Hermosilla C, Taubert A.

Parasitol Res. 2019 Nov 28. doi: 10.1007/s00436-019-06543-z. [Epub ahead of print]

PMID:
31782011
14.

Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate.

Filimonova MV, Podosinnikova TS, Samsonova AS, Makarchuk VM, Shevchenko LI, Filimonov AS.

Bull Exp Biol Med. 2019 Nov;168(1):92-94. doi: 10.1007/s10517-019-04655-1. Epub 2019 Nov 25.

PMID:
31768777
15.

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway.

Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X.

J Cancer. 2019 Oct 15;10(24):6037-6047. doi: 10.7150/jca.34650. eCollection 2019.

16.

Drug-Induced Demyelinating Neuropathies.

Niimi N, Takaku S, Yako H, Sango K.

Adv Exp Med Biol. 2019;1190:357-369. doi: 10.1007/978-981-32-9636-7_23. Review.

PMID:
31760656
17.

HNF4 Regulates Fatty Acid Oxidation and is Required for Renewal of Intestinal Stem Cells in Mice.

Chen L, Vasoya RP, Toke NH, Parthasarathy A, Luo S, Chiles E, Flores J, Gao N, Bonder EM, Su X, Verzi MP.

Gastroenterology. 2019 Nov 21. pii: S0016-5085(19)41587-4. doi: 10.1053/j.gastro.2019.11.031. [Epub ahead of print]

PMID:
31759926
18.

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.

Abdel-Wahab AF, Mahmoud W, Al-Harizy RM.

Pharmacol Res. 2019 Dec;150:104511. doi: 10.1016/j.phrs.2019.104511. Epub 2019 Oct 31. Review.

PMID:
31678210
19.

News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments.

Comhaire F, Deslypere JP.

Med Hypotheses. 2020 Jan;134:109444. doi: 10.1016/j.mehy.2019.109444. Epub 2019 Oct 22.

20.

Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.

Wang JJ, Siu MK, Jiang YX, Leung TH, Chan DW, Cheng RR, Cheung AN, Ngan HY, Chan KK.

Oncoimmunology. 2019 Sep 5;8(11):e1659092. doi: 10.1080/2162402X.2019.1659092. eCollection 2019.

PMID:
31646108

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