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Items: 1 to 20 of 90


Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome.

Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E.

Neurobiol Dis. 2020 Jan 24;137:104772. doi: 10.1016/j.nbd.2020.104772. [Epub ahead of print]


Functional analysis of candidate genes from genome-wide association studies of hearing.

Ingham NJ, Rook V, Di Domenico F, James E, Lewis MA, Girotto G, Buniello A, Steel KP.

Hear Res. 2020 Mar 1;387:107879. doi: 10.1016/j.heares.2019.107879. Epub 2020 Jan 2.


Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression.

Tramutola A, Falcucci S, Brocco U, Triani F, Lanzillotta C, Donati M, Panetta C, Luzi F, Iavarone F, Vincenzoni F, Castagnola M, Perluigi M, Di Domenico F, Marco F.

Cancers (Basel). 2020 Jan 1;12(1). pii: E110. doi: 10.3390/cancers12010110.


Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses.

Di Domenico F, Zuliani I, Tramutola A.

Expert Rev Proteomics. 2019 Nov - Dec;16(11-12):951-964. doi: 10.1080/14789450.2019.1691919. Epub 2019 Nov 14.


Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives.

Lanzillotta C, Di Domenico F, Perluigi M, Butterfield DA.

CNS Drugs. 2019 Oct;33(10):957-969. doi: 10.1007/s40263-019-00658-8.


Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome.

Di Domenico F, Tramutola A, Barone E, Lanzillotta C, Defever O, Arena A, Zuliani I, Foppoli C, Iavarone F, Vincenzoni F, Castagnola M, Butterfield DA, Perluigi M.

Redox Biol. 2019 May;23:101162. doi: 10.1016/j.redox.2019.101162. Epub 2019 Mar 9.


Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.

Cimini FA, Arena A, Barchetta I, Tramutola A, Ceccarelli V, Lanzillotta C, Fontana M, Bertoccini L, Leonetti F, Capoccia D, Silecchia G, Di Cristofano C, Chiappetta C, Di Domenico F, Baroni MG, Perluigi M, Cavallo MG, Barone E.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1490-1501. doi: 10.1016/j.bbadis.2019.02.021. Epub 2019 Feb 28.


Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.

Sharma N, Tramutola A, Lanzillotta C, Arena A, Blarzino C, Cassano T, Butterfield DA, Di Domenico F, Perluigi M, Barone E.

Neurobiol Dis. 2019 May;125:176-189. doi: 10.1016/j.nbd.2019.02.003. Epub 2019 Feb 6.


Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome.

Tramutola A, Lanzillotta C, Barone E, Arena A, Zuliani I, Mosca L, Blarzino C, Butterfield DA, Perluigi M, Di Domenico F.

Transl Neurodegener. 2018 Nov 6;7:28. doi: 10.1186/s40035-018-0133-9. eCollection 2018.


Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies.

Di Domenico F, Lanzillotta C, Tramutola A.

Expert Rev Neurother. 2019 Jan;19(1):1-3. doi: 10.1080/14737175.2019.1540932. Epub 2018 Oct 30. No abstract available.


Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection.

Tramutola A, Abate G, Lanzillotta C, Triani F, Barone E, Iavarone F, Vincenzoni F, Castagnola M, Marziano M, Memo M, Garrafa E, Butterfield DA, Perluigi M, Di Domenico F, Uberti D.

Free Radic Biol Med. 2018 Dec;129:430-439. doi: 10.1016/j.freeradbiomed.2018.10.414. Epub 2018 Oct 12.


Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.

Barone E, Tramutola A, Triani F, Calcagnini S, Di Domenico F, Ripoli C, Gaetani S, Grassi C, Butterfield DA, Cassano T, Perluigi M.

Mol Neurobiol. 2019 Apr;56(4):2922-2943. doi: 10.1007/s12035-018-1231-5. Epub 2018 Aug 2.


Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.

Tramutola A, Sharma N, Barone E, Lanzillotta C, Castellani A, Iavarone F, Vincenzoni F, Castagnola M, Butterfield DA, Gaetani S, Cassano T, Perluigi M, Di Domenico F.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3309-3321. doi: 10.1016/j.bbadis.2018.07.017. Epub 2018 Jul 18.


Poly-ubiquitin profile in Alzheimer disease brain.

Tramutola A, Triani F, Di Domenico F, Barone E, Cai J, Klein JB, Perluigi M, Butterfield DA.

Neurobiol Dis. 2018 Oct;118:129-141. doi: 10.1016/j.nbd.2018.07.006. Epub 2018 Jul 9.


Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.

Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3181-3194. doi: 10.1016/j.bbadis.2018.07.005. Epub 2018 Jul 5.


Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.

Lanzillotta C, Tramutola A, Meier S, Schmitt F, Barone E, Perluigi M, Di Domenico F, Abisambra JF.

J Alzheimers Dis. 2018;62(1):347-359. doi: 10.3233/JAD-170617.


mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia.

Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA.

Free Radic Biol Med. 2018 Jan;114:94-101. doi: 10.1016/j.freeradbiomed.2017.08.009. Epub 2017 Aug 12. Review.


Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.

Fontaine SN, Ingram A, Cloyd RA, Meier SE, Miller E, Lyons D, Nation GK, Mechas E, Weiss B, Lanzillotta C, Di Domenico F, Schmitt F, Powell DK, Vandsburger M, Abisambra JF.

Neurobiol Aging. 2017 Aug;56:78-86. doi: 10.1016/j.neurobiolaging.2017.04.007. Epub 2017 Apr 18.


CURRENT DEVELOPMENTS IN DRUG ELUTING DEVICES: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis.

Spadaccio C, Nappi F, Al-Attar N, Coccia R, Perluigi M, Di Domenico F.

Drug Target Insights. 2017 Jan 3;10(Suppl 1):15-19. doi: 10.4137/DTI.S41240. eCollection 2016. No abstract available.


Cathepsin D as a therapeutic target in Alzheimer's disease.

Di Domenico F, Tramutola A, Perluigi M.

Expert Opin Ther Targets. 2016 Dec;20(12):1393-1395. Epub 2016 Nov 2. No abstract available.


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